Endothelins: a family of regulatory peptides. State-of-the-art lecture.

Protein kinase C inhibitors enhance endothelin‐1 and attenuate vasopressin and angiotensin II evoked [Ca2+]i elevation in the rat cardiomyocyte

“…In vascular smooth muscle tissue, ET-1-evoked vasoconstriction was reversed by H-7, a nonselective PKC inhibitor (Sugiura et al, 1989). An increase in the prolonged secondary phase of Ca2+ mobilization was demonstrated previously with a fixed high concentration of ET-1 in either STS or phorbol ester pretreated rat mesangial single cells (Iijima et al, 1991;Simonson & Dunn, 1991 (Chardonnens et al, 1990). However, the mechanism underlying the diminished response to these agonists needs further study.…”

Endothelin-1 decreases CD36 protein expression in vascular smooth muscle cells

“…It also stimulates DNA synthesis in VSMCs and thus is suspected to play an important role in the development of various circulatory disorders, including hypertension and atherosclerosis (29). After being secreted from endothelial cells, ET-1 binds to specific receptors on nearby VSMCs and perhaps on VSMCs at other distal sites (35). Two distinct types of ET receptors, ET A and ET B , have been cloned and sequenced from bovine and rat tissues (8,33).…”

Anatomy and Vascular Biology of the Cells in the Portal Circulation

“…Endothelin-1, a potent vasoactive 21-amino-acid peptide secreted by endothelial as well as other cell types, has been shown to exert a multifunctional role in a variety of tissues and cells (48)(49)(50), including the liver. Infusion of ET-1 in the isolated perfused rat liver causes a sustained and dose-dependent increase in portal pressure associated with increased glycogenolysis and oxygen consumption (51)(52)(53).…”