Endotracheal Intubation Without Neuromuscular Blocking Agents: Is It a Good and Safe Option?

Akan, Mert; Öztekin, Sermin

doi:10.5812/anesthpain.3805

Cited by 1 publication

(1 citation statement)

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“…However, it is necessary to prescribe simultaneously a potent hypnotic, analgesic and muscle relaxant ( 2 - 4 ). Intubation and direct laryngoscopy can increase heart rate (HR) and blood pressure (BP), a phenomenon described as pressor response ( 5 - 7 ). Tachycardia and hypertension lead to an imbalance between the supply and demand of oxygen to the myocardial muscle, which can lead to ischemia, myocardial infarction and cardiac failure ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Comparison Between the Effects of Alfentanil, Fentanyl and Sufentanil on Hemodynamic Status During Rapid Sequence Intubation in the Emergency Department

et al. 2013

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Background:Laryngoscopy and tracheal intubation lead to the alteration of hemodynamic parameters, including blood pressure and heart rate, in traumatic patients who sustain rapid sequence intubation (RSI). Various drugs such as fentanyl, alfentanil and sufentanil have been used to modify these hemodynamic responses.Objectives:The aim of the present study is to compare the effects of fentanyl, sufentanil and alfentanil in trauma patients who require RSI in the emergency department (ED).Patients and Methods:This was a randomized double-blinded study conducted on 90 patients (18-65 years old, ASA I, II), who needed intubation following trauma. The patients were randomly divided into three groups, Group I, Group II and Group III, who have received alfentanil, fentanyl and sufentanil, respectively. Heart rate, blood pressure, saturation of peripheral oxygen and end-tidal carbon dioxide were measured 5 minutes before and 3, 5 and 10 minutes after intubation, respectively. The changes of the hemodynamic parameters were compared in between groups. Data were analyzed by One-way ANOVA, General Linear Model Repeated Measure and Mauchly’s Sphericity Test. A P < 0.05 was considered statistically significant.Results:There was no significant statistical difference among groups with respect to hemodynamic parameters.Conclusions:Alfentanil, fentanyl and sufentanil can be used safely as premedication drugs for trauma patients who need intubation.

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Section: Introductionmentioning

confidence: 99%