Endovascular Treatment of Intracranial Aneurysms Using Polymer Polyglycolic-Lactic Acid Coated Coils

Hwang, Sung Kyun; Kim, Sung Hak

doi:10.12771/emj.2012.35.1.38

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…[ 156 ] PGLA‐coated coils did not provide a better long‐term (≥ 12 months) recanalization rate than platinum coils in aneurysms treatment. [ 118 ] However, Hwang and Kim [ 157 ] declared that bioactive PGLA‐coated coils were found to be a safe method for recanalization in patients with intracranial aneurysms.…”

Section: Polymer Blendsmentioning

confidence: 99%

Single Component Polymers, Polymer Blends, and Polymer Composites for Interventional Endovascular Embolization of Intracranial Aneurysms

Karadeli,

Kuram

2023

Macromolecular Bioscience

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Intracranial aneurysm is the abnormal focal dilation in brain arteries. When untreated, it can enlarge to rupture points and account for subarachnoid hemorrhage cases. Intracranial aneurysms can be treated by blocking the flow of blood to the aneurysm sac with clipping of the aneurysm neck or endovascular embolization with embolics to promote the formation of the thrombus. Coils or an embolic device are inserted endovascularly into the aneurysm via a micro‐catheter to fill the aneurysm. Many embolization materials have been developed. An embolization coil made of soft and thin platinum wire called the “Guglielmi detachable coil” (GDC) enables safer treatment for brain aneurysms. However, patients may experience aneurysm recurrence because of incomplete coil filling or compaction over time. Unsatisfactory recanalization rates and incomplete occlusion are the drawbacks of endovascular embolization. So, the fabrication of new medical devices with less invasive surgical techniques is mandatory to enhance the long‐term therapeutic performance of existing endovascular procedures. For this aim, the current article reviews polymeric materials including blends and composites employed for embolization of intracranial aneurysms. Polymeric materials used in embolic agents, their advantages and challenges, results of the strategies used to overcome treatment, and results of clinical experiences are summarized and discussed.

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Section: Polymer Blendsmentioning

confidence: 99%