Endovascular Treatment of Intimomedial Mucoid Degeneration

Katz, Jeremy; West, Derek; Bui, James T.; Knuttinen, Grace; Chejfec, Gregorio; Owens, Charles

doi:10.1016/j.jvir.2008.08.019

Cited by 16 publications

(42 citation statements)

References 4 publications

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“…However, contrary to the present study no differences on IMT were found after CIH (Lan et al, 2013). The deposition of mucoid material within the intima and media of the arterial wall has also been described, and assumed to reflect a precipitating factor underlying vascular wall weakening and increased risk for aneurysm formation (Katz et al, 2008). Indeed, Arnaud et al evaluated aorta remodeling caused by CIH and showed enhanced mucoid accumulation between sub-intimal elastic fibers, which could result from elastin degeneration or mucoid degenerating vascular smooth muscle cells (Arnaud et al, 2011).…”

Section: Discussioncontrasting

confidence: 92%

Acetylsalicylic Acid Prevents Intermittent Hypoxia-Induced Vascular Remodeling in a Murine Model of Sleep Apnea

Suárez-Girón

Torres

Montserrat

et al. 2018

Sleep and Control of Breathing

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Study objectives: Chronic intermittent hypoxia (CIH), a hallmark feature of obstructive sleep apnea (OSA), induces accelerated atherogenesis as well as aorta vascular remodeling. Although the cyclooxygenase (COX) pathway has been proposed to contribute to the cardiovascular consequences of OSA, the potential benefits of a widely employed COX-inhibitor such (acetylsalicylic acid, ASA) on CIH-induced vascular pathology are unknown. Therefore, we hypothesized that a common non-selective COX inhibitor such as ASA would attenuate the aortic remodeling induced by CIH in mice. Methods: 40 wild-type C57/BL6 male mice were randomly allocated to CIH or normoxic exposures (N) and treated with daily doses of ASA or placebo for 6 weeks. At the end of the experiments, intima-media thickness (IMT), elastin disorganization (ED), elastin fragmentation (EF), length between fragmented fiber endpoints (LFF), aortic wall collagen abundance (AC) and mucoid deposition (MD) were assessed. Results: Compared to N, CIH promoted significant increases in IMT (52.58 ± 2.82 µm vs. 46.07 ± 4.18 µm, p < 0.003), ED (25.29 ± 14.60% vs. 4.74 ± 5.37%, p < 0.001), EF (5.80 ± 2.04 vs. 3.06 ± 0.58, p < 0.001), LFF (0.65 ± 0.34% vs. 0.14 ± 0.09%, p < 0.001), AC (3.43 ± 1.52% vs. 1.67 ± 0.67%, p < 0.001) and MD (3.40 ± 2.73 µm 2 vs. 1.09 ± 0.72 µm 2 , p < 0.006). ASA treatment mitigated the CIH-induced alterations in IMT: 44.07 ± 2.73 µm; ED: 10.57 ± 12.89%; EF: 4.63 ± 0.88; LFF: 0.25 ± 0.17% and AC: 0.90 ± 0.13% (p<0.05 for all comparisons). Conclusions: ASA prevents the CIH-induced aortic vascular remodeling, and should therefore be prospectively evaluated as adjuvant treatment in patients with OSA.

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Section: Discussioncontrasting

confidence: 92%

Acetylsalicylic Acid Prevents Intermittent Hypoxia-Induced Vascular Remodeling in a Murine Model of Sleep Apnea

Suárez-Girón

Torres

Montserrat

et al. 2018

Sleep and Control of Breathing

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“…Blunt or penetrating pelvic trauma are the most common causes of pseudo aneurysm, but some less commonly reported ones were iatrogenic causes, infection and atherosclerosis. They occur due to breaching and thinning of the arterial wall, after which these aneurysms are enclosed only by the adventitial layer [1,2,3,4 ]. Gluteal artery aneurysms are found to be more common on the left side with a male predominance.…”

Section: Discussionmentioning

confidence: 99%

“…Gluteal artery aneurysms are found to be more common on the left side with a male predominance. These lesions are considered as an emergency as they are liable to rupture at any time with life-threatening hemorrhage [3,5]. There are two pitfalls concerning the presentation of pseudo aneurysms of the SGA.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Superior Gluteal Artery Pseudo Aneurysm after Blunt Trauma

Trpeski

Ilieva

Apostolovska

et al. 2019

Prilozi

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Prevailing over in rotationally unstable pelvic fractures, acetabular fractures or hip dislocations, superior gluteal artery pseudo aneurysm imperceptibly could be found after blunt force trauma of the pelvic region. We present a case of superior gluteal artery pseudo aneurysm after blunt force trauma that became gradually symptomatic in two months following the prime malevolence. Non-resolving gluteal hematoma presented two months after the incident, disregarding standard treatment methods led the diagnosis to plausible entity of pseudo aneurysm. Standard protocol was followed. CT angiography was indicated and it confirmed the suspected diagnosis. Upon indication a treatment plan was established with correspondent angioembolization of the pathologic substrate. Pseudo aneurism of the superior gluteal artery should be considered as differential diagnosis for unexplained hematomas in the posterior pelvic region following a trauma regardless of its nature.

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“…Although the exact incidence is not known, fewer than 40 cases have been reported. Regardless, pseudoaneurysms are considered emergencies because they are liable to rupture at any time, with life-threatening hemorrhage10).…”

Section: Discussionmentioning

confidence: 99%