Endovascular Techniques in Limb Salvage: Cutting, Cryo, Brachy, and
                        Drug-Eluting Balloons

Anaya‐Ayala, Javier E.

doi:10.14797/mdcj-9-2-69

Cited by 13 publications

(7 citation statements)

References 32 publications

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“…To the best of our knowledge, there are few studies on the pathogenesis of restenosis after LEAD. Our previous studies found a unique mechanism of restenosis which was in consistence with others 22,23 and demonstrated that the excessive proliferation and migration of VSMCs from the media to the intima were the main cause of restenosis 8 . In the present study, the potential pathogenesis was further investigated and we found that Lin28a played a crucial role in regulating the proliferation and migration of VSMCs in restenosis.…”

Section: Discussionsupporting

confidence: 79%

Lin28a up‐regulation is associated with the formation of restenosis via promoting proliferation and migration of vascular smooth muscle cells

Zou

Zhou

Zhang

et al. 2020

J Cellular Molecular Medi

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To explore the potential role of Lin28a in the development of restenosis after percutaneous transluminal angioplasty, double‐balloon injury surgery and mono‐balloon injury surgery were used to establish restenosis and atherosclerosis models, respectively, so as to better distinguish restenosis from atherosclerotic lesions. Immunohistochemical analysis revealed that significantly higher expression of Lin28a was observed in the iliac arteries of restenosis plaques than that of atherosclerosis plaques. Immunofluorescence studies showed the colocalization of Lin28a with α‐smooth muscle actin in restenosis plaques, rather than in atherosclerosis plaques, which suggested that Lin28a might be related to the unique behaviour of vascular smooth muscle cells (VSMCs) in restenosis. To further confirm above hypothesis, Lin28a expression was up‐regulated by transfection of Lenti‐Lin28a and inhibited by Lenti‐Lin28a‐shRNA transfection in cultured VSMCs, and then the proliferation and migration capability of VSMCs were detected by EdU and Transwell assays, respectively. Results showed that the proliferation and migration of VSMCs were significantly increased in accordance with the up‐regulation of Lin28a expression, while above behaviours of VSMCs were significantly suppressed after inhibiting the expression of Lin28a. In conclusion, the up‐regulation of Lin28a exerts its modulatory effect on VSMCs’ proliferation and migration, which may play a critical role in contributing to pathological formation of restenosis.

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Section: Discussionsupporting

confidence: 79%

Lin28a up‐regulation is associated with the formation of restenosis via promoting proliferation and migration of vascular smooth muscle cells

Zou

Zhou

Zhang

et al. 2020

J Cellular Molecular Medi

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“…The cryotherapy is thought to improve vessel compliance by breaking down collagen fibrils and induce apoptosis of the smooth muscle cells within the vessel walls. 23 Several studies have shown cryoplasty to be less effective than conventional angioplasty in fempop and infrapopliteal lesions. 24 25 26 The clinical benefit of using cryoplasty remains in doubt; therefore, further studies are required to determine its efficacy especially given the associated high cost.…”

Section: Cryoplastymentioning

confidence: 99%

Treatment of Difficult, Calcified Lesions: Plaque Modification Strategies

Haddad

Scheidt

2023

Semin intervent Radiol

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Endovascular management of peripheral arterial disease is continually evolving. Most changes focus on addressing the challenges that hinder optimal patient outcomes; one of the most significant is how to best treat calcified lesions. Hardened plaque results in a variety of technical issues including impaired device delivery, decreased luminal revascularization, poor stent expansion, heightened risk of in-stent stenosis or thrombosis, and increased procedural time and cost. For this reason, plaque modification devices have been developed to mitigate this issue. This paper will describe these strategies and provide the reader with an overview of devices that can be used to treat chronically hardened lesions.

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“…These are low-pressure balloon catheters with three or four microsurgical blades which are mounted longitudinally on the balloon and which can cut the blood vessel plaque in a controlled manner during initial balloon inflation [28]. During inflation elastic recoil, restenosis, inflammatory response, endothelial damage and vascular smooth muscle cell proliferation [29] are reduced.…”

Section: Cutting Balloon Angioplastymentioning

confidence: 99%

Drug-eluting balloon: design, technology and clinical aspects

2018

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A drug-eluting balloon is a non-stent technology in which the effective homogenous delivery of anti-proliferative drugs is processed by the vessel wall through an inflated balloon. This is done to restore luminal vascularity in order to treat atherosclerosis, in-stent restenosis and reduce the risk of late thrombosis without implanting a permanent foreign object. The balloon technology relies on the concept of targeted drug delivery, which helps in the rapid healing of the vessel wall and prevents the proliferation of smooth muscle cells. Several drug eluting devices in the form of coated balloons are currently in clinical use, namely DIOR, PACCOCATH, SeQuentPlease and IN.PACT™. The device varies in terms of the material used for making the balloon, the coating techniques, the choice of coated drug and the release pattern of the drug at the site. This review gives an insight into the evolution, rationale and comparison of the marketed drug-eluting balloons. Here, different coating techniques have been analysed for the application and critical analysis of available DEB technologies, and a technical comparison has been done.

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Endovascular Techniques in Limb Salvage: Cutting, Cryo, Brachy, and Drug-Eluting Balloons

Cited by 13 publications

References 32 publications

Lin28a up‐regulation is associated with the formation of restenosis via promoting proliferation and migration of vascular smooth muscle cells

Lin28a up‐regulation is associated with the formation of restenosis via promoting proliferation and migration of vascular smooth muscle cells

Treatment of Difficult, Calcified Lesions: Plaque Modification Strategies

Drug-eluting balloon: design, technology and clinical aspects

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