Endovascular Broad-Neck Aneurysm Creation in a Porcine Model Using a Vascular Plug

Mühlenbruch, Georg; Nikoubashman, Omid; Steffen, Björn; Dadak, Mete; Palmowski, Moritz; Wiesmann, Martin

doi:10.1007/s00270-012-0431-z

Cited by 8 publications

(7 citation statements)

References 12 publications

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“…There is a variety of access catheters, ranging from small (5F-7F) guiding catheters to large-bore sheath catheters (8F) and BGCs, but there is no consensus about which access catheter is most suitable. 4,8,[11][12][13] Mechanical thrombectomy is becoming more common, and many interventionalists must decide which technique to choose. Because empiric data are lacking and large randomized prospective studies are needed to resolve this issue from a clinical point of view, we addressed this question with a simple technical approach.…”

mentioning

confidence: 99%

Balloon-Guide Catheters Are Needed for Effective Flow Reversal during Mechanical Thrombectomy

Nikoubashman¹,

Wischer²,

Hennemann³

et al. 2018

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Blood flow management in the carotid artery during mechanical thrombectomy is crucial for safety and effectiveness. There is an ongoing discussion about whether balloon-guide catheters or large-bore sheaths are needed for effective flow management. We compared general flow characteristics of proximal aspiration through a large-bore sheath and a balloon-guide catheter in a porcine in vivo model. MATERIALS AND METHODS: We investigated blood flow in a porcine common carotid artery with and without aspiration (VacLok syringe and Penumbra pump, Pump MAX) through an 8F-long sheath and an 8F balloon-guide catheter. Blood hemodynamics were assessed via continuous duplex sonography. RESULTS: Average vessel diameter and baseline blood flow were 4.4 Ϯ 0.2 mm and 244 Ϯ 20 mL/min, respectively. For the 8F sheath, pump aspiration resulted in a significant flow reduction (225 Ϯ 25 mL/min, P Ͻ .001), but with a persisting antegrade stream. Manual aspiration resulted in collapse of the vessel in 2 of 7 measurements and oscillatory flow with antegrade systolic and retrograde diastolic components in the remaining 5 measurements. Net flow was antegrade (52 Ϯ 44 mL/min) in 3 and retrograde (Ϫ95 Ϯ 52 mL/min) in the remaining 2 measurements. For balloon-guide catheters, balloon inflation always resulted in flow arrest. Additional pump or manual aspiration resulted in significant flow reversal of Ϫ1100 Ϯ 230 and Ϫ468 Ϯ 46 mL/min, respectively (both, P Ͻ .001). CONCLUSIONS: Only balloon-guide catheters allow reliable blood flow arrest and flow reversal in combination with aspiration via syringes or high-flow pump systems. Aspiration through an 8F sheath results in either collapse of the vessel or oscillatory flow, which can result in a net antegrade or retrograde stream.

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mentioning

confidence: 99%

Balloon-Guide Catheters Are Needed for Effective Flow Reversal during Mechanical Thrombectomy

Nikoubashman¹,

Wischer²,

Hennemann³

et al. 2018

AJNR Am J Neuroradiol

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“…[ 114 ] 2012 X Surgical Dogs Saccular X Darsaut T.E. [ 115 ] 2012 X Surgical Dogs Saccular X Marbacher S. [ 116 ] 2012 X Surgical Rabbits Saccular X Mühlenbruch G. [ 117 ] 2013 X Surgical Swines Saccular X Struffert T. [ 118 ] 2013 X Surgical Rabbits Saccular X X …”

Section: Methodsmentioning

confidence: 99%

Imaging of intracranial aneurysms in animals: a systematic review of modalities

et al. 2023

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Intracranial aneurysm (IA) animal models are paramount to study IA pathophysiology and to test new endovascular treatments. A number of in vivo imaging modalities are available to characterize IAs at different stages of development in these animal models. This review describes existing in vivo imaging techniques used so far to visualize IAs in animal models. We systematically searched for studies containing in vivo imaging of induced IAs in animal models in PubMed and SPIE Digital library databases between 1 January 1945 and 13 July 2022. A total of 170 studies were retrieved and reviewed in detail, and information on the IA animal model, the objective of the study, and the imaging modality used was collected. A variety of methods to surgically construct or endogenously induce IAs in animals were identified, and 88% of the reviewed studies used surgical methods. The large majority of IA imaging in animals was performed for 4 reasons: basic research for IA models, testing of new IA treatment modalities, research on IA in vivo imaging of IAs, and research on IA pathophysiology. Six different imaging techniques were identified: conventional catheter angiography, computed tomography angiography, magnetic resonance angiography, hemodynamic imaging, optical coherence tomography, and fluorescence imaging. This review presents and discusses the advantages and disadvantages of all in vivo IA imaging techniques used in animal models to help future IA studies finding the most appropriate IA imaging modality and animal model to answer their research question.

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“…Disadvantages are the surgical trauma required for induction, at least transient presence of suture threads, and the venous structure of the aneurysmal wall. 20 Aneurysms emerging from artificial implants provide good training opportunities for endovascular treatments such as coiling, 19 but are expensive 23 and come at the risk of thrombus formation within the implant. Hybrid models connecting an artificial vascular tree with multiple aneurysms to an animal's circulation are also available for neurointerventional training purpose.…”

Section: Aneurysm Modelsmentioning

confidence: 99%

Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations

Herrmann

Meckel

Gounis

et al. 2019

J Cereb Blood Flow Metab

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Neuroendovascular procedures have led to breakthroughs in the treatment of ischemic stroke, intracranial aneurysms, and intracranial arteriovenous malformations. Due to these substantial successes, there is continuous development of novel and refined therapeutic approaches. Large animal models feature various conceptual advantages in translational research, which makes them appealing for the development of novel endovascular treatments. However, the availability and role of large animal models have not been systematically described so far. Based on comprehensive research in two databases, this systematic review describes current large animal models in neuroendovascular research including their primary use. It may therefore serve as a compact compendium for researchers entering the field or looking for opportunities to refine study concepts. It also describes particular applications for ischemic stroke and aneurysm therapy, as well as for the treatment of arteriovenous malformations. It focuses on most promising study designs and readout parameters, as well as on important pitfalls in endovascular translational research including ways to circumvent them.

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Endovascular Broad-Neck Aneurysm Creation in a Porcine Model Using a Vascular Plug

Abstract: The new porcine aneurysm model proved to be a straightforward approach that offers a wide range of training and scientific applications that might help further improve endovascular coil embolization therapy in patients with cerebral aneurysms.

Cited by 8 publications

References 12 publications

Balloon-Guide Catheters Are Needed for Effective Flow Reversal during Mechanical Thrombectomy

Balloon-Guide Catheters Are Needed for Effective Flow Reversal during Mechanical Thrombectomy

Imaging of intracranial aneurysms in animals: a systematic review of modalities

Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations

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