Endowing polyetheretherketone with synergistic bactericidal effects and improved osteogenic ability

Yan, Jianglong; Zhou, Wenhao; Jia, Zhaojun; Xiong, Pan; Li, Yangyang; Wang, Pei; Li, Qiyao; Cheng, Yan; Zheng, Yufeng

doi:10.1016/j.actbio.2018.08.037

Cited by 61 publications

(48 citation statements)

References 61 publications

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“…In recent years, biological modification of PEEK implants had been attracted considerable attention in tissue engineering applications. In previous studies [ 10 , 14 , 47 ], the surface porous structure and fully three dimensionally porous structure was fabricated to enhance the bioactive of PEEK implant. However, the porous structures generated by those methods would reduce the mechanical strength of PEEK implants and it could not meet the demand of clinical applications.…”

Section: Resultsmentioning

confidence: 99%

Gaseous sulfur trioxide induced controllable sulfonation promoting biomineralization and osseointegration of polyetheretherketone implants

Wan

Zhang

Guo

et al. 2020

Bioactive Materials

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Fabricating a desired porous structure on the surface of biomedical polyetheretherketone (PEEK) implants for enhancing biological functions is crucial and difficult due to its inherent chemical inertness. In this study, a porous surface of PEEK implants was fabricated by controllable sulfonation using gaseous sulfur trioxide (SO 3 ) for different time (5, 15, 30, 60 and 90 min). Micro-topological structure was generated on the surface of sulfonated PEEK implants preserving original mechanical properties. The protein absorption capacity and apatite forming ability was thus improved by the morphological and elemental change with higher degree of sulfonation. In combination of the appropriate micromorphology and bioactive sulfonate components, the cell adhesion, migration, proliferation and extracellular matrix secretion were obviously enhanced by the SPEEK-15 samples which were sulfonated for 15 min. Finding from this study revealed that controllable sulfonation by gaseous SO 3 would be an extraordinarily strategy for improving osseointegration of PEEK implants by adjusting the microstructure and chemical composition while maintaining excellent mechanical properties.

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Section: Resultsmentioning

confidence: 99%

Gaseous sulfur trioxide induced controllable sulfonation promoting biomineralization and osseointegration of polyetheretherketone implants

Wan

Zhang

Guo

et al. 2020

Bioactive Materials

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“…Xie et al [ 15 ] found that due to the accumulation of intracellular Ag nanoparticles, their cytotoxicity often appears to be time-dependent after being cocultured for many days. Furthermore, studies have shown that silver nanoparticles have an effect on osteogenic activity [ 16 , 17 ]. Qin et al [ 18 ] found that 4 μ g/ml of silver nanoparticles showed significantly higher osteogenic ability than pure Ag + .…”

Section: Introductionmentioning

confidence: 99%

A Multifunctional Antibacterial and Osteogenic Nanomedicine: QAS-Modified Core-Shell Mesoporous Silica Containing Ag Nanoparticles

