Endotracheal Inflammatory Pseudotumor: The Role of Interventional Bronchoscopy

Andrade, Filipe Moreira de; Abou-Mourad, Omar Moté; Júdice, Luiz Felippe; Carvalho-Filho, Antonio Bento C.B.; Schau, Bruno; Carvalho, Ângela Cristina Gouvêa

doi:10.1016/j.athoracsur.2010.06.013

Cited by 17 publications

(24 citation statements)

References 9 publications

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“…10 Inflammatory myofibroblastic tumors have rarely been reported in patients older than 16. 11 Tracheal inflammatory myofibroblastic tumor has rarely been reported in adults.…”

Section: Discussionmentioning

confidence: 99%

“…In the small number of patients having endobronchial lesions, the clinical presentation may be acute and serious due to post-obstruction pneumonia or symptoms associated with airway obstruction. 11,34 Superior vena cava syndrome was reported as a serious associated condition in one case report of inflammatory myofibroblastic tumor of the mediastinum. 35 The etiology of inflammatory myofibroblastic tumor is unclear, but trauma to the affected region secondary to inflammation has been proposed.…”

Section: Discussionmentioning

confidence: 99%

“…12 To our knowledge, only 11 adult tracheal inflammatory myofibroblastic tumors have been previously reported (Table). 11,[13][14][15][16][17][18][19][20][21][22] Apart from patients described in the Table, Lee et al reported 15 patients (mean age 31.3 y, range 7 months to 61 y) who underwent surgery for inflammatory myofibroblastic tumors, 4 of which were tracheal, 4 but the ages of those 4 patients were not stated.…”

Section: Discussionmentioning

confidence: 99%

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Adult Inflammatory Myofibroblastic Tumor of the Trachea: Case Report and Literature Review

Öztuna

Pehlivanlar²,

Abul³

et al. 2012

Respir Care

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Inflammatory myofibroblastic tumor of the trachea is a rare benign tumor in adults. It is mostly seen before the age of 16. We describe a 20-year-old female patient who presented with stridor. She had a fixed obstruction on spirometry, and computed tomography and bronchoscopy confirmed tracheal thickening and stenosis below the vocal cords and bronchial wall thickening at the level of the carina. Bronchoscopic biopsy confirmed an inflammatory myofibroblastic tumor. She recovered after mechanical dilatation and resection via rigid bronchoscopy, followed by corticosteroid therapy.

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“…10 Inflammatory myofibroblastic tumors have rarely been reported in patients older than 16. 11 Tracheal inflammatory myofibroblastic tumor has rarely been reported in adults.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Adult Inflammatory Myofibroblastic Tumor of the Trachea: Case Report and Literature Review

Öztuna

Pehlivanlar²,

Abul³

et al. 2012

Respir Care

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“…(6,19) Regarding the relationship between elastic fibers and surgical procedures involving the airways, new findings have emerged from recently attempted experiments involving tracheal the airways. (10,12,23) The nutritional status of several of these patients is abnormal; therefore, a deeper and more detailed understanding of the effects of malnutrition on the trachea is necessary. In addition, especially in developing countries, a poor socioeconomic status can lead to malnutrition during different periods of life, such as gestation, suckling, and weaning (or even later), and the effects of malnutrition on the organs might be irreversible.…”

Section: Discussionmentioning

confidence: 99%

“…(9) We consider that the lack of studies on this topic is relevant, since procedures involving the trachea and the airways are emerging and becoming more complex. Tracheal resection with anastomosis, the utilization of a wide range of airway stents, and, recently, the attempts at tracheal transplantation and replacement with allografts (10)(11)(12) make it essential to improve the understanding of the extracellular matrix. In addition, the effects of protein malnutrition on tracheal histology are worth studying, given the prevalence of this condition in hospitalized patients, especially in those in developing countries.…”

