Endothelin type A receptor blockade increases renoprotection in congestive heart failure combined with chronic kidney disease: Studies in 5/6 nephrectomized rats with aorto-caval fistula

Kala, Petr; Vaňourková, Zdeňka; Škaroupková, Petra; Kompanowska‐Jezierska, Elżbieta; Sadowski, Janusz; Walkowska, Agnieszka; Veselka, Josef; Táborský, Miloš; Maxová, Hana; Vaněčková, Ivana; Červenka, Luděk

doi:10.1016/j.biopha.2022.114157

Cited by 2 publications

(3 citation statements)

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“…The values of GSI < 0.5 and TSI < 0.4 are considered as healthy renal tissue without sign of significant renal damage. This method is always employed in our studies evaluating the degree of kidney damage [ 26 , 44 , 45 ].…”

Section: Methodsmentioning

confidence: 99%

“…Indeed, we found recently that 15-weeks’ blockade of the RAS with angiotensin-converting enzyme inhibitor (ACEi) attenuated eccentric cardiac hypertrophy and improved ejection fraction without restoring RBF [ 23 ], whereas the blockade of RAS by ANG II type 1 (AT 1 ) receptor antagonist improved cardiac function and restored RBF. This implies beneficial effects of RAS blockade on the survival of hypertensive TGR with ACF-induced HF [ 25 , 44 , 45 , 80 ] and indicates different effects of the blockade depending on the use of ACEi or AT 1 receptor inhibition. Future studies are needed to address this issue, however, they would be difficult to perform: either blockade would decrease BP and hypotension is one of major adverse effects of pharmacological treatment in HF [ 3 – 6 ].…”

Section: Limitations Of the Studymentioning

confidence: 99%

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Impaired renal autoregulation and pressure-natriuresis: any role in the development of heart failure in normotensive and angiotensin II-dependent hypertensive rats?

Honetschlägerová,

Sadowski,

Kompanowska-Jezierska

et al. 2023

Hypertens Res

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The aim of the present study was to assess the autoregulatory capacity of renal blood flow (RBF) and of the pressure-natriuresis characteristics in the early phase of heart failure (HF) in rats, normotensive and with angiotensin II (ANG II)-dependent hypertension. Ren-2 transgenic rats (TGR) were employed as a model of ANG II-dependent hypertension. HF was induced by creating the aorto-caval fistula (ACF). One week after ACF creation or sham-operation, the animals were prepared for studies evaluating in vivo RBF autoregulatory capacity and the pressure-natriuresis characteristics after stepwise changes in renal arterial pressure (RAP) induced by aortic clamping. In ACF TGR the basal mean arterial pressure, RBF, urine flow (UF), and absolute sodium excretion (UNaV) were all significantly lower tha n in sham-operated TGR. In the latter, reductions in renal arterial pressure (RAP) significantly decreased RBF whereas in ACF TGR they did not change. Stepwise reductions in RAP resulted in marked decreases in UF and UNaV in sham-operated as well as in ACF TGR, however, these decreases were significantly greater in the former. Our data show that compared with sham-operated TGR, ACF TGR displayed well-maintained RBF autoregulatory capacity and improved slope of the pressure-natriuresis relationship. Thus, even though in the very early HF stage renal dysfunction was demonstrable, in the HF model of ANG II-dependent hypertensive rat such dysfunction and the subsequent HF decompensation cannot be simply ascribed to impaired renal autoregulation and pressure-natriuresis relationship.

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Section: Methodsmentioning

confidence: 99%

Section: Limitations Of the Studymentioning

confidence: 99%

Impaired renal autoregulation and pressure-natriuresis: any role in the development of heart failure in normotensive and angiotensin II-dependent hypertensive rats?

Honetschlägerová,

Sadowski,

Kompanowska-Jezierska

et al. 2023

Hypertens Res

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Section: Weeksmentioning

confidence: 99%

Renal sympathetic denervation improves pressure-natriuresis relationship in cardiorenal syndrome: insight from studies with Ren-2 transgenic hypertensive rats with volume overload induced using aorto-caval fistula

Honetschlägerová,

Husková,

Kikerlová

et al. 2024

Hypertens Res

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The aim was to evaluate the effects of renal denervation (RDN) on autoregulation of renal hemodynamics and the pressure-natriuresis relationship in Ren-2 transgenic rats (TGR) with aorto-caval fistula (ACF)-induced heart failure (HF). RDN was performed one week after creation of ACF or sham-operation. Animals were prepared for evaluation of autoregulatory capacity of renal blood flow (RBF) and glomerular filtration rate (GFR), and of the pressure-natriuresis characteristics after stepwise changes in renal arterial pressure (RAP) induced by aortic clamping. Their basal values of blood pressure and renal function were significantly lower than with innervated sham-operated TGR (p < 0.05 in all cases): mean arterial pressure (MAP) (115 ± 2 vs. 160 ± 3 mmHg), RBF (6.91 ± 0.33 vs. 10.87 ± 0.38 ml.min–1.g–1), urine flow (UF) (11.3 ± 1.79 vs. 43.17 ± 3.24 µl.min–1.g–1) and absolute sodium excretion (UNaV) (1.08 ± 0.27 vs, 6.38 ± 0.76 µmol.min–1.g–1). After denervation ACF TGR showed improved autoregulation of RBF: at lowest RAP level (80 mmHg) the value was higher than in innervated ACF TGR (6.92 ± 0.26 vs. 4.54 ± 0.22 ml.min–1.g–1, p < 0.05). Also, the pressure-natriuresis relationship was markedly improved after RDN: at the RAP of 80 mmHg UF equaled 4.31 ± 0.99 vs. 0.26 ± 0.09 µl.min–1.g–1 recorded in innervated ACF TGR, UNaV was 0.31 ± 0.05 vs. 0.04 ± 0.01 µmol min–1.g–1 (p < 0.05 in all cases). In conclusion, in our model of hypertensive rat with ACF-induced HF, RDN improved autoregulatory capacity of RBF and the pressure-natriuresis relationship when measured at the stage of HF decompensation.

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Endothelin type A receptor blockade increases renoprotection in congestive heart failure combined with chronic kidney disease: Studies in 5/6 nephrectomized rats with aorto-caval fistula

Cited by 2 publications

References 64 publications

Impaired renal autoregulation and pressure-natriuresis: any role in the development of heart failure in normotensive and angiotensin II-dependent hypertensive rats?

Impaired renal autoregulation and pressure-natriuresis: any role in the development of heart failure in normotensive and angiotensin II-dependent hypertensive rats?

Renal sympathetic denervation improves pressure-natriuresis relationship in cardiorenal syndrome: insight from studies with Ren-2 transgenic hypertensive rats with volume overload induced using aorto-caval fistula

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