Endothelium

Boulanger, Chantal M.

doi:10.1161/atvbaha.116.306940

Cited by 71 publications

(66 citation statements)

References 61 publications

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“…VEGFR1 is essential for survival by negatively regulating the levels of endogenous vascular endothelial growth factor (VEGF). Internalization and signaling of functional VEGF receptors will enhance angiogenic growth of blood vessels 24 . Sustaining angiogenesis is necessary for circulation and anti-angiogenic treatment causes cardiovascular morbidity 25 .…”

Section: Discussionmentioning

confidence: 99%

Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population

et al. 2017

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Preeclampsia is a common pregnancy-specific vascular disorder characterized by new-onset hypertension and proteinuria during the second half of pregnancy. The etiology of the disease is unknown but predisposition to preeclampsia is in part heritable. Preeclampsia is associated with an increased risk of cardiovascular disease later in life. We have sequenced 124 candidate genes implicated in preeclampsia to pinpoint genetic variants contributing to predisposition to or protection from preeclampsia. First, targeted exomic sequencing was carried out in 500 preeclamptic women and 190 controls from the Finnish Genetics of Preeclampsia Consortium (FINNPEC) cohort. Then 122 women with a history of preeclampsia and 1,905 parous women with no such history from the National FINRISK Study were included in the analyses. We tested 146 rare and low-frequency variants and found an excess (observed 13 versus expected 7.3) nominally associated with preeclampsia (p< 0.05). The most significantly associated sequence variants were protective variants rs35832528 (E982A; p=2.49E-4, OR=0.387) and rs141440705 (R54S; p=0.003, OR=0.442) in Fms Related Tyrosine Kinase 1 (FLT1). These variants are enriched in the Finnish population with minor allele frequencies 0.026 and 0.017, respectively. They may also be associated with a lower risk of heart failure in 11,257 FINRISK women. This study provides the first evidence of maternal protective genetic variants in preeclampsia.

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Section: Discussionmentioning

confidence: 99%

Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population

et al. 2017

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“…Vascular endothelial cells form a lining on the interior surface of blood vessels and play important roles in thrombosis, vascular permeability, and inflammation (Boulanger, 2016). Endothelial cell–cell adhesion is essential for normal endothelial barrier function and immune responses (Dejana and Orsenigo, 2013; Gavard, 2014).…”

Section: Introductionmentioning

confidence: 99%

The VE-cadherin cytoplasmic domain undergoes proteolytic processing during endocytosis

Kowalczyk

2017

MBoC

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“…Similarly, these alterations may cause endothelial dysfunction and vascular damage, later leading to clinical CVD events. 84,90,125,126 Although the mechanism of hypoxia is not known in RLS/PLMS, proposed hypotheses include altered microcirculation/reduced blood flow, or altered iron metabolism compromising oxygen uptake to peripheral tissues. However, more data are needed to evaluate these possibilities.…”

Section: Perspectives Of Rls/plms and Cardiovascular Diseasementioning

confidence: 99%

Cardiovascular comorbidity in patients with restless legs syndrome: current perspectives

Vargas-Pérez¹,

Bagai²,

Walters³

2017

JPRLS

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Endothelium

Cited by 71 publications

References 61 publications

Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population

Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population

The VE-cadherin cytoplasmic domain undergoes proteolytic processing during endocytosis

Cardiovascular comorbidity in patients with restless legs syndrome: current perspectives

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