Endovascular Brachytherapy and Late Thrombotic Occlusion

Effects of Probucol Versus Aspirin and Versus Brachytherapy on Restenosis After Femoropopliteal Angioplasty:The PAB Randomized Multicenter Trial

“…2 The importance of positive remodeling in reducing restenosis produced by EVBT has been previously demonstrated by intravascular ultrasound in coronary patients 2 and recently con-firmed noninvasively by magnetic resonance imaging (MRI) in patients undergoing intravascular irradiation after angioplasty of the femoropopliteal arteries. 17 One of the major problems associated with vascular irradiation is the occurrence of late thrombotic occlusion in stented vessels, 18,19 which was confirmed by our recent report. 16 In the small number of patients receiving stents and randomized to EVBT, there was a 27% incidence of late acute stent thrombosis, which was synchronous with reduction of the double antiplatelet regimen.…”

Effects of Percutaneous Transluminal Angioplasty and Endovascular Brachytherapy on Vascular Remodeling of Human Femoropopliteal Artery by Noninvasive Magnetic Resonance Imaging

“…26 In addition to delayed reendothelialization, this may explain the increased risk of late thrombosis observed in patients treated with brachytherapy. 19,21 Although the exact mechanisms of the antirestenotic proper- ) and at 24 hours and 3 months after intervention. Shortly after intervention, similar enlargement of lumen area and expansion of vessel wall (outward remodeling) were seen in both groups.…”

Endovascular Brachytherapy after Percutaneous Transluminal Angioplasty of Recurrent Femoropopliteal Obstructions

“…Apparently, EVBT is beneficial in reducing the incidence of recurrence in short to medium-length postangioplasty neointimal restenoses as well as in de novo lesions. EVBT is still under serious scrutiny, despite numerous positive clinical reports, regarding concerns of late stent thrombosis, [22][23][24] the short duration of restenosis inhibition, development of sclerosis in the edge zones, and, last but not least, the unknown long-term sequelae of irradiation. [25][26][27] Our study supports the recommendation of EVBT as a possible preventive method after peripheral angioplasty, at least in patients with a high risk of recurrence.…”