Endothelium-dependent induction of vasorelaxation by Melissa officinalis L. ssp. officinalis in rat isolated thoracic aorta

Ersoy, Süleyman; Orhan, İlkay Erdoğan; Turan, Nilüfer N.; Şahan, G.; Ark, Mustafa; Tosun, Fâtma

doi:10.1016/j.phymed.2008.05.007

Cited by 42 publications

(26 citation statements)

References 24 publications

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“…The principle quantitative components of polyphenols isolated from SF are: hydroxycinnamic acid derivatives: rosmarinic acid (caffeic acid dimer), salvianolic acids (caffeic acid polymers), caffeic acid phenethyl ester (caffeic acid derivative); phenolic diterpenes: carnosic acid and carnosol; and flavonoids: luteolin-7-O-glucoside and rutin 37, 38 . In framework of the present study, rosmarinic acid exerts an arterio-relaxant effect in rat isolated thoracic aorta 39 . Moreover, rosmarinic acid was reported to lower BP in fructose-fed hypertensive rats.…”

Section: Introductionmentioning

confidence: 80%

Salvia fruticosa Induces Vasorelaxation In Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway

Anwar

Samaha

Ballan

et al. 2017

Sci Rep

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Salvia fruticosa (SF) Mill. is traditionally used for its antihypertensive actions. However, little is known about its pharmacologic and molecular mechanisms of action. Here we determined the effects of an ethanolic extract of SF leaves on rings of isolated thoracic aorta from Sprague-Dawley rats. Our results show that SF extract increased nitric oxide production and relaxed endothelium-intact rings in a dose-dependent (0.3 µg/ml–1 mg/ml) manner, and the maximum arterial relaxation (Rmax) was significantly reduced with endothelium denudation. Pretreatment of endothelium-intact rings with L-NAME (a non-selective inhibitor of nitric oxide synthase, 100 µM), or ODQ (an inhibitor of soluble guanylyl cyclase, 10 µM) significantly diminished SF-mediated vasorelaxation. Furthermore, SF induced Akt phosphorylation as well as increased cGMP levels in rings treated with increasing doses of SF. Prior exposure to PI3K inhibitors, wortmannin (0.1 µM) or LY294002 (10 µM), decreased cGMP accumulation and attenuated the SF-induced vasorelaxation by approximately 50% (Rmax). SF-evoked relaxation was not affected by indomethacin, verapamil, glibenclamide, tetraethylammonium, pyrilamine or atropine. Taken together, our results indicate that SF induces endothelium-dependent vasorelaxation through the PI3K/Akt/eNOS/NO/sGC/cGMP signaling pathway. Our data illustrate the health-orientated benefits of consuming SF which may act as an antihypertensive agent to reduce the burden of cardiovascular complications.

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Section: Introductionmentioning

confidence: 80%

Salvia fruticosa Induces Vasorelaxation In Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway

Anwar

Samaha

Ballan

et al. 2017

Sci Rep

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“…Winter savory extract (which was obtained from winter savory by hot-water extraction and lyophilization) contains various polyphenols other than volatiles (Darbour et al, 1996;Ćetković et al, 2007;Gião et al, 2009;Silva et al, 2009). Among these polyphenols, rosmarinic acid has been found to improve endothelium-dependent vasodilation by the action of nitric oxide based on an in vitro study (Ersoy et al, 2008). In addition, other polyphenolic components in winter savory (e.g., naringenin, eriodictyol, luteolin) have been reported to induce vasodilation based on an in vitro study using rat aortae (Sán-chez de Rojas et al, 1996a;Sánchez de Rojas et al, 1996b;Sánchez de Rojas et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Effects of Carvacrol and Volatile Fraction of Winter Savory (Satureja montana L.) on Body Temperature in Humans Who Experience Cold Sensitivity

Masuda¹,

Mori²,

Matsui³

et al. 2013

FSTR

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Ingestion of winter savory extract has been reported to inhibit the decrease in peripheral body temperature in people who experience cold sensitivity. However, the active ingredients underlying this effect are not known. We sought to elucidate the effects of the volatile components of winter savory on body temperature. Carvacrol (the main volatile component and a transient receptor potential channel ankyrin 1 (TRPA1) agonist in winter savory) increased core body temperature, but did not inhibit the decrease in peripheral body temperature after ingestion. In addition, the volatile fraction of winter savory (which contained various components in addition to carvacrol) induced not only an increase in core body temperature, but also inhibited the decrease in peripheral body temperature. These results suggest that the volatile components in winter savory may be effective for alleviating cold sensitivity, and that carvacrol is one of the active ingredients in winter savory.

