Endurance Exercise Training reduces Blood Pressure according to the
                    Wilder’s Principle

Mora-Rodríguez, Ricardo; Ortega, Juan F.; Morales-Palomo, Félix; Ramírez-Jiménez, Miguel; Moreno‐Cabañas, Alfonso; Álvarez-Jimenez, Laura

doi:10.1055/a-1548-6985

Cited by 5 publications

(3 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After 16 weeks of HIIT, the EXER+MET group lowered MAP by 4 mm Hg whereas the EXER group lowered it by 8 mm Hg ( p = 0.02 for the interaction; Table 1). The higher initial blood pressure in the EXER group could have contributed to the larger blood pressure‐lowering effect of the same training program in this group (43). However, this comparative resistance to lower blood pressure with training in the EXER+MET group coincides with a previous report from Malin and Braun’s group (22).…”

Section: Discussionmentioning

confidence: 99%

Effects of chronic metformin treatment on training adaptations in men and women with hyperglycemia: A prospective study

Moreno‐Cabañas

Morales-Palomo

Álvarez-Jimenez

et al. 2022

Obesity

Self Cite

View full text Add to dashboard Cite

INTRODUC TI ONMetabolic syndrome (MetS) is characterized by central obesity, dyslipidemia, hypertension, and hyperglycemia (1), which increase cardiovascular disease risk and all-cause mortality (2). Some authors have supported insulin resistance (IR) as the triggering factor for MetS (3,4). IR by itself is a predictor of disease, disability, and all-cause mortality (5). On the other hand, longitudinal studies have shown that moderate and high levels of cardiorespiratory fitness ([CRF] assessed by maximal oxygen uptake [VO 2MAX ]) confer protection

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of chronic metformin treatment on training adaptations in men and women with hyperglycemia: A prospective study

Moreno‐Cabañas

Morales-Palomo

Álvarez-Jimenez

et al. 2022

Obesity

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, greater reductions of ABP seem to occur in patients with RH. These differences might be due to the so-called Wilder's principle ( 38 ) — that is, exercise induces larger effects in those patients with higher BP at baseline, such as those with the most severe hypertension phenotypes, notably RH. Other factors can also be involved in these differences, notably the lower number of studies included in the present meta-analysis, which could have partly confounded our results, along with the fact that in one study exercise was performed in a heated pool, which can magnify the hypotensive effects of exercise per se ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Physical Exercise in Resistant Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Saco-Ledo

Ruilope

Lucía

2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Physical exercise reduces blood pressure (BP) in patients with hypertension in general but more evidence is needed specifically for a high-risk phenotype associated with intensive medication, resistant hypertension (RH). In this systematic review and meta-analysis, we aimed to summarize current evidence of the exercise effects on BP in patients with RH. A systematic search was conducted in PubMed, Web of Science and Cochrane Library (from inception to 3rd November, 2021). A random effects meta-analysis was performed when at least two trials assessed the effect of either acute or regular exercise (vs. a control condition) on the same outcome. Ten studies (N = 380 participants; 51% female; mean age 52 to 67 years) were included in the review, of which four (N = 58) and six (N = 322) assessed the effects of acute and regular exercise, respectively. Evidence overall suggests that a single bout of acute exercise results in a short-term (≤ 24 h) reduction of BP, although no meta-analysis could be performed. As for regular exercise, three randomized controlled trials (N = 144, 50% female) could be meta-analyzed, which showed that exercise training intervention (8–12 weeks, 3 sessions/week) significantly reduces 24-h (−9.9 mmHg, 95% confidence interval −15.4−4.4 for systolic BP; and −5 mmHg, −7.0−3.0 for diastolic BP) and daytime ambulatory BP (−11.7 mmHg, −17.8−5.7; and −7.4 mmHg, −11.9−2.9). In summary, physical exercise appears as an effective option to reduce BP in patients with RH, although more research is needed to confirm these findings as well as to determine the most effective exercise characteristics.

show abstract

“…Some of the larger studies published recently are presented in Table 1 (Ref. [ 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 ]); Fig. 1 outlines key findings from the studies.…”

Section: Interventional Studiesmentioning

confidence: 99%

Physical Activity and Hypertension

Hayes¹,

Ferrara²,

Keating³

et al. 2022

Rev. Cardiovasc. Med.

View full text Add to dashboard Cite

Hypertension and physical inactivity are leading causes of premature mortality. While both are modifiable risk factors for cardiovascular disease, their prevalence remains high. As populations grow older, they are more likely to develop hypertension and to become less physically active. Scientific advances have contributed to understanding of how physical activity improves blood pressure and the clinically relevant ambulatory blood pressure, but this is not reflected in hypertension guidelines for clinical management of hypertension. The aim of this paper is to clearly present up to date knowledge from scientific studies that underpin the role of physical activity in hypertension management. Longitudinal studies in this review demonstrate a protective effect of higher physical activity levels as well as higher levels of cardiorespiratory fitness. Interventional studies report improvements in blood pressure associated with aerobic, resistance and concurrent exercise; the improvements in some studies were greatest among participant groups with established hypertensions; the effect was observed for groups with treatment-resistant hypertension also, a clinically important subgroup. The most recent research provides evidence for the synergy between physical activity and pharmacotherapy for the treatment of hypertension, providing an opportunity for clinicians to promote physical activity as an adjunctive treatment for hypertension as well as a preventative strategy. This review critiques the evidence and summarises the most up to date literature in the field of physical activity and hypertension.

show abstract

Endurance Exercise Training reduces Blood Pressure according to the Wilder’s Principle

Cited by 5 publications

References 40 publications

Effects of chronic metformin treatment on training adaptations in men and women with hyperglycemia: A prospective study

Effects of chronic metformin treatment on training adaptations in men and women with hyperglycemia: A prospective study

Physical Exercise in Resistant Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Physical Activity and Hypertension

Contact Info

Product

Resources

About