Energy-based analysis of milling α-lactose monohydrate

Chen, Y.; Ding, Yulong; Papadopoulos, Dimitris; Ghadiri, Mojtaba

doi:10.1002/jps.10568

Cited by 16 publications

(7 citation statements)

References 15 publications

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“…In this study, only one speed setting (FAST) was implemented, and thus it was most likely that the breakage in particles to a smaller size occurred predominantly during the impaction of the stainless steel ball bearing with the particles, leading to fracture, crushing, and attrition (21). For example, the particles interacted with each other, as well as the ball bearing and the sides of the chamber, resulting in particle breakage and the production of smaller particles, when the ball bearing was in the impact mode (31). This has been shown to occur when the stresses generated on the particles exceed the elastic limit causing permanent deformation and/or fracture leading to particle breakage (31).…”

Section: Cryo-micro-ball Millmentioning

confidence: 99%

“…For example, the particles interacted with each other, as well as the ball bearing and the sides of the chamber, resulting in particle breakage and the production of smaller particles, when the ball bearing was in the impact mode (31). This has been shown to occur when the stresses generated on the particles exceed the elastic limit causing permanent deformation and/or fracture leading to particle breakage (31). The stresses occur from the resulting compression, shear and impaction with particles and surfaceparticle interactions.…”

Section: Cryo-micro-ball Millmentioning

confidence: 99%

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Micronization of a Soft Material: Air-Jet and Micro-Ball Milling

Saleem

Smyth

2010

AAPS PharmSciTech

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Abstract. The air-jet and ball-mill are frequently used in fine micronization of active pharmaceutical ingredients to the order of 1-5 μm, which is important for increasing dissolution rates, and also for pulmonary delivery. In this study, we investigated the ability of air-jet and ball-mill to achieve adequate micronization on the lab scale using a model soft material, Pluronic® F-68. Material mechanical properties were characterized using the nanometer 600. Pluronic® F-68 was ball-milled in a micro-mill at different material weights and durations in liquid nitrogen vapor. In comparison, a lab scale air-jet mill was used at various milling parameters according to a full factorial design, where the response factors were particle yield and particle size distribution, which was analyzed using laser diffraction and scanning electron microscopy. The yield achieved with the micro-ball mill was 100% but was~80% for the air-jet mill, which reduced the size of Pluronic® F-68 from 70 μm to sizes ranging between 23-39 μm median diameters. Ball milling produced particles less than 10 μm after 15 min. Although air-jet milling proved capable of particle size reduction of the relatively soft material Pluronic® F-68, limitations to the lower size range achievable were observed. The feed rate of the material into the air jet mill was a significant factor and slower feed rates lead to smaller sizes by allowing more time for particle collisions and subsequent particle breakage to occur. Micro-ball milling under cold condition was more successful at achieving a lower range particle size reduction of soft materials.

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Section: Cryo-micro-ball Millmentioning

confidence: 99%

Section: Cryo-micro-ball Millmentioning

confidence: 99%

Micronization of a Soft Material: Air-Jet and Micro-Ball Milling

Saleem

Smyth

2010

AAPS PharmSciTech

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“…characterized the energy-size relationship with the Rittinger's model for hammer milling wood chip and pellet. Among these studies, the Rittinger's model was recognized as the best approach to describe fine milling performance, as well as a good indicator for assessing a given comminution system [25][26][27]. However, predicting the energy consumption for micronized wood by mechanical milling with different operational conditions is still lacking.…”

Section: Introductionmentioning

confidence: 99%

Characterization of micronized wood and energy-size relationship in wood comminution

Jiang

Wang

Zhang

et al. 2017

Fuel Processing Technology

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Mechanical milling demonstrates potential in the pretreatment arena to valorize lignocellulosic biomass because it eliminates chemicals and simplifies processing. The development of physical properties and energy consumption for generating micronized particles are key factors affecting potential use. This study investigated the effect of input moisture content, and feedstock particle size on developing physical characteristics of micronized particles and the resultant specific energy consumption in the milling process. Wood particles with different sizes were effectively comminuted to less than 20-μm within several minutes using a vibratory ring and puck mill. Moisture content was found to be a key factor influencing the development of particle morphology and crystallinity. Lower moisture content resulted in much rounder particles with lower crystallinity, while higher moisture content resulted in the micronized particles with larger aspect ratio and crystallinity. Crystallinity index and median aspect ratio of the micronized particles were linearly correlated. The particle size change during milling was highly correlated to the specific energy consumption of milling through the Rittinger's model (0.91

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“…Such observations are in agreement with previous investigations. [23][24][25] In general, a decrease in median diameter from 115 AE 1 mm for the untreated lactose monohydrate to 63 AE 1 and 65 AE 1 mm for freshly milled and recrystallized lactose monohydrate samples was observed, respectively. It interesting to note however, that incremental increases in mill time resulted in an Figure 1.…”

Section: Results and Discussion Particle Sizing Of Processed Lactose mentioning

confidence: 89%