Endotoxin- and d-galactosamine-induced liver injury improved by the administration of Lactobacillus, Bifidobacterium and blueberry

Osman, Nadia; Adawi, Diya; Ahrné, Siv; Jeppsson, Bengt; Molin, Göran

doi:10.1016/j.dld.2007.06.001

Cited by 98 publications

(74 citation statements)

References 42 publications

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“…Several researches have reported that probiotics and their fermented products possess antioxidative activities and free radical scavenging properties in vitro and in vivo (Osman et al, 2007;Nurrochmad et al, 2013). In addition, some authors have suggested that mechanism responsible for hepatoprotection by probiotics might be due to the production of polyamines, which are important mediators of cell growth and differentiation and prevent lipid peroxidation in liver microsomes (Kitada et al, 1979;McCormack and Johanson, 1991).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, recent several studies have shown that specific strains of probiotics are effective at inhibiting the liver injury, or hepatic encephalopathy (HE) (Nanji et al, 1994;Kim et al, 2003;Solga, 2003;Zhao et al, 2004;Han et al, 2005a;Osman et al, 2007;Yun et al, 2007;Zedan, 2011;Ou et al, 2012;Wang et al, 2013). In addition, in a previous study, we found B. adolescentis SPM0212 has potential anti-hepatitis B virus activity (Lee et al, 2013).…”

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confidence: 99%

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Hepatoprotective effect of Bifidobacterium adolescentis SPM0212 on carbon tetrachloride induced hepatotoxicity

Lee¹,

Park²,

Kim³

et al. 2015

The Korean Journal of Microbiology

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Probiotics are microbial food supplements or components of bacteria which have traditionally been added to dairy foods for extra health boost. Our aim was to evaluate the hepatoprotective effect of Bifidobacterium adolescentis SPM0212 as probiotics, which we previously found has potential anti-hepatitis B virus activity. The study was conducted using Wistar albino rats and probiotics were treated orally for 9 days consecutively and acute liver injury was induced by administration of carbon tetrachloride (CCl4) on the 7th and 8th days. Liver damage was assessed by quantifying serum activities of glutamate oxaloacetate transaminase (SGOT) and glutamate pyruvate transaminase (SGPT), as well as by histopathological examination. B. adolescentis SPM0212 significantly prevented the elevation of SGOT and SGPT levels, and reduced the negative effect of CCl4 on body and organ weights. Histopathological study revealed the livers of the carbon tetrachloride treated rats showed almost complete loss of normal hepatocyte architecture, but that rats treated with B. adolescentis SPM0212 showed minimal damage and normal hepatocyte architecture. Our results suggest that B. adolescentis SPM0212 be considered useful probiotics for protecting the liver from xenobiotics and hepatitis B virus, and as well as useful as a functional food for maintaining human health.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Hepatoprotective effect of Bifidobacterium adolescentis SPM0212 on carbon tetrachloride induced hepatotoxicity

Lee¹,

Park²,

Kim³

et al. 2015

The Korean Journal of Microbiology

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“…In liver cirrhosis, probiotics have shown positive effects on several parameters including the improvement of liver function, prevention of infection, improvement of the hyperdynamic circulation and prevention of hepatic encephalopathy (Liu et al, 2004). Beneficial effects of probiotics have been reported in an animal model of alcohol-induced liver injury (Nanji et al, 1994) and of LPS-induced liver injury (Ewaschuk et al, 2007;Osman et al, 2007). Patients with alcoholic liver cirrhosis treated with Lactobacillus casei Shirota three times daily for 4 weeks showed restoration of deranged neutrophil phagocytic capacity, compared to controls (Stadlbauer et al, 2008).…”

Section: Modulation Of Innate Immunity In the Treatment Of Aldmentioning

confidence: 99%

Innate Immunity in Alcohol Liver Disease

Soares¹,

Pimentel‐Nunes²

2012

Trends in Alcoholic Liver Disease Research - Clinical and Scientific Aspects

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“…Probiotics and their products have antioxidant activities and free-radical scavenging properties in vitro and in vivo. [23,24] For example, LcZ (L. casei Zhang) may be related to down-regulation of toll-like receptor 4 (TLR4), which may cause inhibition of oxidative stress and tumour necrosis factor alpha (TNF-a). In addition, probiotic products are important mediators of cell growth and differentiation and prevent lipid peroxidation in liver microsomes.…”

Section: Parametersmentioning

confidence: 99%

Hepatoprotective effects of dual-coated and uncoated mixture of probiotics in rats

Park

Lee

Kim

et al. 2015

Biotechnology & Biotechnological Equipment

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Probiotics have been used for the treatment of various disorders or as alternative therapies. The stability of dual-coated probiotics is increased in the gastrointestinal environment. The aim of the present study was to evaluate the hepatoprotective effects of dual-coated and uncoated probiotic supplements, following liver injury. Albino Wistar rats were orally treated with probiotics daily and carbon tetrachloride (CCl 4 ) was administered on the seventh and eighth days to induce acute liver damage. Hepatoprotective effects were determined by assessment of serum glutamicÀoxaloacetic transaminase (SGOT) and serum glutamicÀpyruvic transaminase (SGPT) activities, as well as by histopathological examination. The CCl 4 -treated control group showed increased SGOT and SGPT activities as compared with the normal control group. However, treatment with probiotics reduced SGOT and SGPT activities, following CCl 4 administration. Animals treated with probiotics showed reduced liver weight than that in the standard CCl 4 group which did not receive probiotics. Histopathological analysis showed that administration of probiotics minimized liver damage by reducing the level of morphological changes and necrosis. Therefore, probiotics may be effective hepatoprotective agents and should be considered useful for the treatment and prevention of hepatic disorders.

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Endotoxin- and d-galactosamine-induced liver injury improved by the administration of Lactobacillus, Bifidobacterium and blueberry

Cited by 98 publications

References 42 publications

Hepatoprotective effect of Bifidobacterium adolescentis SPM0212 on carbon tetrachloride induced hepatotoxicity

Hepatoprotective effect of Bifidobacterium adolescentis SPM0212 on carbon tetrachloride induced hepatotoxicity

Innate Immunity in Alcohol Liver Disease

Hepatoprotective effects of dual-coated and uncoated mixture of probiotics in rats

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