Endurance running acutely raises plasma osteoprotegerin and lowers plasma receptor activator of nuclear factor κ B ligand

Ziegler, Sophie; Niessner, Alexander; Richter, Bernhard; Wirth, S.; Billensteiner, Elke; Woloszczuk, W.; Slaný, J; Geyer, G

doi:10.1016/j.metabol.2005.02.009

Cited by 29 publications

(27 citation statements)

References 20 publications

(23 reference statements)

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“…Increased OPG has been reported with running [17,19,31,58], but in the present study, OPG was increased before exercise and remained so into recovery, suggesting that OPG was not related to the different P-CTX responses. If RANKL were to increase, a greater relative increase in P-CTX could result.…”

Section: 6contrasting

confidence: 74%

Effect of fasting versus feeding on the bone metabolic response to running

Scott

Sale

Greeves³

et al. 2012

Bone

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Abbreviations: ACa, albumin-adjusted calcium; Bone ALP, bone alkaline phosphatase; BMD, bone mineral density; P-CTX, C-terminal telopeptide region of collagen type 1; CHO, carbohydrate; FAST, overnight fast from 21:00; FED, a standardised breakfast consumed at 08:15; GLP-1, glucagon-like peptide-1; GLP-2, glucagon-like peptide-2; GIP, glucosedependent insulinotropic polypeptide; LMM, linear mixed model; OC, osteocalcin; OPG, osteoprotegerin; P1NP, N-terminal propeptides of procollagen type 1; PTH, parathyroid hormone; PO4, phosphate; RER, respiratory exchange ratio; RPE, ratings of perceived exertion; VO2, oxygen uptake; V02max, maximal rate of oxygen uptake. ABSTRACTIndividuals often perform exercise in the fasted state, but the effects on bone metabolism are not currently known. We compared the effect of an overnight fast with feeding a mixed meal on the bone metabolic response to treadmill running. Ten, physically-active males aged 28 ± 4 y (mean ± 1SD) completed two, counterbalanced, 8 d trials. After 3 d on a standardised diet, participants performed 60 min of treadmill running at 65% V02max on Day 4 following an overnight fast (FAST) or a standardised breakfast (FED). Blood samples were collected at baseline, before and during exercise, for 3h after exercise, and on four consecutive follow-up days (FU1-FU4). Plasma/serum were analysed for the c-terminal telopeptide region of collagen type 1 (P-CTX), n-terminal propeptides of procollagen type 1 (P1NP), osteocalcin (OC), bone alkaline phosphatase (bone ALP), parathyroid hormone (PTH), albumin-adjusted calcium, phosphate, osteoprotegerin (OPG), Cortisol, leptin and ghrelin. Only the P-CTX response was significantly affected by feeding. Pre-exercise concentrations decreased more in FED compared with FAST (47% vs 26%, P < 0.001) but increased during exercise in both groups and were not significantly different from baseline at 1 h post-exercise. At 3 h post-exercise, concentrations were decreased (33%, P < 0.001) from baseline in FAST and significantly lower (P < 0.001) than in FED. P1NP and PTH increased, and OC decreased during exercise. Bone markers were not significantly different from baseline on FU1-FU4.Fasting had only a minor effect on the bone metabolic response to subsequent acute, endurance exercise, reducing the duration of the increase in P-CTX during early recovery, but having no effect on changes in bone formation markers. The reduced duration of the P-CTX response with fasting was not fully explained by changes in PTH, OPQ leptin or ghrelin.

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Section: 6contrasting

confidence: 74%

Effect of fasting versus feeding on the bone metabolic response to running

Scott

Sale

Greeves³

et al. 2012

Bone

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“…RANKL exists in two forms, a soluble form (sRANKL) and a membrane bound form thought to be responsible for initiating osteoclast formation (4,52). sRANKL is found in the circulatory system of both animals and human (35,46,53,61). It is thought to play a role in immune response and bone repair (27,34,39,46) and recently has been shown to decrease with endurance physical activity (61).…”

Section: Introductionmentioning

confidence: 99%

“…sRANKL is found in the circulatory system of both animals and human (35,46,53,61). It is thought to play a role in immune response and bone repair (27,34,39,46) and recently has been shown to decrease with endurance physical activity (61). A recent study by Hikita et al (11) indicated that soluble RANKL can be secreted by primary osteoblasts.…”