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“…Spices of the Laminaceae family are known to have a high antioxidant capacity compared to many other spices (Baño et al, 2003;Fecka and Turek, 2007;Exarchou et al, 2002;Fujie et al, 2003). Rosmarinic acid, a common polyphenol antioxidant component of the Laminaceae family, is found to improve endothelium-dependent vasodilation by the action of NO in vitro (Grande, et al, 2004;Ersoy et al, 2008). To examine the contribution of rosmarinic acid to the warming effect on the peripheral body temperature, we investigated the warming effect of powder of the boiled-water extract of other spices in the Laminaceae family, i.e., oregano and sweet majoram, which contain rosmarinic acid content similar to WSE, as described in the results.…”

Section: Discussionmentioning

confidence: 99%

Effects of Winter Savory (Satureja montana L.) on Peripheral Body Temperature of People Who Experience a 'Feeling of Cold' (Hie-Sho)

Masuda¹,

Mori²,

Hirooka³

et al. 2011

FSTR

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The objective of this study was to evaluate the effect of winter savory (Satureja montana L.) on the peripheral body temperature of people who experience a 'feeling of cold' (hie-sho). We conducted a clinical trial with a double-blind, randomized, placebo-controlled, single-ingestion crossover design. First, under cold-water loading conditions, the ingestion of powdered winter savory extract (WSE) was found to accelerate the recovery rate of the medial middle-finger temperature. Next, under daily living conditions, the peripheral temperature of the wrist, medial and dorsal middle finger, and middle toe after WSE ingestion was found to be higher than that after the placebo ingestion. In addition, the blood flow and thermal sensation data agreed with the changes in the peripheral body temperature observed by WSE ingestion. This is the first report to demonstrate that WSE ingestion has a warming effect on the peripheral body temperature of people who experience a 'feeling of cold'.Keywords: winter savory, peripheral body temperature, feeling of cold, human, warming, thermoception *To whom correspondence should be addressed. E-mail: masuda.hideki@ogawa.net IntroductionThe 'feeling of cold' (hie-sho) occurs at epidemic proportions among Japanese women and causes a variety of troubling symptoms. These symptoms include: shoulder stiffness, headache, swelling, sleeplessness, frequent urination, peripheral numbness, limb pain, chilblains, and purple fingernails (Miura et al., 2001;Yamato and Aomine, 2002). These symptoms are not limited to menopausal women, as they are also observed in young women (Miyamoto et al., 1995); therefore, it is worth studying methods of alleviating these symptoms.The feeling of cold is thought to be caused by sympathetic hypertonia, which causes disturbances in peripheral circulation induced by contraction of peripheral vessels (Takatori et al., 1990;Ushiroyama, 2005). Therefore, improving peripheral circulation is important for alleviating the symptoms of feeling of cold.Endothelial nitric oxide (NO), which is synthesized by the activation of nitric oxide synthase (NOS), was reported to participate in locally mediated vasodilation, followed by an increase in peripheral skin temperature (Kellogg et al., 1999 and. The activity of NOS is affected by dietary factors (Wu and Meininger, 2002), and a variety of polyphenolic compounds have been demonstrated to induce the activation of NOS (Grande et al., 2004;Duarte et al., 1993;Herrera et al., 1996;Andriambeloson et al., 1998;Flesch et al., 1998;Burns et al., 2000;Karim et al., 2000;Mullen et al., 2002; Pérez-Vizcaíno et al., 2002). Therefore, the ingestion of these compounds might improve peripheral circulation, followed by alleviation of the symptoms of feeling of cold.Winter savory (Satureja montana L.), which belongs to the Laminaceae family and has been used as a food condiment for hundreds of years, contains a variety of active components, such as essential oil (Piccaglia and Marotti, 1993;Grosso et al., 2010) and phenolic compounds (Tomás-Ba...

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Endothelium-dependent induction of vasorelaxation by Melissa officinalis L. ssp. officinalis in rat isolated thoracic aorta

Cited by 42 publications

References 24 publications

Salvia fruticosa Induces Vasorelaxation In Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway

Salvia fruticosa Induces Vasorelaxation In Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway

Effects of Carvacrol and Volatile Fraction of Winter Savory (Satureja montana L.) on Body Temperature in Humans Who Experience Cold Sensitivity

Effects of Winter Savory (Satureja montana L.) on Peripheral Body Temperature of People Who Experience a 'Feeling of Cold' (Hie-Sho)

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