Endurance Exercise Mobilizes Developmentally Early Stem Cells into Peripheral Blood and Increases Their Number in Bone Marrow: Implications for Tissue Regeneration

Marycz, Krzysztof; Mierzejewska, Katarzyna; Śmieszek, Agnieszka; Suszyńska, Ewa; Malicka, Iwona; Kucia, Magda; Ratajczak, Mariusz Z.

doi:10.1155/2016/5756901

Cited by 53 publications

(62 citation statements)

References 33 publications

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“…As recently reported, the number of VSELs in murine BM increases in vivo in response to regular physical activity and prolonged caloric restriction 116,117 . On the other hand, highly quiescent VSELs in murine BM may enter the cell cycle, as confirmed by bromodeoxyuridine (BrdU) accumulation in these cells after administration of sex hormones (SexHs, such as follicle stimulating factor [FSH] or luteinizing hormone [LH]) or erythropoietin (EpO) 88,89 .…”

Section: The Discovery Of Very Small Embryonic-like Stem Cells (Vselsmentioning

confidence: 55%

A Novel View of the Adult Stem Cell Compartment From the Perspective of a Quiescent Population of Very Small Embryonic-Like Stem Cells

et al. 2017

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Evidence has accumulated that adult hematopoietic tissues and other organs contain a population of dormant stem cells (SCs) that are more primitive than other, already restricted, monopotent tissue-committed stem cells (TCSCs). These observations raise several questions, such as the developmental origin of these cells, their true pluripotent or multipotent nature, which surface markers they express, how they can be efficiently isolated from adult tissues, and what role they play in the adult organism. The phenotype of these cells and expression of some genes characteristic of embryonic SCs (ESCs), epiblast SCs (EPiSCs), and primordial germ cells (PGCs) suggests their early-embryonic deposition in developing tissues as precursors of adult SCs. In this review we will critically discuss all these questions and the concept that small dormant stem cells related to migratory PGCs, described as very small embryonic-like stem cells (VSELs), are deposited during embryogenesis in bone marrow and other organs as a backup population for adult tissue committed stem cells (TCSCs) and are involved in several processes related to tissue or organ rejuvenation, aging, and cancerogenesis. The most recent results on successful ex vivo expansion of human VSELs in chemically defined media free from feeder-layer cells opens up new and exciting possibilities for their application in regenerative medicine.

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Section: The Discovery Of Very Small Embryonic-like Stem Cells (Vselsmentioning

confidence: 55%

A Novel View of the Adult Stem Cell Compartment From the Perspective of a Quiescent Population of Very Small Embryonic-Like Stem Cells

et al. 2017

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“…2017). Following acute exercise, MSC content has been shown to decrease (Marycz et al . 2016), or remain unchanged (Niemiro et al .…”

Section: Discussionmentioning

confidence: 99%

“…MSCs have gained popularity as a potential source for cell therapy due to their multi-lineage differentiation potential, and their role in regulating tissue repair via paracrine mechanisms (Bartczak et al 2017). Following acute exercise, MSC content has been shown to decrease (Marycz et al 2016), or remain unchanged ; however, the effects of exercise training on circulating MSC content has not previously been evaluated. Our results reveal a trending decrease in the proportion of, and a decrease in the content of, reportedly adipose tissue derived fraction of CD34 + MSCs (Dominici et al 2006;Traktuev et al 2008), and a trend for a decrease in the reportedly bone marrow-derived CD34 − fraction of MSCs in individuals with obesity (Lin et al 2013).…”

Section: Figure 2 Eet Modifies Ccr2 and Tlr4 Expression On Hspcsmentioning

confidence: 99%

Effects of endurance exercise training on inflammatory circulating progenitor cell content in lean and obese adults

Niemiro

Allen

Mailing

et al. 2018

The Journal of Physiology

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Circulating progenitor cells (CPCs) and subpopulations are normally found in the bone marrow, but can migrate to peripheral tissues to participate in local inflammation and/or remodelling. The purpose of this study was to compare the CPC response, particularly the inflammatory-primed haematopoietic stem and progenitor (HSPC) subpopulation, to a 6 week endurance exercise training (EET) intervention between lean and obese adults. Seventeen healthy weight (age: 23.9 ± 5.4 years, body mass index (BMI): 22.0 ± 2.6 kg m ) and 10 obese (age: 29.0 ± 8.0 years, BMI: 33.1 ± 6.0 kg m ) previously sedentary adults participated in an EET. Blood was collected before and after EET for quantification of CPCs and subpopulations via flow cytometry, colony forming unit assays and plasma concentrations of C-X-C motif chemokine 12 (CXCL12), granulocyte-colony stimulating factor (G-CSF), and chemokine (C-C motif) ligand 2 (CCL2). Exercise training reduced the number of circulating HSPCs and adipose tissue-derived mesenchymal stem cells (AT-MSCs). EET increased the colony forming potential of granulocytes and macrophages irrespective of BMI. EET reduced the number of HSPCs expressing the chemokine receptor CCR2 and the pro-inflammatory marker TLR4. EET-induced changes in adipose tissue-derived MSCs and bone marrow-derived MSCs were negatively related to changes in absolute fitness. Our results indicate that EET, regardless of BMI status, decreases CPCs and subpopulations, particularly those primed for contribution to tissue inflammation.

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“…Endurance exercise helps in the expansion of developmentally early stem cells including SOX2 [43]. However, to our knowledge, studies on SOX2 methylation and exercise are limited.…”

Section: Introductionmentioning

confidence: 98%

Blood-Based SOX2-Promoter Methylation in Relation to Exercise and PM2.5 Exposure among Taiwanese Adults

Tantoh

Chou

et al. 2020

Cancers

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Increased ventilation during exercise in polluted areas could trigger airway inflammation. We evaluated blood DNA methylation of the SOX2-promoter region in relation to exercise and PM2.5 in Taiwanese adults. Data of 948 participants aged 30–70 years were retrieved from the Taiwan Biobank Database (2008–2015) and the Air Quality Monitoring Database (2006–2011). PM2.5 was positively associated with SOX2-promoter methylation (β = 0.000216; p < 0.0001). The interaction between PM2.5 and exercise on SOX2-promoter methylation was significant (p = 0.0146). After stratification by exercise habits, PM2.5 was positively associated with SOX2 methylation in only individuals who did regular exercise (β = 0.0003490; p < 0.0001). After stratification by exercise habits and residential areas, SOX2-promoter methylation levels in those who lived in the southern area were higher for both the regular exercise (β = 0.00272; p = 0.0172) and no regular exercise groups (β = 0.002610 and p = 0.0162). SOX2-promoter methylation levels in those who lived in the northern area and did regular exercise were lower; β = -0.00314 (p = 0.0036). In conclusion, PM2.5 was positively associated with SOX2-promoter methylation in participants who did regular exercise. Living in the southern area was positively associated with SOX2-promoter methylation regardless of exercise habits.

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Endurance Exercise Mobilizes Developmentally Early Stem Cells into Peripheral Blood and Increases Their Number in Bone Marrow: Implications for Tissue Regeneration

Cited by 53 publications

References 33 publications

A Novel View of the Adult Stem Cell Compartment From the Perspective of a Quiescent Population of Very Small Embryonic-Like Stem Cells

A Novel View of the Adult Stem Cell Compartment From the Perspective of a Quiescent Population of Very Small Embryonic-Like Stem Cells

Effects of endurance exercise training on inflammatory circulating progenitor cell content in lean and obese adults

Blood-Based SOX2-Promoter Methylation in Relation to Exercise and PM2.5 Exposure among Taiwanese Adults

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