Section: Introductionmentioning

confidence: 99%

Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading

You

Temiyasathit

Lee

et al. 2008

Bone

290

156

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Bone has the ability to adjust its structure to meet its mechanical environment. The prevailing view of bone mechanobiology is that osteocytes are responsible for detecting and responding to mechanical loading and initiating the bone adaptation process. However, how osteocytes signal effector cells and initiate bone turnover is not well understood. Recent in vitro studies have shown that osteocytes support osteoclast formation and activation when co-cultured with osteoclast precursors. In this study, we examined the osteocytes' role in the mechanical regulation of osteoclast formation and activation.We demonstrated here that 1) Mechanical stimulation of MLO-Y4 osteocyte-like cells decreases their osteoclastogenic-support potential when co-cultured with RAW264.7 monocyte osteoclast precursors, 2) Soluble factors released by these mechanically stimulated MLO-Y4 cells inhibit osteoclastogenesis induced by ST2 bone marrow stromal cells or MLO-Y4 cells, and 3) Soluble RANKL and OPG were released by MLO-Y4 cells, and the expressions of both were found to be mechanically regulated.Our data suggests that mechanical loading decreases the osteocyte's potential to induce osteoclast formation by direct cell-cell contact. However, it is not clear that osteocytes in vivo are able to form contacts with osteoclast precursors. Our data also demonstrates that mechanically stimulated osteocytes release soluble factors that can inhibit osteoclastogenesis induced by other supporting

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“…By contrast, soluble RANK-L was negatively related with age (rS -0.48, p=0.018) and urinary Ca/creatinine ratio (rS -0.51, p=0.01). Other serum parameters were found in the normal range, but PTH was slightly increased in four patients (cases 4, 13, 14, 24), osteocalcin in four (cases 10, 11, 14, 15), phosphorus in one 21 and ALP in two, 7,12 while creatinine and ALP were slightly reduced in cases 12 called standard deviation scores, which indicate the deviation from normal values, were calculated by means of the following equations: T score = BMD measured -BMD young normal population/SD; Z score = BMD measured -BMD sex-and age-matched population/SD.…”

Section: Assaysmentioning

confidence: 89%

“…8 In a group of endurance runners, a significant decrease in RANK-L was observed during running, the extent of which seems to be correlated with the distance covered. 21 Moreover, reduced soluble RANK-L levels in DTC in comparison with healthy euthyroid age-matched controls have recently been reported. 19 Our knowledge of the OPG/RANK/RANK-L system in humans is still scant.…”

Section: Introductionmentioning

confidence: 97%

Recombinant human thyroid stimulating hormone does not acutely change serum osteoprotegerin and soluble receptor activator of nuclear factor-?? ligand in patients under evaluation for differentiated thyroid carcinoma*

Giusti

Cecoli

Ghiara

et al. 2007

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ObJEctIVE: some extra-thyroid actions of thyroid stimulating hormone (tsH), such as an in vitro action on bone, have been described. Our aim was to evaluate in vivo the acute effect of a recombinant human tsH (rhtsH)-induced tsH surge on Osteoprotegerin (OPG) and receptor activator of the nuclear factor-κb (rANK-L) levels in patients under levo-thyroxine (L-t4) therapy. DEsIGN: 24 patients with differentiated thyroid carcinoma (Dtc) were studied. standard rhtsH testing was performed. OPG, rANK-L, tsH, thyroid hormones, thyroglobulin and several parameters of bone metabolism were evaluated. rEsuLts: baseline OPG and rANK-L levels were in the range of our reference population. An inverse correlation between OPG and spinal Z-score (p=0.029) and between rANK-L and age (p=0.018) or urinary calcium/creatinine ratio (p=0.011) was detected. After rhtsH administration, a significant (p<0.001) increase in tsH was found. No significant increase in OPG or rANK-L levels after rhtsH was observed. No correlation was detected between tsH peak value after rhtsH and maximal percentage change in OPG or rANK-L. A slight increase in urinary cross-links after rhtsH was found. cONcLusIONs: In a small group of subjects with a history of Dtc on Lt4 regimen, our study did not support an acute direct effect of tsH on OPG and rANK-L.

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Endurance running acutely raises plasma osteoprotegerin and lowers plasma receptor activator of nuclear factor κ B ligand

Cited by 29 publications

References 20 publications

Effect of fasting versus feeding on the bone metabolic response to running

Effect of fasting versus feeding on the bone metabolic response to running

Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading

Recombinant human thyroid stimulating hormone does not acutely change serum osteoprotegerin and soluble receptor activator of nuclear factor-?? ligand in patients under evaluation for differentiated thyroid carcinoma*

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