Endovascular Aneurysm Repair

Pitton, Michael Bernhard; Schmenger, Ralf Patrick; Neufang, A.; Konerding, Moritz A.; Düber, Christoph; Thelen, M.

doi:10.1161/01.cir.0000014972.94443.ef

Cited by 18 publications

(2 citation statements)

References 34 publications

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“…At this point in time, judging the properties of an aneurysmal cavity by MRI is important. 24 Furthermore, cell transplantation under thoracoscope assistance may have an effect. This study has some limitations.…”

Section: Discussionmentioning

confidence: 99%

Development of a New Method for Endovascular Aortic Repair

Kajimoto

Shimono²,

Hirano³

et al. 2006

Circulation

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Background-Endovascular aortic repair by stent grafts (S/Gs) has been developed as a less invasive treatment for aortic aneurysms. However, some aneurysmal cavities can remain without organization, causing re-expansion. We demonstrated previously that transplantation of a cell combination (myoblasts and fibroblasts) promoted thrombus organization in a rat model. We also developed basic fibroblast growth factor (bFGF) slow-delivery S/Gs coated with elastin and impregnated with bFGF. Here, we evaluated the effects of cell transplantation combined with bFGF slow release on canine thoracic aortic aneurysmal sacs after S/Gs repair. Methods and Results-Thoracic aortic aneurysms were surgically created with jugular vein patches in 15 beagles.Myoblasts and fibroblasts of autologous skeletal muscle were isolated and cultured for cell transplantation. The S/Gs had 6 holes and produced endoleaks in the excluded cavities. Collagen gel (gel group, nϭ5) or a mixture of skeletal myoblasts and fibroblasts with collagen gel (cell group, nϭ5) were injected into the aneurysmal sacs excluded by the S/Gs. We also studied the effects of combined therapy of bFGF slow-release S/Gs and cell transplantation (hybrid group, nϭ5). After 14 days, histological analyses revealed that the excluded aneurysmal cavities of the gel group were filled with fresh thrombus, whereas the excluded cavities in the cell-transplanted groups were occupied by organized tissue. The percentages of the organized areas relative to the excluded cavities, evaluated by Masson's trichrome staining, were 18.1Ϯ4.0%, 52.6Ϯ4.0%, and 77.1Ϯ6.9% in the gel, cell, and hybrid groups, respectively. Collagen fibers had already appeared, and increased numbers of ␣-smooth muscle actin-positive cells were observed in the hybrid group. Conclusions-Cell

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Section: Discussionmentioning

confidence: 99%

Development of a New Method for Endovascular Aortic Repair

Kajimoto

Shimono²,

Hirano³

et al. 2006

Circulation

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“…eral modalities are used, including computed tomographic angiography (CTA), magnetic resonance angiography (MRA), or ultrasound examination. [1][2][3][4][5][6][7] CTA is the most widely employed imaging modality but has the drawback of iodinated contrast. Many patients have contrast allergies or renal insufficiency that prevents the use of contrast agents.…”

Section: Fig 1ࡗthementioning

confidence: 99%

Durability and Validity of a Remote, Miniaturized Pressure Sensor in an Animal Model of Abdominal Aortic Aneurysm

Milner¹,

Ruurda²,

Blankensteijn³

2004

Journal of Endovascular Therapy

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ࡗ ࡗPurpose: To investigate whether a remote, miniaturized pressure sensor could maintain calibration and function through organized thrombus over an extended period in a porcine model of abdominal aortic aneurysm (AAA). Methods: Six adult pigs had an AAA surgically created and excluded. A sensor zeroed to atmospheric pressure was placed within the aneurysm sac and another within the suprarenal aorta of each animal. Pressure measurements were taken at the initial operation and then on a weekly basis over 2 months. The aortic sensors were correlated to an intraarterial pressure catheter at the initial operation and at the time of sacrifice. Back-table sensor correlation with atmospheric pressure was done at the time of explantation. Results: Three animals died during the follow-up period. Five animals were available for 6-week follow-up, of which 3 survived for the complete 8-week protocol. Two of the surviving animals had an intra-aortic sensor. All 5 aneurysm sac sensors functioned throughout the experimental period. At the time of sacrifice, the sacs contained a large amount of organized thrombus in which the sac sensors were deeply embedded. The 3 aortic sensors also functioned throughout the course of the experiments. The pressures correlated within 5 mmHg to the catheter-based measurements taken at the initial operation and at the time of sacrifice. Comparison to atmospheric pressure revealed no calibration offset in any sensor.Conclusions: This chronic implantation study demonstrates the durability of a remote, miniaturized pressure sensor within a surgically created aneurysm sac as well as the suprarenal aorta of a porcine AAA model. There was no calibration offset in any of the sensors, and they remained valid at explantation. We believe that this is further evidence of the potential applicability of this sensor for clinical use. The current gold standard for evaluating the status of an excluded abdominal aortic aneurysm (AAA) after endovascular aneurysm repair (EVAR) is interval imaging studies. Sev-

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Diagnosis and management of endoleaks after endovascular aneurysm repair: role of MRI

Pitton¹

2005

Abdom Imaging

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Endovascular Aneurysm Repair

Cited by 18 publications

References 34 publications

Development of a New Method for Endovascular Aortic Repair

Development of a New Method for Endovascular Aortic Repair

Durability and Validity of a Remote, Miniaturized Pressure Sensor in an Animal Model of Abdominal Aortic Aneurysm

Diagnosis and management of endoleaks after endovascular aneurysm repair: role of MRI

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