Energising the E-factor: The E+-factor

Tieves, Florian; Tonin, Fabio; Fernández‐Fueyo, Elena; Robbins, John L.; Bommarius, Bettina; Bommarius, Andreas S.; Alcalde, Miguel; Hollmann, Frank

doi:10.1016/j.tet.2019.01.065

Cited by 71 publications

(75 citation statements)

References 49 publications

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“…The enzyme was produced via heterologous expression in Pichia pastoris following a previously reported procedure . The concentration of the enzyme was determined using CO difference spectra analysis as also described previously …”

Section: Methodsmentioning

confidence: 99%

“…[20] The concentration of the enzyme was determined using CO difference spectra analysis as also described previously. [20]…”

Section: Enzyme Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…However, the production of AaeUPO is still economically and environmentally challenging, therefore high enzymatic turnovers are necessary to create truly green processes. [20] This is particularly hampered by the instability of UPOs against their own co-substrate H 2 O 2 . [7,21] Many strategies are known for a H 2 O 2 supply in adequate concentrations, especially in situ generation by reduction of molecular oxygen is often applied e. g. via chemical, [22,23] enzymatic, [24][25][26][27][28][29] electrochemical [30][31][32][33][34][35][36] or photochemical [37][38][39][40][41][42][43][44][45] approaches to alleviate the instability issue, see Table S4 for a detailed comparison of the methods on the example of AaeUPO catalyzed hydroxylation of ethylbenzene.…”

Section: Introductionmentioning

confidence: 99%

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Photoenzymatic Hydroxylation of Ethylbenzene Catalyzed by Unspecific Peroxygenase: Origin of Enzyme Inactivation and the Impact of Light Intensity and Temperature

et al. 2019

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Photoenzymatic cascades can be used for selective oxygenation of C−H‐Bonds under mild conditions circumventing the hydrogen peroxide mediated peroxygenase inactivation via in situ H2O2 generation. Here, we report the “on demand” production of hydrogen peroxide via methanol assisted reduction of molecular oxygen using UV‐illuminated titanium dioxide (Aeroxide P25) combined with the enantioselective hydroxylation of ethylbenzene to (R)‐1‐phenylethanole catalyzed by the Unspecific Peroxygenase from Agrocybe Aegerita. For the application of the system it is important to understand the influence of the reaction parameters to be able to optimize the system. Therefore, we systematically investigated product formation and enzyme inactivation as well as ROS formation (H2O2, .OH and .O2−) applying different light intensities and temperatures. As a result, Turnover Numbers up to 220 000, photonic efficiencies up to 13.6 % and production rates up to 0.9 mM h−1 were achieved.

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Section: Methodsmentioning

confidence: 99%

“…[20] The concentration of the enzyme was determined using CO difference spectra analysis as also described previously. [20]…”

Section: Enzyme Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Photoenzymatic Hydroxylation of Ethylbenzene Catalyzed by Unspecific Peroxygenase: Origin of Enzyme Inactivation and the Impact of Light Intensity and Temperature

et al. 2019

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“…The atom economy is one of the rules of green chemistry. Although the actual meaning of the atom economy is idiomatic and applies more to chemistry than to the economy, the clear economy-based descriptors were inspired by this approach and were analyzed in the economic dimension, e.g., the E factor-or related E + factor-the proportion of the waste material to desired products [40]. The concept of circular chemistry that is integrated with a circular economy has recently been proposed.…”

Section: Environmental Catalysis Is Where Economy Drives Chemistrymentioning

confidence: 99%

Ru and Ni—Privileged Metal Combination for Environmental Nanocatalysis

et al. 2020

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Privileged structures is a term that is used in drug design to indicate a fragment that is popular in the population of drugs or drug candidates that are in the application or investigation phases, respectively. Privileged structures are popular motifs because they generate efficient drugs. Similarly, some elements appear to be more efficient and more popular in catalyst design and development. To indicate this fact, we use here a term privileged metal combination. In particular, Ru-based catalysts have paved a bumpy road in a variety of commercial applications from ammonia synthesis to carbon (di)oxide methanation. Here, we review Ru/Ni combinations in order to specifically find applications in environmental nanocatalysis and more specifically in carbon (di)oxide methanation. Synergy, ensemble and the ligand effect are theoretical foundations that are used to explain the advantages of multicomponent catalysis. The economic effect is another important issue in blending metal combinations. Low temperature and photocatalytic processes can be indicated as new tendencies in carbon (di)oxide methanation. However, due to economics, future industrial developments of this reaction are still questionable.

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Biokatalytische Reduktionen aus der Sicht eines Chemikers

Hollmann

Opperman²,

Paul

2020

Angewandte Chemie

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Reduktionsreaktionen spielen eine zentrale Rolle in der organischen Chemie zur Synthese chiraler Produkte. Insbesondere Enzyme katalysieren solche Reaktionen in hoher Stereo‐, Regio‐ und Chemoselektivität. Somit eröffnen sie kürzere Alternativrouten zur Synthese von Spezial‐ und Bulkchemikalien. Dieser Aufsatz beschreibt den aktuellen Stand, die Herausforderungen und Möglichkeiten enzymkatalysierter Reduktionen von (konjugierten) Carbonylverbindungen, Aromaten sowie der reduktiven Aminierung.

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Energising the E-factor: The E+-factor

Cited by 71 publications

References 49 publications

Photoenzymatic Hydroxylation of Ethylbenzene Catalyzed by Unspecific Peroxygenase: Origin of Enzyme Inactivation and the Impact of Light Intensity and Temperature

Photoenzymatic Hydroxylation of Ethylbenzene Catalyzed by Unspecific Peroxygenase: Origin of Enzyme Inactivation and the Impact of Light Intensity and Temperature

Ru and Ni—Privileged Metal Combination for Environmental Nanocatalysis

Biokatalytische Reduktionen aus der Sicht eines Chemikers

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