Endurance Training-Induced Increase in Circulating Irisin Levels Is Associated with Reduction of Abdominal Visceral Fat in Middle-Aged and Older Adults

Miyamoto‐Mikami, Eri; Sato, Koji; Kurihara, Toshiyuki; Hasegawa, Natsuki; Fujie, Shumpei; Fujita, Satoshi; Sanada, Kiyoshi; Hamaoka, Toshiyuki; Tabata, Izumi; Iemitsu, Motoyuki

doi:10.1371/journal.pone.0120354

Cited by 111 publications

(97 citation statements)

References 25 publications

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“…In fact, irisin is known as an exercise-induced myokine (17) and several studies have documented the relationship between FNDC5/irisin expression and intensity, duration and type of exercise (11,18,19). The expression that irisin is an exercise-induced myokine dependent on PGC-1ɑ is based on the research carried out by Boström et al (2012), who managed to demonstrate that the levels of FNDC5 mRNA in mice's skeletal muscle had an increase of about 2.8 times after 3 weeks of optional training on the treadmill.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

Rashidlamir

Hoseinzadeh

Dashtkhaki

2017

Ann. Appl. Sport Sci

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Background. The accumulation of excess triglyceride in the liver and a decrease in brown adipose tissue is related to the fatty liver disease. Regular physical activity can take part in regulating fat oxidation and inhibiting fat accumulation by creating and releasing some myokines. Nevertheless, the effectiveness of each training method in this regard is still not certain. Objective(s). This study aims at comparing the effects of resistance and endurance training on FNDC5 (the precursor of irisin myokine) gene expression in male rat liver tissues.. Methods. Fifteen Wistar male rats (aged 10-12 weeks with an average weight of 331.8 ±63.09 gr) were used. After being taken to the animals' laboratory, the subjects were randomly assigned to three equal groups viz: control (N=5), endurance (N=5) and resistance (N=5). For the purpose of tissue sampling, all these subjects were anesthetized 72 hours after the experiment had been completed. The liver tissue was immediately removed and then quickly frozen in liquid nitrogen and kept at a temperature of -80o C until RNA extraction. FNDC5 relative gene expression was identified by Real-time PCR method. Results. Data analysis revealed a significant difference in FNDC5 gene expression among the groups (P=0.008, Chi Square=31.791). No significant difference was observed between the resistance training and endurance training groups in FNDC5 gene expression, though (P=0.959). Conclusion. It can be established that both resistance and endurance training can similarly affect the production and secretion of exerciseinduced myokines, including FNDC5 irisin, which can in turn protect against obesity and its impacts on the liver tissue by stimulating the process of browning of white fat.

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Section: Introductionmentioning

confidence: 99%

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

Rashidlamir

Hoseinzadeh

Dashtkhaki

2017

Ann. Appl. Sport Sci

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“…We are unaware of any research pertaining to other dietary supplements that elevate BDNF levels over a two week period. Irisin levels, which were significantly increased in CLOCK® subjects, have been shown to increase in middle-aged, older individuals after 8 weeks of endurance training [40].…”

Section: Discussionmentioning

confidence: 95%

Impact of the Dietary Supplement CLOCK® on BDNF and Other Biochemical Measures Related to Cognitive Function and Health in Men and Women

Bloomer

2017

ACIM

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Background: We have previously reported improvements in selected biochemical measures of health, as well as self reported well-being in men and women using the dietary supplement known as CLOCK ® . In this follow up investigation, we evaluated CLOCK ® at two different dosages using a randomized, placebo controlled, cross-over design in men and women with self reported low energy, impaired sleep quality and impaired well-being.Methods: 30 subjects (14 men and 16 women) were randomly assigned in double blind manner to ingest a botanical agent (CLOCK ® , containing Rosmarinus officinalis and Hemerocallis fulva at either 1gram or 1.5grams daily) or a placebo for two week periods with a two week wash out period after each condition assignment. Blood samples were collected pre and post each two week period in an overnight fasted state and analyzed for acetylcholine (ACh), choline, Brain Derived Neurotrophic Factor (BDNF), IGF-1, irisin, melatonin and serotonin. Heart rate and blood pressure were measured, as were subjective measures of well-being. The Leeds Sleep Evaluation Questionnaire was used as a measure of sleep quality and related variables.Results: ACh (22%), choline (19%), BDNF (44%), irisin (23%) and melatonin (8%) all increased significantly from pre to post intervention following intake of CLOCK ® (with a greater increase noted with 1gram vs. 1.5grams) but not placebo. Heart rate and blood pressure were unaffected by treatment (p>0.05). Time effects were noted for all well-being measures (p<0.05), except for anxious, depressed and tense, with improvements noted in all variables from pre to post intervention. When considering both supplement dosages together, improvements of 25% (attentiveness), 21% (alertness), 37% (focus) and 34% (energetic) were observed, with slightly less improvement noted for placebo. Although, not significant, CLOCK ® reduced the feeling of grogginess (25%), lethargy (14%) and sluggishness (18%); whereas there were minimal changes with the placebo. No differences were noted between conditions or across time in measures of sleep or related variables (p>0.05).

