Endotoxin and the lung: Insight into the host-environment interaction

Singh, Jaspal; Schwartz, David A.

doi:10.1016/j.jaci.2004.11.021

Cited by 45 publications

(46 citation statements)

References 33 publications

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“…The causative mechanism for these observed protective effects remain unclear and require further study, but innate immune responses involving endotoxin-microbial binding receptors, such as Toll-like receptor 4, Toll-like receptor 2, and CD14, might play a key role. 29 Endotoxin, EPS-Pen/Asp, (1/3)-b-D-glucan, and dust were highly correlated, with Pearson correlations ranging from 0.63 to 0.84 (P < .01) and k statistics (a measure of agreement between exposure categories) ranging from 0.22 to 0.59 (P < .05). Therefore firm conclusions as to which specific component or components contributed to the observed effects cannot be drawn.…”

Section: Discussionmentioning

confidence: 98%

Does early indoor microbial exposure reduce the risk of asthma? The Prevention and Incidence of Asthma and Mite Allergy birth cohort study

Douwes

Strien

Doekes

et al. 2006

Journal of Allergy and Clinical Immunology

165

159

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Section: Discussionmentioning

confidence: 98%

Does early indoor microbial exposure reduce the risk of asthma? The Prevention and Incidence of Asthma and Mite Allergy birth cohort study

Douwes

Strien

Doekes

et al. 2006

Journal of Allergy and Clinical Immunology

165

159

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“…Reviews of studies of gene-gene and gene-environment interactions in asthma or atopy susceptibility have been reviewed elsewhere [12][13][14][15][16] and will not be specifically discussed here. Similarly, we will not review the results of genome-wide linkage studies or discuss in detail the six asthma and atopy genes that have been identified by positional cloning, but refer readers to other recent reviews on these topics.…”

Section: Introductionmentioning

confidence: 99%

Asthma genetics 2006: the long and winding road to gene discovery

2006

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Asthma and atopy are complex phenotypes that are influenced by both genetic and environmental factors. A review of nearly 500 papers on disease association studies identified 25 genes that have been associated with an asthma or atopy phenotype in six or more populations. An additional 54 genes have been associated in 2-5 populations. Here, we discuss the methods that have been used to identify susceptibility genes for common diseases and overview the status of asthma genetic research. Finally, current challenges and future directions are discussed.

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“…The airborne microorganisms and their harmful components may not only jeopardize the health status of animals and caretakers inside barns [4,5,6,7], but also pose the risk of spreading disease between barns if pathogenic species are emitted outside [8]. In response to or in anticipation of State or Ffederal legislation on animal welfare, some egg producers are building or planning to build aviary cage-free hen-housing systems.…”

Section: Introductionmentioning

confidence: 99%

Free chlorine loss during spraying of membraneless acidic electrolyzed water and its antimicrobial effect on airborne bacteria from poultry house

Zhao¹,

Xin²,

Zhao³

et al. 2014

Ann Agric Environ Med.

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Spray-application of membraneless acidic electrolyzed water (MLAEW) is a novel technique for disinfection in livestock houses. This study investigated the loss of free chlorine (FC -the major germicidal component in MLAEW) over distance during spraying, as affected by air temperature and initial FC concentration. The antimicrobial effect of MLAEW on airborne bacteria from an aviary laying-hen house was examined. materials and methods. MLAEW was prepared at two FC concentrations: app. 15 and 60 mg L -1 , and sprayed at three air temperatures (18, 25, 32 °C). The original MLAEW solution and MLAEW aerosols collected at 0, 25, and 50 cm from the spray nozzle were analyzed for FC concentrations. Bacteria were immersed into these MLAEW samples and numerated for viable count after 0.5, 2 and 5-min treatments. results. MLAEW aerosols collected at 0 cm lost 11.7-13.2% FC, compared with the original MLAEW solution. This initial loss was affected neither by the initial FC concentration (P = 0.13) nor by air temperature (P = 0.57). The rate of FC loss during travelling was 0.79-0.87 % per cm of aerosol travel distance (% cm -1 ) at 18 °C, 1.08-1.15 % cm -1 at 25 °C, and 1.35-1.49% cm -1 at 32 °C. This travelling loss was affected by air temperature (P = 0.02), but not by initial FC concentration (P = 0.38). Bacteria were completely inactivated at 0.5 min when treated with MLAEW samples with FC > 16.8 mg L -1 , in 2 min when FC > 13.8 mg L -1 , and in 5 min when FC > 7.2 mg L -1 . conclusion. Airborne bacteria from aviary hen house can be effectively inactivated by MLAEW with adequate FC concentration and contact time. During spraying, the anti-microbial efficacy of MLAEW aerosols decreased over distance due to FC loss which exacerbated at higher air temperatures.

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Endotoxin and the lung: Insight into the host-environment interaction

Cited by 45 publications

References 33 publications

Does early indoor microbial exposure reduce the risk of asthma? The Prevention and Incidence of Asthma and Mite Allergy birth cohort study

Does early indoor microbial exposure reduce the risk of asthma? The Prevention and Incidence of Asthma and Mite Allergy birth cohort study

Asthma genetics 2006: the long and winding road to gene discovery

Free chlorine loss during spraying of membraneless acidic electrolyzed water and its antimicrobial effect on airborne bacteria from poultry house

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