Endothelins &amp; erectile dysfunction

Ritchie, Robert W.; Sullivan, M.

doi:10.1016/j.phrs.2010.12.006

Cited by 38 publications

(35 citation statements)

References 46 publications

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“…Morton et al [97] assessed the response of dorsal and cavernosal penile arteries on αAR-selective agonists and antagonists in the rabbit. Endothelins Endothelins (ETs) have been demonstrated in penile erectile tissues and may have different roles in erectile function, including maintenance of CC smooth muscle tone [98]. Stimulation of prejunctional α2-ARs in horse penile resistance arteries was also shown to inhibit relaxation-mediating NANC transmitter release [96].…”

Section: Erectile Dysfunctionmentioning

confidence: 99%

Erectile Dysfunction

Shamloul¹,

Bella²

2014

Colloquium Series on Integrated Systems Physiology: From Molecule to Function

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Section: Erectile Dysfunctionmentioning

confidence: 99%

Erectile Dysfunction

Shamloul¹,

Bella²

2014

Colloquium Series on Integrated Systems Physiology: From Molecule to Function

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“…Current studies did show a significant alteration of the erectile response despite inhibition of contraction to exogenous ET-1 using ET-1 receptor antagonists. ET-1 plays an important role in mineralocorticoid hypertension and is directly involved in end-organ damage, so ET-1 receptor blockade may provide a therapeutic approach to this hypertensive condition, or other clinical condition where ET-1 levels are increased such as in diabetes and systemic sclerosis (49)*.…”

Section: E- Treatment Of Ed In Hypertensive Patientsmentioning

confidence: 99%

New insights into hypertension-associated erectile dysfunction

Nunes

Labazi

Webb³

2012

Current Opinion in Nephrology and Hypertension

108

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Purpose of review Erectile dysfunction (ED) is recognized as a quality of life disorder that needs to be treated. Currently, it is estimated to affect as many as 30 million American men. Thirty percent of hypertensive patients complain of ED. The understanding of common mechanisms involved in the etiology of ED associated with hypertension, and the investigation of antihypertensive drugs that impact ED, will provide important tools toward indentifying new therapeutic targets that will improve the quality of life for patients in these conditions. Recent findings Hypertension and ED are closely intertwined diseases which have endothelium dysfunction as a common base. During hypertension and/or ED, disturbance of endothelium derived factors can lead to an increase in vascular smooth muscle (VSM) contraction. Hypertension can also lead to ED as a consequence of high blood pressure (BP) or due to antihypertensive treatment. However, growing evidence suggests ED as an early sign for hypertension. Also, some PDE-5 inhibitors used to treat ED can improve BP, but the link between these conditions has not been totally understood. Summary This review will discuss the interplay between hypertension and ED, exploring newest insights regarding hypertension-associated ED, as well as the effect of antihypertensive drugs in ED patients.

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“…An imbalance in favour of the vasoconstrictors has been demonstrated in both type 1 and 2 diabetes. 9,10 Such an imbalance seems to be caused by several factors, all playing equal roles, such as decreased NO production from either nitrergic nerves or endothelium, 10 low responsiveness of the smooth muscle to vasodilators, 1 upregulation of the receptors for vasoconstrictor mediators such as endothelin 11 and increased vasoconstrictor production and/or release and hyper-responsiveness to vasoconstrictors. 12 It is important to study the progression of ED in a temporal fashion in order to gain a better understanding of the pathophysiology of the condition.…”

Section: A Need For Temporal Analysismentioning

confidence: 99%

Pathophysiology of diabetic erectile dysfunction: potential contribution of vasa nervorum and advanced glycation endproducts

et al. 2012

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Erectile dysfunction (ED) due to diabetes mellitus remains difficult to treat medically despite advances in pharmacotherapeutic approaches in the field. This unmet need has resulted in a recent re-focus on the pathophysiology, in order to understand the cellular and molecular mechanisms leading to ED in diabetes. Diabetes-induced ED is often resistant to PDE5 inhibitor treatment, thus there is a need to discover targets that may lead to novel approaches for a successful treatment. The aim of this brief review is to update the reader in some of the latest development on that front, with a particular focus on the role of impaired neuronal blood flow and the formation of advanced glycation endproducts.

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Endothelins & erectile dysfunction

Cited by 38 publications

References 46 publications

Erectile Dysfunction

Erectile Dysfunction

New insights into hypertension-associated erectile dysfunction

Pathophysiology of diabetic erectile dysfunction: potential contribution of vasa nervorum and advanced glycation endproducts

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