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“…Осам студија (Dunstan et al, 2002;Fujita et al, 2003;Kodama, Shu, Saito, Murakami, Tanaka, Kuno, & Shimano et al, 2007;Coker et al, 2009;Chen, Godfrey, Ng, Moorthi, Liangos, Ruthazer, & Castaneda-Sceppa et al, 2010;Vroege, Wijsman, Broekhuizen, de Craen, van Heemst, van der Ouderaa, & Verhagen et al, 2014;Miyamoto-Mikami, Sato, Kurihara, Hasegawa, Fujie, Fujita, & Iemitsu et al, 2015;Wijsman et al, 2016) су обухватиле испитанике мушког и женског пола, пет студија (Cooper et al, 1998;Hansen, Dendale, Jonkers, Beelen, Manders, Corluy, & Van Loon et al, 2009;Kim & Kim 2013;Bruseghini, Calabria, Tam, Milanese, Oliboni, Pezzato, & Capelli et al, 2015;Andersen et al, 2016) 3 "body composition", "elderly people", "60-70 years", "effects", "aerobic training", "endurance training", "high intensity training" .…”

Section: дискусијаmentioning

confidence: 99%

“…Најчешће је програм тренинга трајао 12 недеља (пет студија) (Grant et al, 2004;Kim еt al., 2004;Kodama et al, 2007;Coker et al, 2009;Bakhtiari et al, 2012), затим 52 недеље (три студије) (Dunstan еt al., 2002;Kim & Kim 2013;Andersen et al, 2016), осам недеља (две студије) (Bruseghini et al, 2015;Miyamoto-Mikami et al, 2015), 14 недеља (две студије) (Kemmler еt al., 2010;Vroege et al, 2014), 26 недеља (две студије) (Hansen et al, 2009;Lee et al, 2013), шест недеља (једна студија) (Pilch et al ., 2016), 13 недеља (једна студија) (Wijsman et al, 2016), 24 недеље (једна студија) (Chen et al, 2010), 25 недеља (једна студија) (Fujita et al, 2003), 36 недеља (једна студија) (Park еt al., 2003), док је једна студија имала тренинг програм који је био заступљен 10 година (Cooper et al, 1998) .…”

Section: дискусијаunclassified

“…Тренинг издржљивости код млађих и старијих особа доводи до смањења телесне тежине, телесних масти, до повећања VO2max (Miyamoto-Mikami et al, 2015), а код старијих доводи до оксидације масти, долази до промена и у мишићним влакнима (Kim еt al., 2004). Студије које су релизивале 3-месечни интервациони програм физичке активности (DirectLife, Philips, Consumer Lifestyle, Amsterdam) указују да долази до смањења телесне тежине, обима струка, BMI (Vroege et al, 2014), а такође доводи до смањења телесних масти и нивоа инсулина (Wijsman et al, 2016).…”

Section: дискусијаunclassified

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Research on the impact of exercise on body composition of elderly

Nikola¹,

Andjelkovic²,

Licina³

2016

God Fak sporta fiz vaspit

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ОСОБА СажетакТелесни састав је компонента здравља која је уско повезана са вредностима мишића, масти, воде, кости, као и осталим виталним деловима човечијег тела. Предмет истраживања представљају студије публиковане у периоду од 1998 . до 2016. године, фокусиране на утицај програма вежбања на телесни састав старијих особа, узраста 58-70 година. Овај преглед је имао за циљ да идентификује и сумира телесни састав старијих особа, као и да појасни да ли постоји утицај програма вежбања на телесни састав старијих особа. Резултати ове студије потврђују бројне закључке претходних студија да вежбање представља битан фактор у редукцији телесног састава старијих особа. Урађени систематски преглед показује да у поређењу са пасивном контролном групом, група која вежба остварује значајне резултате у побољшању телесног састава старијих особа. Препорука је да аеробни тренинг, високо интензивни тренинг, тренинг издржљивости, тренинг са отпором, тренинг снаге, или комбинација наведених типова тренинга представљају сигуран начин за редукцију телесног састава старијих особа . Међутим, поједина неслагања свакако могу бити приписана карактеристикама узорка испитаника, а поред тога, добијени резултати могу варирати у зависности од трајања и врсте активности. Кључне речи: СТАРИЈЕ ОСОБЕ / ФИЗИЧКО ВЕЖБАЊЕ / ТЕЛЕСНА КОМПОЗИЦИЈА RESEARCH ON THE IMPACT OF EXERCISE ON BODY COMPOSITION OF ELDERLY SummaryBody composition is a component of health, which is closely linked with the values of muscle, fat, water, bone, and other vital parts of the human body . The subject of research are studies published in the period from 1998 to 2016, focused on the impact of the program of exercise on body composition in older people, aged 58-70 years . This review aimed to identify and summarize the body composition of the elderly, as well as to clarify whether there is an impact exercise program on body composition in the elderly . The results of this study confirm the conclusions of many previous studies that exercise is an important factor in the reduction of body composition of the elderly . Made a systematic review shows that compared with passive control group achieved significant results in improving body composition of elderly people . It is recommended that aerobic training, high-intensity training, endurance training, resistance training, strength training, or a combination of these types of training are a sure way to reduce the body composition of the elderly, however, individual differences can certainly be attributed to the characteristics of the sample, and in addition obtained results may vary depending on the duration and type of activity .

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Endurance Training-Induced Increase in Circulating Irisin Levels Is Associated with Reduction of Abdominal Visceral Fat in Middle-Aged and Older Adults

Cited by 111 publications

References 25 publications

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

Impact of the Dietary Supplement CLOCK® on BDNF and Other Biochemical Measures Related to Cognitive Function and Health in Men and Women

Research on the impact of exercise on body composition of elderly

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