Section: Introductionmentioning

confidence: 99%

Desnutrição materna durante a lactação em ratos Wistar: efeitos sobre as fibras elásticas da matriz extracelular na traqueia dos filhotes

et al. 2012

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Objective: To investigate the effects of maternal protein malnutrition during lactation on the elastic fibers in the tracheas of Wistar rat pups. Methods: At delivery, 12 male pups of two Wistar rat dams were equally divided into two groups: control, in which the dam received water and standard rat chow ad libitum during lactation; and protein-restricted (PR), in which the dam received water ad libitum and an isoenergetic PR diet (8% protein). At 21 days of age, the pups were killed and their tracheas were excised. The elastic fibers were stained with Weigert's resorcin-fuchsin (after oxidation) and evaluated under light microscopy. Morphometric determinations were performed by stereology, with the point-counting method, and expressed as volumetric densities. Results: Elastic fibers, most having a longitudinal distribution, were identified beneath the tracheal mucosa. In addition, well-defined circular layers of elastic fibers were found around the inner and outer surfaces of the cartilaginous ring. There were no differences between the groups regarding the organization and distribution of the elastic fibers. The volumetric density of the elastic fibers of the pups in the control and PR groups was 2.46 ± 0.99% and 3.25 ± 1.13%, respectively (p < 0.01). Conclusions: The volumetric density of elastic fibers appears to be greater in rat pups breastfed by dams receiving a PR diet than in those breastfed by dams receiving a normal diet.Keywords: Trachea/growth and development; Trachea/anatomy and histology; Extracellular matrix; Airway remodeling; Malnutrition. ResumoObjetivo: Investigar os efeitos da desnutrição proteica materna durante a lactação sobre as fibras elásticas da traqueia de filhotes de ratos Wistar. Métodos: Ao nascimento, 12 filhotes machos de duas ratas Wistar foram igualmente divididos em dois grupos: grupo controle, cuja mãe recebeu água e dieta padrão de laboratório ad libitum durante a lactação, e grupo restrição proteica (RP), cuja mãe recebeu água ad libitum e dieta isoenergética com RP (8% de proteína). Aos 21 dias de vida, os filhotes foram sacrificados, e suas traqueias foram ressecadas. As fibras elásticas foram coradas pelo método de resorcina-fucsina de Weigert (precedido de oxidação) e avaliadas sob microscopia óptica. As determinações morfométricas foram feitas por estereologia, utilizando o método de contagem de pontos, e expressas em densidade volumétrica. Resultados: As fibras elásticas foram identificadas abaixo da mucosa traqueal, sendo a maioria em distribuição longitudinal. Além disso, camadas circulares bem definidas de fibras elásticas envolviam as superfícies interna e externa do anel cartilaginoso. Não houve diferenças entre os grupos quanto à organização e distribuição das fibras elásticas. A densidade volumétrica das fibras elásticas dos filhotes nos grupos controle e RP foi de, respectivamente, 2,46 ± 0,99% e 3,25 ± 1,13% (p < 0,01). Conclusões: Nossos resultados sugerem que a densidade volumétrica de fibras elásticas é maior em filhotes de ratos alimentados por fê...

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Endotracheal inflammatory myofibroblastic tumour: A rare cause of central airway occlusion in adults

Anthony

Singh

et al. 2022

Respirology Case Reports

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Inflammatory myofibroblastic tumour (IMT) is an unusual myofibroblastic spindle cell neoplasm that is rarely discovered in the airway of adults. Previously, it was regarded as a reactive lesion and was infamously known as inflammatory pseudotumour before recent insights revealed that significant majority of cases harboured neoplastic genes. Diagnosis is difficult as clinical presentation and imaging findings are non‐specific. Diagnosis and a favourable prognosis require the complete resection of the tumour. Detection of the anaplastic lymphoma kinase expression via immunohistochemistry expedites diagnosis. We report a young adult with an endotracheal mass occluding the central airway. The patient successfully underwent bronchoscopic resection using interventional techniques. IMT was diagnosed. No recurrence was seen after a year of surveillance. Due to the rarity of the disease, the recurrence rates for large airway disease is unknown. Recurrence rates for pulmonary lesions is reported to be lower compared to extrapulmonary IMTs and recurrence is unlikely if compete surgical excision is achieved.

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Endotracheal Inflammatory Pseudotumor: The Role of Interventional Bronchoscopy

Cited by 17 publications

References 9 publications

Adult Inflammatory Myofibroblastic Tumor of the Trachea: Case Report and Literature Review

Adult Inflammatory Myofibroblastic Tumor of the Trachea: Case Report and Literature Review

Desnutrição materna durante a lactação em ratos Wistar: efeitos sobre as fibras elásticas da matriz extracelular na traqueia dos filhotes

Endotracheal inflammatory myofibroblastic tumour: A rare cause of central airway occlusion in adults

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