Qiu

Zhang

et al. 2020

BioMed Research International

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Treatments for infectious bone defects such as periodontitis require antibacterial and osteogenic differentiation capabilities. Nanotechnology has prompted the development of multifunctional material. In this research, we aim to synthesize a nanoparticle that can eliminate periodontal pathogenic microorganisms and simultaneously stimulate new bone tissue regeneration and mineralization. QAS-modified core-shell mesoporous silica containing Ag nanoparticles (Ag@QHMS) was successfully synthesized through the classic hydrothermal method and surface quaternary ammonium salt functionalization. The Ag@QHMS in vitro antibacterial activity was explored via coculture with Staphylococcus aureus, Escherichia coli, and Porphyromonas gingivalis biofilms. Bone mesenchymal stem cells (BMSCs) were selected for observing cytotoxicity, apoptosis, and osteogenic differentiation. Ag@QHMS showed a good sustained release profile of Ag+ and a QAS-grafted mesoporous structure. Compared with the single-contact antibacterial activity of QHMS, Ag@QHMS exhibited a more efficient and stable concentration-dependent antimicrobial efficacy; the minimum inhibitory concentration was within 100 μg/ml, which was below the BMSC biocompatibility concentration (200 μg/ml). Thus, apoptosis would not occur while promoting the increased expression of osteogenic-associated factors, such as runt-related transcription factor 2 (RUNX2), alkaline phosphatase (ALP), osteopontin (OPN), osteocalcin (OCN), bone sialoprotein (BSP), and collagen type 1 (COL-1). A safe concentration of particles can stimulate cell alkaline phosphatase and matrix calcium salt deposition. The dual antibacterial effect from the direct contact killing of QAS and the sustained release of Ag nanoparticles, along with the Ag-promoted osteogenic differentiation, had been verified and utilized in Ag@QHMS. This system demonstrates the potential for utilizing pluripotent biomaterials to treat complex lesions.

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“…Similarly, Ag NPs anchored to a PDA intermediate layer reduced the growth and biofilm formation of E. coli and S. aureus . Ag NPs incorporated in a silk fibroin and gentamicin sulfate coating on sulfonated PEEK also decreased the survival and attachment of S. aureus and E. coli to PEEK …”

Section: Strategies For Improving Antibacterial Activitymentioning

confidence: 93%

“…For example, physicochemical modifications and coatings, such as sandblasting, sulfonation, LbL film deposition, and TiO 2 coatings, have been applied to PEEK surfaces to enhance the physical adsorption of proteins and drugs that promote bone formation or to provide reactive groups to covalently attach additional proteins, peptides, and/or drugs . Common surface pretreatments to create reactive groups for the covalent attachment of biological molecules include PDA coatings and sulfonation . The noncovalent deposition of proteins on PEEK or surface‐treated PEEK can also provide sites for further biological functionalization, such as when the adsorption of collagen provided reactive sites for the covalent attachment of a bone‐forming protein through carbodiimide crosslinking chemistry …”

Section: Surface Modification Techniquesmentioning

confidence: 99%

Surface Modification Strategies to Improve the Osseointegration of Poly(etheretherketone) and Its Composites

Buck

Cerruti

2019

Macromolecular Bioscience

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In the last 5 years, a wide variety of surface modification strategies are explored to improve the integration of poly(etheretherketone) (PEEK) implants with bone. Since PEEK does not support bone on‐growth, its surface properties need to be tailored to promote osteogenesis at the bone‐implant interface. Surface modifications applied to achieve this response range from simple surface morphology changes to the deposition of osteoconductive coatings. Of the many methods, titanium and/or hydroxyapatite coatings, extrusion to create surface pores, and an accelerated neutral atom beam treatment have been approved by the U.S. Food and Drug Administration to improve the integration of PEEK spinal cages. The success of these surface modifications brings hope for the clinical translation of other techniques in the future, but there are several limitations that may be preventing other treatments from reaching the clinic. This review describes numerous strategies that have been applied to PEEK‐based implants for improving their osseointegration and enhancing their antibacterial properties. The review concludes with a discussion about future directions for the field and provides suggestions for advancing clinical translation of surface‐modified PEEK implants to improve the lives of patients in need of these implants.

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Endowing polyetheretherketone with synergistic bactericidal effects and improved osteogenic ability

Cited by 61 publications

References 61 publications

Gaseous sulfur trioxide induced controllable sulfonation promoting biomineralization and osseointegration of polyetheretherketone implants

Gaseous sulfur trioxide induced controllable sulfonation promoting biomineralization and osseointegration of polyetheretherketone implants

A Multifunctional Antibacterial and Osteogenic Nanomedicine: QAS-Modified Core-Shell Mesoporous Silica Containing Ag Nanoparticles

Surface Modification Strategies to Improve the Osseointegration of Poly(etheretherketone) and Its Composites

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