Endothelioprotective Impact of 2-Ethyl-3-Hydroxy-6-Methylpyridine Nicotinate

Abstract

A main issue in pharmacology is the seek for effective agents for the correction of ED. To study the endothelioprotective effects of 2-ethyl-3-hydroxy-6-methylpyridinium (2e3h6m) nicotinate under conditions of L-NAME-induced oxidation. The L-NAME pattern of induced oxide efficiency (25 mg/g) for one week was used. The endothelial and cardioprotective effect of 2e3h6m nicotinate at an amount of 3.75 mg/kg compared to picamilon 10 mg/kg was examined via the coefficient of ED (QED) and a number of exercise tests. Nicotinate 2e3h6m and picamilon exerted a pronounced endothelioprotective impact on the pattern of L-NAME-induced NO deficiency, which manifested itself in a decrease in the coefficient of endothelial dysfunction (ED). At the same time, 2e3h6m nicotinate (7.6 mg/kg) was 2.1 times more effective than picamilon (10 mg/kg). So, 2e3h6m nicotinate was produced itself as an endothelio and cardioprotector.

Method for obtaining supramolecular complex based on 3-ohypyridine derivatives and its application for correction of osteoporosis

“…The LHT 21-16 compound has a wide spectrum of pharmacological activity (Trunov et al 2020;Peresypkina et al 2020;Kesarev et al 2017). A comprehensive study of its biological properties allowed us to establish that it can act as a potential and effective antihypoxant, antioxidant, hepato-, photo-radioprotector.…”