Endotoxin and tumor necrosis factor-receptor levels in portal and hepatic vein of patients with alcoholic liver cirrhosis receiving elective transjugular intrahepatic portosystemic shunt

Abstract

Endotoxin levels correlated with hemodynamic derangement in cirrhotic severe portal hypertension, and with levels of soluble TNFα-receptors. Soluble TNFα-receptor levels correlated with the severity of liver dysfunction. However, in this study an endotoxin concentration gradient across the liver was absent, suggesting negligible primary hepatic endotoxin elimination in the absence of complications.

Acute decompensation boosts hepatic collagen type III deposition and deteriorates experimental and human cirrhosis

“…Our study reveals that the increase in Pro‐C3 in all patients after TIPS insertion might be due to an increase in collagen type III synthesis associated with deterioration of liver function with changes in liver perfusion after TIPS. This has been shown several times by us and other studies 4, 22, 32, 33. However, the cutoff for survival benefit is much lower than the cutoff for the discrimination of developing acute decompensation in patients receiving TIPS.…”

“…Biochemical parameters as well as portal and systemic hemodynamics were recorded. Blood from the portal and hepatic veins was collected as described 22. The blood sample from the portal vein was taken immediately after puncture of the vein.…”

Gut-Liver Axis Links Portal Hypertension to Acute-on-Chronic Liver Failure

“…On the other hand, ascites formation, induced by PHT, seems to be another pathogenic condition of bacterial translocation. Bacterial translocation is of relevance as it is considered one -if not the most -important trigger of AD and ACLF, as it leads to continuous activation of the immune system and chronic systemic inflammation [14][15][16][17].…”

Gene Polymorphism of Proinflammatory Cytokines (Tnf, Il6) and Their Receptors (Tnfrsf1a, Tnfrsf1b, Il6r): Implications for Non-Alcoholic Fatty Liver Disease

“…Уровень растворимых TNFRI в периферической вене от-ражает тяжесть воспаления в печени при хро-ническом гепатите С [Cubillas et al, 2010], ал-когольном повреждении печени [Naveau et al, 2001] и метаболических расстройствах [Lin et al, 2004]. У пациентов c циррозом содержа-ние этих рецепторов в печеночных венах кор-релирует с портальным выходом эндотоксинов [Trebicka et al, 2011]. В связи с этим уровни растворимых рецепторов TNFRI и TNFRII пред-лагается использовать в клинике как маркеры тяжести заболеваний и прогностические пока-затели [Tokushigе et al, 2007].…”