Endotoxin-induced heart dysfunction in rats: Assessment of myocardial perfusion and permeability and the role of fluid resuscitation*

Chagnon, Frédéric; Bentourkia, M’hamed; Lecomte, Roger; Lessard, Michel; Lesur, Olivier

doi:10.1097/01.ccm.0000190622.02222.df

Cited by 60 publications

(33 citation statements)

References 40 publications

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“…74 On the other hand, myocardial ischemia in susceptible areas is induced by NO inhibition, hence reducing coronary blood flow. 75 Overall, any mismatch of perfusion to oxygen consumption ratio occurring in septic patients is liable to induce patchy microareas of myocardial damage with troponin I release, 76 because of the limited available myocardial oxygen extraction reserve.…”

Section: The Heart In Sepsismentioning

confidence: 99%

Review article: Organ per fusion/permeabilityrelated effects of norepinephrine and vasopressin in sepsis

Farand¹,

Hamel

Lauzier

et al. 2006

Can J Anesth/J Can Anesth

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Purpose:One invariable hallmark of severe sepsis is generalized tissue "malperfusion" and hyperpermeability secondary to microcirculatory/capillary leakage. This review focuses on direct and/or indirect influences of norepinephrine, as a standard of care, and vasopressin, as an alternative vasoactive drug, on organ and tissue perfusion/permeability in severe sepsis.Source: English and French language articles and books published between 1966 and 2005 were identified through a computerized Medline search using the terms "sepsis, permeability, norepinephrine and vasopressin". Relevant publications were retrieved and scanned for additional sources. Principal findings:There are few randomized clinical trials comparing different vasopressors in sepsis; most available literature consists of clinical reports, animal experiments and occasional reviews. Based on the best current evidence from these sources, we describe the status of major organ perfusion/ permeability in sepsis (i.e., the lung, the kidney, the heart, the intestine/gut) in the context of sepsis-induced organ dysfunction/failure. Potential and differential therapeutic effects of the vasopressors norepinephrine and arginine-vasopressin, in the setting of sepsis, are identified. Conclusions:In the treatment of sepsis, arginine-vasopressin exhibits organ-specific heterogeneity in vascular responsiveness, compared to norepinephrine. While norepinephrine is a current standard of care in sepsis, arginine-vasopressin shows promise for the treatment of septic shock. Objectif

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Section: The Heart In Sepsismentioning

confidence: 99%

Review article: Organ per fusion/permeabilityrelated effects of norepinephrine and vasopressin in sepsis

Farand¹,

Hamel

Lauzier

et al. 2006

Can J Anesth/J Can Anesth

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“…Moreover, animal studies and human observations [6][7][8] have indicated that myocardial dysfunction occurs globally. Sepsis-related myocardial dysfunction does not relate to myocardial ischemia or necrosis but is associated with cytokine-induced myocardial depression [5] and myocardial oedema, the later due to increased vascular permeability and leakage [9,10]. In sepsis both systolic and diastolic bi-ventricular myocardial dysfunction may be present [1,11,12].…”

Section: Introductionmentioning

confidence: 99%

Cardiac Arrhythmias in a Septic ICU Population: A Review

Schwartz

Brotfain

Koyfman

et al. 2015

The Journal of Critical Care Medicine

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Progressive cardiovascular deterioration plays a central role in the pathogenesis of multiple organ failure (MOF) caused by sepsis. Evidence of various cardiac arrhythmias in septic patients has been reported in many published studies. In the critically ill septic patients, compared to non-septic patients, new onset atrial fibrillation episodes are associated with high mortality rates and poor outcomes, amongst others being new episodes of stroke, heart failure and long vasopressor usage. The potential mechanisms of the development of new cardiac arrhythmias in sepsis are complex and poorly understood. Cardiac arrhythmias in critically ill septic patients are most likely to be an indicator of the severity of pre-existing critical illness.

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“…Figura 1. los mecanismos que explican la disfunción miocárdica durante la sepsis son múltiples y probablemente actúan sinérgicamente para dar origen a las manifestaciones clínicas propias de esta disfunción, siendo la más característica la disminución de la fracción de eyección del ventrículo izquierdo. Cambios micro-circulatorios La inflamación microvascular se asocia a edema intersticial miocárdico y compromiso directo de las fibras contráctiles, que contribuyen a la caída de la distensibilidad y función miocárdica 7,38 . Aunque el flujo coronario está aumentado en la sepsis, el flujo microcirculatorio parece estar afectado por edema endotelial y depósitos de fibrina que enlentecen u obstruyen el flujo microvascular 39 .…”

Section: Inflamaciónunclassified

Disfunción miocárdica en la sepsis

Andresen

Regueira

2010

Rev. méd. Chile

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Endotoxin-induced heart dysfunction in rats: Assessment of myocardial perfusion and permeability and the role of fluid resuscitation*

Abstract: Endotoxin can induce reversible myocardial alterations with evidence of coronary hypoperfusion and heart wall enlargement/damage, some of which can be prevented by fluid resuscitation. The use of crystalloids is less beneficial than pentastarch.

Cited by 60 publications

References 40 publications

Review article: Organ per fusion/permeabilityrelated effects of norepinephrine and vasopressin in sepsis

Review article: Organ per fusion/permeabilityrelated effects of norepinephrine and vasopressin in sepsis

Cardiac Arrhythmias in a Septic ICU Population: A Review

Disfunción miocárdica en la sepsis

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