Endothelium in aneurysmal bone cyst

Abstract

The surface of the large cystic spaces and dilated blood vessels in seven cases of aneurysmal bone cysts was studied. The endothelium of the blood vessels was surrounded by a layer of collagen types IV and V, and the endothelial cells contained factor VIII related antigen demonstrated by the peroxidase anti-peroxidase technique. Some blood vessels were dilated resembling small aneurysmal spaces. The visible surfaces of the aneurysmal spaces were devoid of collagen types IV and V, and of factor VIII related antigen. Ultrastructural analysis of paraffin embedded sections did not show the characteristic fine structural features of endothelium covering the aneurysmal spaces. It is concluded that the large spaces in aneurysmal bone cysts are devoid of basement membranes and endothelial cells. The absence of endothelium may explain the abundance of haemorrhages in these lesions. Immunocytochemical demonstration of endothelial antigen provides a valuable tool for the differential diagnosis between aneurysmal bone cysts and vascular tumours.

Aneurysmal Bone Cysts Express Vascular Markers

“…The difference between our findings and those reported in older studies [14,15] could be due to methodology, including use of antigen retrieval prominently stains cavity border and septal blood vessels. B. VEGF-C continuously stains the cavity border, C GLUT-1 stains the cavity border and some septal vessels.…”

“…Sometimes in addition to capillaries, larger vessels possibly representing feeder vessels are seen in the septa of ABCs [1]. Results of immunohistochemical studies using a limited number of vascular markers support a vascular lining of the cavities [13][14][15][16], but endothelium has not been identified by ultrastructural examination [13,[15][16][17][18].…”

Aneurysmal Bone Cyst: A Review of 150 Patients

“…[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Examination of the tissue at the time of surgery has, in the past, demonstrated a blood-filled cavity within an expanded region of the bone, and the cells that line the cyst wall show fibrous components, macrophages, giant cells, and islands of bone. The lesion was first described by Jaffe and Lichtenstein 1 in 1942, was subsequently further defined by both of these authors, 2,3 and became known as Jaffe-Lichtenstein disease.…”

Aneurysmal Bone Cyst on the Carpus of an African Collared Dove (Streptopelia roseogrisea)

“…This criterion is useful to differentiate them from vascular tumors. 5 Aneurysmal bone cysts are benign and nonneoplastic, and, although they may be associated with locally aggressive growth, metastasis does not occur. 6,7 However, if left untreated, they may destroy a large part of the bone in which they originate and may also compress surrounding soft tissue and adjacent bone.…”

“…6,7 However, if left untreated, they may destroy a large part of the bone in which they originate and may also compress surrounding soft tissue and adjacent bone. 5,6 Aneurysmal bone cysts have been reported in humans, 7,8 dogs, [9][10][11][12][13][14] cats, 6 horses, 4 cows, 15 and psittacine birds. 2 To the best of our knowledge, this is the first report of an aneurysmal bone cyst in a columbiform bird.…”