Endothelium-Dependent Forearm Vasodilation Is Reduced in Normotensive Subjects with Familial History of Hypertension

Taddei, Stefano; Virdis, Agostino; Mattei, Paola; Arzilli, F; Salvetti, Antonio

doi:10.1097/00005344-199204002-00054

Cited by 104 publications

(52 citation statements)

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“…8,9 In fact, studies in offspring and relative of hypertensive patients suggest that IEDD may precede the development of HBP. 10,11 Systemic inflammation is a state that involves many pathophysiological processes and several inflammatory markers have been used to measure CMI. Epidemiologic data support the existence of an association between different inflammatory markers and HBP.…”

Section: Epidemiologic Evidencementioning

confidence: 99%

“…44 Moreover, TNF-a plays a fundamental role in inducing IEDD, 37 a condition that seems to play a role in the pathogenesis of essential hypertension and that is also present in offspring of hypertensive patients. 11,10 Some studies in human subjects (Table 3) have shown a positive association between TNF-a level and HBP, 16,33,34 while others have not. 27,29 However, these studies have failed to control for other risk factors for HBP.…”

Section: Epidemiologic Evidencementioning

confidence: 99%

“…The reduced IEDD of small and large vessel observed in normotensive offspring and relative of HBP patients 10,11,72 suggests that a defect on the NO pathway precedes the onset of HBP. Unfortunately, it is not known whether inflammatory markers are also elevated in normotensive relatives of hypertensive patients.…”

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confidence: 99%

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Inflammation, endothelial dysfunction, and the risk of high blood pressure: epidemiologic and biological evidence

2003

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Section: Epidemiologic Evidencementioning

confidence: 99%

Section: Epidemiologic Evidencementioning

confidence: 99%

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Inflammation, endothelial dysfunction, and the risk of high blood pressure: epidemiologic and biological evidence

2003

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“…58,60 Normotensive offspring of hypertensive parents exhibit impaired endothelium-dependent vasodilation to acetylcholine. 61 In parallel to manifest hypertension, in normotensive offspring, vasoconstriction due to inhibition of NO synthesis is decreased. 62 Thus, derangement of endothelial function in hypertension is likely to be caused in part by genetic factors, and not just a consequence of elevated blood pressure (although the haemodynamic factor is an important contributor).…”

Section: Nitric Oxide In Human Hypertensionmentioning

confidence: 99%

Working under pressure: the vascular endothelium in arterial hypertension

et al. 2000

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The vascular endothelium synthesizes and releases a spectrum of vasoactive substances like nitric oxide (NO) and endothelin (ET). In hypertension, the delicate balance of endothelium-derived factors is disturbed. ET acts as the natural counterpart to endothelium-derived NO, which exerts vasodilating, antithrombotic, and antiproliferative effects, and inhibits leukocyte-adhesion to the vascular wall. Besides its blood pressure rising effect also in man, ET induces vascular and myocardial hypertrophy, which are independent risk factors for cardiovascular morbidity and mortality. The derangement of endothelial function in hypertension is likely to be caused in part by genetic factors, but also due to elevated blood pressure itself. Due to its position between blood pressure and smooth muscle cells responsible for peripheral resistance, the endothelium is thought to be both target and mediator of arterial hypertension. Oxi-

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“…5,6 Endothelial dysfunction was known to be associated with atherosclerosis, systemic hypertension, and congestive heart failure. [7][8][9] Since the noninvasive measurement of endothelial function with ultrasound was established by Celermajer et al, 10 endothelial function has been evaluated for prognosis and response to treatment as an independent predictor of future cardiovascular events. 11,12 Thus, we designed the study to evaluate endothelial function in patients with exaggerated blood pressure response during treadmill tests.…”

Section: Introductionmentioning

confidence: 99%

Endothelial dysfunction in patients with exaggerated blood pressure response during treadmill test

Chang

Chung

Choi

et al. 2004

Clinical Cardiology

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SummaryBackground: The diagnostic and prognostic importance of exaggerated blood pressure response to exercise is controversial. Endothelial dysfunction has been demonstrated in patients with atherosclerosis and risk factors for coronary artery disease, but there is a paucity of information on patients with exercise-induced hypertension.Hypothesis: We designed the study to evaluate endothelial function in patients with exaggerated blood pressure response during exercise.Methods: Exercise-induced hypertension was defined as systolic blood pressure ≥ 210 mmHg in men and ≥ 190 mmHg in women during the treadmill test. Using a high-resolution ultrasound technique, endothelial function of the brachial artery in patients with exercise-induced hypertension (n = 25) and control subjects (n = 25) was investigated.Results: Endothelium-dependent vasodilation was impaired in patients with exercise-induced hypertension compared with controls (7.77 ± 5.14 vs. 2.81 ± 2.29%, p < 0.05). On univariate analysis, the extent of vasodilation correlated negatively with age (r = Ϫ0.43, p < 0.05) and ∆ systolic blood pressure (r = Ϫ0.39, p < 0.05). Even after adjustment for factors known to affect endothelial function, endothelium-dependent vasodila-

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Endothelium-Dependent Forearm Vasodilation Is Reduced in Normotensive Subjects with Familial History of Hypertension

Cited by 104 publications

References 0 publications

Inflammation, endothelial dysfunction, and the risk of high blood pressure: epidemiologic and biological evidence

Inflammation, endothelial dysfunction, and the risk of high blood pressure: epidemiologic and biological evidence

Working under pressure: the vascular endothelium in arterial hypertension

Endothelial dysfunction in patients with exaggerated blood pressure response during treadmill test

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