Energy and metabolic pathways in trefoil factor family member 2 (Tff2) KO mice beyond the protection from high-fat diet-induced obesity

Ghanemi, Abdelaziz; Melouane, Aicha; Mucunguzi, Octave; Yoshioka, Mayumi; St‐Amand, Jonny

doi:10.1016/j.lfs.2018.11.006

Cited by 16 publications

(17 citation statements)

References 55 publications

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“…TFF2 represents an important component and a stabilizer of the gastric mucus with the property of binding to the mucin MUC6 [9] and is also involved in tissue remodeling [2,10]. It is expressed in different species such as mouse [11], cow [12], rat [13], pork [9] and human [14]. In veterinary science, the animal models of TFF2-modified expression illustrate the importance of this protein in animal health as shown by studies investigating obesity, gastric secretion, asthma, etc [2,3,10,11].…”

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confidence: 99%

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Trefoil Factor Family Member 2 (TFF2) as an Inflammatory-Induced and Anti-Inflammatory Tissue Repair Factor

Ghanemi

Yoshioka

St‐Amand

2020

Animals

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confidence: 99%

“…Tff2 has been recently characterized as a high-fat diet-induced gene in the intestinal mucosa [41] and the knock out of this gene lead to a protection from high-fat diet-induced obesity [11,42]. Both these facts could be further considered for the future exploration of the links between inflammation and metabolics.…”

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confidence: 99%

Trefoil Factor Family Member 2 (TFF2) as an Inflammatory-Induced and Anti-Inflammatory Tissue Repair Factor

Ghanemi

Yoshioka

St‐Amand

2020

Animals

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“…Therefore, the key concept beyond identifying digestive mucosal diet-induced genes is to eventually identify new signals and responses to nutrient ingestion controlling food intake and energy expenditure. As an example of a potential signal molecule, the trefoil factor 2 ( Tff2 ) has been identified as a newly found HF-specific gene [ 106 ] for which its deficiency in mice leads to a protection from HF diet-induced obesity [ 111 , 112 ]. Among the hundreds of genes that are modulated after HF or LF meal ingestion [ 106 , 113 , 114 , 115 , 116 ], we put a spotlight on the Tff2 and its pathway as a potential targetable pathway for obesity molecular therapies.…”

Section: Diet-related Genes: a Focus On High-fat Diet To Identify mentioning

confidence: 99%

Exercise and High-Fat Diet in Obesity: Functional Genomics Perspectives of Two Energy Homeostasis Pillars

Ghanemi

Melouane

Yoshioka

et al. 2020

Genes

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The heavy impact of obesity on both the population general health and the economy makes clarifying the underlying mechanisms, identifying pharmacological targets, and developing efficient therapies for obesity of high importance. The main struggle facing obesity research is that the underlying mechanistic pathways are yet to be fully revealed. This limits both our understanding of pathogenesis and therapeutic progress toward treating the obesity epidemic. The current anti-obesity approaches are mainly a controlled diet and exercise which could have limitations. For instance, the “classical” anti-obesity approach of exercise might not be practical for patients suffering from disabilities that prevent them from routine exercise. Therefore, therapeutic alternatives are urgently required. Within this context, pharmacological agents could be relatively efficient in association to an adequate diet that remains the most efficient approach in such situation. Herein, we put a spotlight on potential therapeutic targets for obesity identified following differential genes expression-based studies aiming to find genes that are differentially expressed under diverse conditions depending on physical activity and diet (mainly high-fat), two key factors influencing obesity development and prognosis. Such functional genomics approaches contribute to elucidate the molecular mechanisms that both control obesity development and switch the genetic, biochemical, and metabolic pathways toward a specific energy balance phenotype. It is important to clarify that by “gene-related pathways”, we refer to genes, the corresponding proteins and their potential receptors, the enzymes and molecules within both the cells in the intercellular space, that are related to the activation, the regulation, or the inactivation of the gene or its corresponding protein or pathways. We believe that this emerging area of functional genomics-related exploration will not only lead to novel mechanisms but also new applications and implications along with a new generation of treatments for obesity and the related metabolic disorders especially with the modern advances in pharmacological drug targeting and functional genomics techniques.

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“…Some of the used approaches to generate obese animals in different studies are diet (mainly high-fat diet) [ 56 , 57 , 58 , 59 ], modified genes such as ob/ob [ 60 , 61 ] and db/db mice [ 62 , 63 ], and castration-induced obesity [ 64 , 65 ]. Even within the same method, variety can exist.…”

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Obese Animals as Models for Numerous Diseases: Advantages and Applications

2021

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With the advances in obesity research, a variety of animal models have been developed to investigate obesity pathogenesis, development, therapies and complications. Such obese animals would not only allow us to explore obesity but would also represent models to study diseases and conditions that develop with obesity or where obesity represents a risk factor. Indeed, obese subjects, as well as animal models of obesity, develop pathologies such as cardiovascular diseases, diabetes, inflammation and metabolic disorders. Therefore, obese animals would represent models for numerous diseases. Although those diseases can be induced in animals by chemicals or drugs without obesity development, having them developed as consequences of obesity has numerous advantages. These advantages include mimicking natural pathogenesis processes, using diversity in obesity models (diet, animal species) to study the related variabilities and exploring disease intensity and reversibility depending on obesity development and treatments. Importantly, therapeutic implications and pharmacological tests represent key advantages too. On the other hand, obesity prevalence is continuously increasing, and, therefore, the likelihood of having a patient suffering simultaneously from obesity and a particular disease is increasing. Thus, studying diverse diseases in obese animals (either induced naturally or developed) would allow researchers to build a library of data related to the patterns or specificities of obese patients within the context of pathologies. This may lead to a new branch of medicine specifically dedicated to the diseases and care of obese patients, similar to geriatric medicine, which focuses on the elderly population.

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Energy and metabolic pathways in trefoil factor family member 2 (Tff2) KO mice beyond the protection from high-fat diet-induced obesity

Cited by 16 publications

References 55 publications

Trefoil Factor Family Member 2 (TFF2) as an Inflammatory-Induced and Anti-Inflammatory Tissue Repair Factor

Trefoil Factor Family Member 2 (TFF2) as an Inflammatory-Induced and Anti-Inflammatory Tissue Repair Factor

Exercise and High-Fat Diet in Obesity: Functional Genomics Perspectives of Two Energy Homeostasis Pillars

Obese Animals as Models for Numerous Diseases: Advantages and Applications

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