Endotoxin-induced prostaglandin release and corpus luteum function in goats

Fredriksson, G.; Kindahl, H.; Edqvist, L.‐E.

doi:10.1016/0378-4320(85)90077-6

Cited by 59 publications

(30 citation statements)

References 16 publications

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“…Prostaglandin F 2α metabolite concentrations have been reported to be a reliable and sensitive marker of endotoxin release in cattle, pigs and goats (Fredriksson, 1984, Fredriksson et al, 1985and Holst et al, 1993. We did not quantify the systemic concentrations of endotoxin in this study but instead measured PGM as an indicator for the release of endotoxin into the bloodstream due to the massive infection in the uterus during pyometra.…”

Section: Higher Pgm Concentrations In Dogs With Pyometra Correlated Wmentioning

confidence: 99%

Increased concentrations of C-reactive protein but not high-mobility group box 1 in dogs with naturally occurring sepsis

Karlsson

Wernersson

Ambrosen

et al. 2013

Veterinary Immunology and Immunopathology

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Sepsis is difficult to diagnose and remains a common mortality cause worldwide in both humans and animals. The uterine infection pyometra causes sepsis in more than half of affected dogs and therefore allows the natural physiological development of sepsis to be studied. To find a sepsis-specific biochemical marker that could be combined with conventional clinical criteria for a more robust and quick diagnosis of sepsis, we measured systemic concentrations of high-mobility group box 1 (HMGB1) in 23 healthy control dogs and in 27 dogs with pyometra, 74% of which had sepsis.We also measured concentrations of the major acute phase protein C-reactive protein (CRP) and an indicator for endotoxaemia, prostaglandin F 2α metabolite (PGM) to assess the relative contribution of HMGB1 to the detection of systemic inflammation and endotoxaemia. We found that HMGB1 concentrations, in line with concentrations of CRP and PGM, were significantly increased in dogs with pyometra, and that concentrations of CRP, but not HMGB1, were significantly higher in dogs with sepsis compared to dogs without sepsis. Although serum HMGB1 did not differ between dogs with or without sepsis and was not correlated with either CRP or PGM concentrations, HMGB1 was correlated with the total white blood cell counts, suggesting an independent regulation and involvement in inflammation.

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Section: Higher Pgm Concentrations In Dogs With Pyometra Correlated Wmentioning

confidence: 99%

Increased concentrations of C-reactive protein but not high-mobility group box 1 in dogs with naturally occurring sepsis

Karlsson

Wernersson

Ambrosen

et al. 2013

Veterinary Immunology and Immunopathology

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“…Two groups of 4 (Roberts, 19711. Experimental intrauterine infections at different stages of the luteal phase also affect the length of the oestrous cycle (Brinsfield et al, 1969 (Brinsfield and Hawk, 1968a ;Brinsfield, Higginbotham and Hawk, 1969). Such a mechanism apparently operates at least partly through the local utero-ovarian pathway (Brinsfield and Hawk, 1968b (Fredriksson, Kindahl and Edquist, 1985 …”

mentioning

confidence: 99%

Effects of intrauterine infection by Staphylococcus aureus and Mycoplasma capricolum on the fertility of Nubian goats

Shallali¹,

Homeida²,

Dafalla³

1987

Reprod. Nutr. Dévelop.

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“…It was not unexpected to find that PGF 2α metabolite levels were elevated following LPS. It has earlier been demonstrated that LPS stimulates the synthesis and release of prostaglandin in several species (Fredriksson et al. 1985; van Miert 1985; Cort et al.…”

Section: Discussionmentioning

confidence: 99%

Postovulatory Effect of Intravenous Administration of Lipopolysaccharide (Escherichia coli, O55:B5) on the Endocrine Status of Recently Ovulated Sows

Mwanza¹,

Madej²,

Kindahl³

et al. 2001

Reprod Domest Anim

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The effects of lipopolysaccharide (Escherichia coli, O55:B5), administered 18 h after ovulation in the second oestrus after weaning on the hormonal profiles in 14 Swedish cross-bred (Landrace x Yorkshire) multiparous sows were studied. The endotoxin group (E-group) sows were administered with 300 ng/kg of lipopolysaccharide (LPS) whereas the control group (C-group) sows were administered 5 ml of saline intravenously via an indwelling jugular cannula. Blood samples for hormonal analyses were collected from all sows until slaughter. In the E-group, progesterone, cortisol and prostaglandin F(2 alpha) metabolite levels increased significantly (p < 0.05) following LPS compared with the C-group. It can be concluded from this study that apart from elevating cortisol and prostaglandin F(2 alpha) metabolite, LPS also elevates progesterone levels.

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Endotoxin-induced prostaglandin release and corpus luteum function in goats

Cited by 59 publications

References 16 publications

Increased concentrations of C-reactive protein but not high-mobility group box 1 in dogs with naturally occurring sepsis

Increased concentrations of C-reactive protein but not high-mobility group box 1 in dogs with naturally occurring sepsis

Effects of intrauterine infection by Staphylococcus aureus and Mycoplasma capricolum on the fertility of Nubian goats

Postovulatory Effect of Intravenous Administration of Lipopolysaccharide (Escherichia coli, O55:B5) on the Endocrine Status of Recently Ovulated Sows

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