Endothelium-dependent vasodilation is related to the fatty acid composition of serum lipids in healthy subjects

Sarabi, Mahziar; Vessby, Bengt; Millgård, Jonas; Lind, Lars

doi:10.1016/s0021-9150(00)00658-4

Cited by 62 publications

(54 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We observed that palmitoleic acid reduced the production of cytokines and chemokines (IL-6, IL-8, MCP-1) and the cell-surface content of ICAM-1 Intercellular Adhesion Molecule in endothelial cells stimulated with TNF-α (Souza et al, in press) ( Figure 2). Consistent with these observations, a positive correlation of serum palmitoleic acid levels and endothelial function was observed in healthy subjects [92] and in patients with high cardiometabolic risk. [64] Recently, it was observed that palmitoleic acid treatment decreased atherosclerotic lesion formation in the aorta of ApoE −/− mice (atherosclerosis murine model) on a hypercholesterolemic diet, reducing foam cell plaques and necrotic areas by preventing the inflammasome activation [12] (Table 5).…”

Section: Atherosclerosissupporting

confidence: 81%

Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?

Souza

Vannice²,

Neto

et al. 2017

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Although dietary fatty acids can modulate metabolic and immune responses, the effects of palmitoleic acid (16:1n-7) remain unclear. Since this monounsaturated fatty acid is described as a lipokine, studies with cell culture and rodent models have suggested it enhances whole body insulin sensitivity, stimulates insulin secretion by β cells, increases hepatic fatty acid oxidation, improves the blood lipid profile, and alters macrophage differentiation. However, human studies report elevated blood levels of palmitoleic acid in people with obesity and metabolic syndrome. These findings might be reflection of the level or activity of stearoyl-CoA desaturase-1, which synthesizes palmitoleate and is enhanced in liver and adipose tissue of obese patients. The aim of this review is to describe the immune-metabolic effects of palmitoleic acid observed in cell culture, animal models, and humans to answer the question of whether palmitoleic acid is a plausible nonpharmacological strategy to prevent, control, or ameliorate chronic metabolic and inflammatory disorders. Despite the beneficial effects observed in cell culture and in animal studies, there are insufficient human intervention studies to fully understand the physiological effects of palmitoleic acid. Therefore, more human-based research is needed to identify whether palmitoleic acid meets the promising therapeutic potential suggested by the preclinical research.

show abstract

Section: Atherosclerosissupporting

confidence: 81%

Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?

Souza

Vannice²,

Neto

et al. 2017

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…We have previously used the en-dothelial function index in a number of studies and found it to be correlated to the main cardiovascular risk factors, such as blood pressure, 21 smoking, 22 HDL-cholesterol, 23 and a highfat diet. 24 This index has also been used by others who found a correlation with the major risk factors.…”

Section: Discussionmentioning

confidence: 99%

Impaired Endothelial Function of Forearm Resistance Arteries in CADASIL Patients

Stenborg

Kalimo

Viitanen

et al. 2007

Stroke

View full text Add to dashboard Cite

Background and Purpose-Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary arteriopathy, which mainly involves the brain causing stroke and dementia. Mice expressing the mutated protein display early dysfunction in vasoreactivity in resistance arteries, but studies of patients have been inconclusive so far. Methods-We examined peripheral endothelium-dependent vasodilatation in 10 CADASIL-patients and 20 controls using 3 methods: venous occlusion plethysmography of forearm blood flow with intraarterial acetylcholine and sodium nitroprusside infusions for evaluation of resistance arteries, ultrasound with flow mediated vasodilatation (FMD) of the brachial artery for evaluation of a conduit artery, and the pulse wave method with measurements before and after terbutaline for evaluation of systemic endothelium-dependent vasodilation. Results-The CADASIL patients displayed reductions in both basal (Pϭ0.034) and stimulated blood flow (Pϭ0.023 for the highest dose of acetylcholine) and an impaired endothelium-dependent vasodilation when investigated in forearm resistance arteries (Pϭ0.019). The FMD and the pulse wave method did not show any reduction in endotheliumdependent vasodilation in the patients. Conclusions-Endothelium-dependent vasodilation was impaired in resistance arteries, but not in a conduit artery, in the forearm of CADASIL patients.

show abstract

“…31 An unfavorable serum CE fatty acid profile with a high proportion of saturated fatty acids and a low proportion of linoleic acid has previously been shown to predict LVH over 20 years, 23 indicating that the fatty acid pattern is an important long-term determinant of LVH. Endothelial dysfunction is associated with LVH, 32 and because endothelium-dependent vasodilation is related to fatty acid composition of serum CEs, 33 this may represent a possible link between the fatty acid profile, sustained hypertension, and LVH.…”

Section: Discussionmentioning

confidence: 99%

Different Metabolic Predictors of White-Coat and Sustained Hypertension Over a 20-Year Follow-Up Period

et al. 2002

View full text Add to dashboard Cite

Background-The clinical significance of white-coat hypertension is still unclear. Moreover, no study has examined metabolic predictors of white-coat versus sustained hypertension. Methods and Results-We investigated men (nϭ602) in a longitudinal population-based cohort who at age 70 years were identified as normotensive, white-coat hypertensive (office blood pressure [BP] Ն140/90 and daytime ambulatory BP Ͻ135/85 mm Hg), and sustained hypertensive (office BP Ն140/90 and daytime ambulatory BP Ն135/85 mm Hg). At baseline, when the subjects were aged 50 years, blood glucose, insulin, lipids, and fatty acid composition of the serum cholesterol esters were analyzed. The investigations at age 70 years included determination of insulin sensitivity and target organ damage. At age 50 years, individuals who 20 years later were identified as white-coat hypertensive or sustained hypertensive showed significantly elevated BP, heart rate, and impaired glucose tolerance compared with normotensive subjects but white coat hypertensive subjects were leaner and had a more favorable serum cholesterol ester fatty acid profile than did sustained hypertensive subjects. At age 70 years, both white-coat and sustained hypertensive subjects showed an impaired insulin sensitivity, elevated blood glucose, and increased serum insulin and heart rate compared with normotensive subjects, but left ventricular mass and urinary albumin excretion were increased only in sustained hypertensive subjects. Conclusions-These findings indicate that although metabolic abnormalities and elevated heart rate were consistent over time in both hypertensive groups, a lower body mass index and more favorable dietary fat composition predicted the development of white-coat as opposed to sustained hypertension over 20 years. (Circulation. 2002;106:63-68.)

show abstract

Endothelium-dependent vasodilation is related to the fatty acid composition of serum lipids in healthy subjects

Cited by 62 publications

References 36 publications

Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?

Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?

Impaired Endothelial Function of Forearm Resistance Arteries in CADASIL Patients

Different Metabolic Predictors of White-Coat and Sustained Hypertension Over a 20-Year Follow-Up Period

Contact Info

Product

Resources

About