Endothelium-dependent hypotensive and vasorelaxant effects of the essential oil from aerial parts of Mentha x villosa in rats

Guedes, Diego Nunes; Silva, D.F.; Barbosa-Filho, José Maria; Medeiros, Isac A.

doi:10.1016/j.phymed.2004.04.002

Cited by 42 publications

(11 citation statements)

References 30 publications

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“…Essential oil and its aroma volatile constituents have shown an antioxidant activity against LDL oxidation (Grassmann et al, 2005) and hypotensive effect which play an important role in myocardial protection. The hypotensive effect induced by the oil is probably due to its direct cardiodepressant action and peripheral vasodilation, which can be attributed to both endothelium-dependent and endotheliumindependent mechanisms (Nunes Guedes et al, 2004). Due to the similar aromatic chemical composition that different essential oils may have, these may be related to the cardioprotective effect SPEO showed in this study.…”

Section: Groupmentioning

confidence: 58%

Effect of essential oil of Syringa pinnatifolia Hemsl. var. alashanensis on ischemia of myocardium, hypoxia and platelet aggregation

Yan

Wuliji

Zhao

et al. 2010

Journal of Ethnopharmacology

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Section: Groupmentioning

confidence: 58%

Effect of essential oil of Syringa pinnatifolia Hemsl. var. alashanensis on ischemia of myocardium, hypoxia and platelet aggregation

Yan

Wuliji

Zhao

et al. 2010

Journal of Ethnopharmacology

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“…Assuming that RA (and its associated metabolites) is not the primary bioactive phytochemical, a good candidate for future investigation may be the flavonoid fraction of HRAM. Flavonoids are stable phenolic compounds found abundantly in plants including Mentha spicata [25], and have reported modulatory effect on NO formation [28] and NO scavenging [26,27]. While the stability of some flavonoids in the presence of intestinal enzymes has been questioned [29], the flavonoid fraction of HRAM is never-the-less a logical place to continue the search for a primary bioactivity phytochemical in HRAM.…”

Section: Discussionmentioning

confidence: 99%

Protection against LPS-induced cartilage inflammation and degradation provided by a biological extract of Mentha spicata

Pearson

Fletcher

Kott

et al. 2010

BMC Complement Altern Med

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BackgroundA variety of mint [Mentha spicata] has been bred which over-expresses Rosmarinic acid (RA) by approximately 20-fold. RA has demonstrated significant anti-inflammatory activity in vitro and in small rodents; thus it was hypothesized that this plant would demonstrate significant anti-inflammatory activity in vitro. The objectives of this study were: a) to develop an in vitro extraction procedure which mimics digestion and hepatic metabolism, b) to compare anti-inflammatory properties of High-Rosmarinic-Acid Mentha spicata (HRAM) with wild-type control M. spicata (CM), and c) to quantify the relative contributions of RA and three of its hepatic metabolites [ferulic acid (FA), caffeic acid (CA), coumaric acid (CO)] to anti-inflammatory activity of HRAM.MethodsHRAM and CM were incubated in simulated gastric and intestinal fluid, liver microsomes (from male rat) and NADPH. Concentrations of RA, CA, CO, and FA in simulated digest of HRAM (HRAMsim) and CM (CMsim) were determined (HPLC) and compared with concentrations in aqueous extracts of HRAM and CM. Cartilage explants (porcine) were cultured with LPS (0 or 3 μg/mL) and test article [HRAMsim (0, 8, 40, 80, 240, or 400 μg/mL), or CMsim (0, 1, 5 or 10 mg/mL), or RA (0.640 μg/mL), or CA (0.384 μg/mL), or CO (0.057 μg/mL) or FA (0.038 μg/mL)] for 96 h. Media samples were analyzed for prostaglandin E2 (PGE2), interleukin 1β (IL-1), glycosaminoglycan (GAG), nitric oxide (NO) and cell viability (differential live-dead cell staining).ResultsRA concentration of HRAMsim and CMsim was 49.3 and 0.4 μg/mL, respectively. CA, FA and CO were identified in HRAMsim but not in aqueous extract of HRAM. HRAMsim (≥ 8 μg/mL) inhibited LPS-induced PGE2 and NO; HRAMsim (≥ 80 μg/mL) inhibited LPS-induced GAG release. RA inhibited LPS-induced GAG release. No anti-inflammatory or chondroprotective effects of RA metabolites on cartilage explants were identified.ConclusionsOur biological extraction procedure produces a substance which is similar in composition to post-hepatic products. HRAMsim is an effective inhibitor of LPS-induced inflammation in cartilage explants, and effects are primarily independent of RA. Further research is needed to identify bioactive phytochemical(s) in HRAMsim.

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“…There have been observations for its beneficial effects in common cold, fever, sinusitis, cough, bronchitis, intestinal colic, indigestion, nausea and vomiting, anorexia, and menstrual disturbances (Mokaberinejad et al, 2012). In addition, several previous works have reported smooth muscle relaxing and calcium channel blocking activities of M. longifolia (Guedes, Silva, Barbosa-Filho, & de Medeiros, 2004).…”

mentioning

confidence: 99%

Mentha longifolia alleviates experimentally induced angina via decreasing cardiac load

2018

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Angina occurs due to imbalance between heart oxygen demand and supply and is associated with serious morbidity and mortality. Here, the possible antianginal effect of Mentha longifolia extract was studied in experimental model of angina. Aerial parts of M. longifolia were extracted, standardized, and given to rats three days before angina. Heart hemodynamics and conductivity were recorded by microtip catheter and surface electrodes. M. longifolia extract significantly alleviated the sustained decline in cardiac contractility after vasopressin exposure. However, M. longifolia did not affect the impaired cardiac dilation after vasopressin. Heart rate was significantly decreased after vasopressin exposure in rats treated with M. longifolia compared with untreated animals. In addition, M. longifolia produced more increase in systolic and diastolic durations after vasopressin exposure compared with untreated animals. Moreover, the plant extract alleviated the ST height changes during vasopressin injection. M. longifolia extract alleviates impaired cardiac function associated with angina through decreasing heart work. Practical applications The present study is the first to study the effect of M. longifolia in an experimental model of angina. M. longifolia alleviated the impaired cardiac contractility associated with angina exposure. The antianginal effect of M. longifolia could be through reducing cardiac load. This can be concluded from the decrease in heart rate and the systolic and diastolic cycles elongation after exposure to vasopressin in animals pretreated with M. longifolia. This helps in reducing the associated cardiac ischemia upon exposure to vasopressin as indicated by ST change. This could provide new directions in the management of the serious angina disease.

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Endothelium-dependent hypotensive and vasorelaxant effects of the essential oil from aerial parts of Mentha x villosa in rats

Cited by 42 publications

References 30 publications

Effect of essential oil of Syringa pinnatifolia Hemsl. var. alashanensis on ischemia of myocardium, hypoxia and platelet aggregation

Effect of essential oil of Syringa pinnatifolia Hemsl. var. alashanensis on ischemia of myocardium, hypoxia and platelet aggregation

Protection against LPS-induced cartilage inflammation and degradation provided by a biological extract of Mentha spicata

Mentha longifolia alleviates experimentally induced angina via decreasing cardiac load

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