Background: Frailty is strongly associated with adverse health
outcomes in older heart failure patients. Aims: We aimed to
explore the effect of frailty on unplanned readmissions and death in
chronic heart failure (CHF) patients aged 18 years or older.
Methods: 342 chronic heart failure patients aged 18 years or
older from heart centers of two tertiary care hospitals, located in
north-west of China, were enrolled between July and December 2020.
Frailty was assessed by the Tilburg Frailty Indicator. Patients were
followed for unplanned readmissions, all-cause mortality at 30, 60, and
90 days after discharge. Multivariate cox regression models were used to
analyze the effect of frailty on 90-day unplanned readmission and death
in patients with CHF. Results: Frailty prevalence was 54.7%
among 342 CHF patients, with a mean age of 64.65 ± 11.90 years. Compared
to non-frailty CHF patients, the frailty CHF patients were older and had
higher systolic blood pressure, longer duration of heart failure, more
severe cognitive function, and more comorbidities (
P<0.05). Patients in the frail group had a higher
incidence of unplanned readmission (73.1% vs. 26.9%, χ2
= 18.87, P < 0.01) and death (100% vs. 0%,
χ2 = 6.94, P < 0.01) than those in the non-frail
group. Multivariate cox regression analysis showed that frailty was an
independent risk factor for 90-day unplanned readmission (HR = 1.469,
95% CI 1.318-1.637, P < 0.01) and 90-day death
(HR=2.270, 95% CI 1.091-4.726, P<0.01) in patients
with CHF. Discussion: Evaluation of frailty among CHF patients,
include frailty in the routine evaluation of admission seems necessary
to provide personalized intervention to improving their prognosis.
Conclusion: Frailty is an independent predictor of unplanned
readmission and death 90-day after discharge in CHF patients aged 18
years or older.