Endovascular Therapy for Acute Ischemic Stroke in Patients with Large-Vessel Occlusion due to Atherosclerotic Stenosis

Outcome Comparison of Endovascular Treatment for Acute Large Vessel Occlusion Due to Large Artery Atherosclerosis and Cardioembolism in the Chinese Population: Data from the ANGEL Registry

“…LAA and CE were the two main etiologies of LVO according to the TOAST standard. In the present study, the rate of LAA was higher than that of CE, which was different from the SITS registry, 3 MR CLEAN registry, 4 RESCUE-Japan Registry 2, 7 and Bernese Stroke Registry. 5 However, this result aligned with another Chinese registry, ANGEL-ACT registry, 8 which reflected the distribution of TOAST classification of LVO in China.…”

“…Similarly, a previous systematic review and meta-analysis further supported this trend, highlighting CE among whites and LAA among Asians as the predominant causes of ischemic stroke. 15 Another finding of our study was that the efficacy and safety of EVT were not significantly different between LVO patients with LAA and CE, which was also found in RESCUE-Japan Registry 2, 7 Bernese Stroke Registry, 5 ANGEL-ACT registry, 8 and a meta-analysis including 25 studies. 3 Conversely, SITS registry indicated that a lower rate of functional independence in LVO patients with LAA than those with CE.…”

“…[3][4][5][6] However, the literature on this topic in the Asian population still remains scarce. 7,8 Hence, the present study based on a nationwide, multicenter, prospective registry database in China, aimed to compare baseline characteristics and clinical outcomes after EVT for anterior circulation LVO stemming from LAA and CE.…”

Association of time to groin puncture with patient outcome after endovascular therapy stratified by etiology

“…Hwang et al demonstrated that the OR of favorable outcome in patients with a poor collateral status significantly dropped as onset to reperfusion time or puncture to reperfusion time increased, while no such association was found in patients with good collaterals (Hwang et al, 2015). Shirakawa et al (2021) previously reported the discrepancy in time-dependent benefit by stroke etiology in a Japanese Registry. However, without complete perfusion evaluation at baseline, the study was not able to explore further behind the phenomena.…”

Multi-assessment of critical steno-occlusive middle cerebral arteries: transcranial Doppler combined with magnetic resonance angiography

“…Currently, endovascular recanalization has changed the therapeutic framework of intracranial vessel occlusion. Selected cerebral ischemic individuals can benefit from endovascular therapy with good revascularization and favorable outcomes [ 3 , 4 ]. In this context, accurate assessment of severe stenosis and occlusion of the MCA is extremely essential before making optimal therapeutic decisions, including best medical treatment, balloon angioplasty, stenting and mechanical thrombectomy.…”