Endothelin receptors in cultured renal epithelial cells

Neuser, D; Zaiss, S.; Stasch, Johannes‐Peter

doi:10.1016/0014-2999(90)90536-f

Cited by 20 publications

(5 citation statements)

References 6 publications

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“…This anatomical arrangement would permit endothelins secreted into RIF to modulate cortical epithelial transport through endothelin receptors on the surface of cultured canine cells of distal nephron origin (42). Furthermore, rat cortical collecting tubules contain mRNA for the B-type endothelin receptor (43), which the present studies suggest mediates the described actions of endogenous endothelins.…”

Section: Discussionmentioning

confidence: 75%

Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats.

Wesson¹

1997

J. Clin. Invest.

105

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Section: Discussionmentioning

confidence: 75%

Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats.

Wesson¹

1997

J. Clin. Invest.

105

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“…Peptide binding, immunostaining, RT-PCR and functional studies convincingly demonstrate that the PT expresses ET receptors, albeit in smaller amounts than more distal nephron segments (226, 304, 431) (Figure 3). Despite some disparate results, the bulk of evidence indicates that PT (rat and human) likely express both ETA and ETB.…”

Section: Et and Sodium Transportmentioning

confidence: 78%

Physiology of Endothelin and the Kidney

Kohan

Inscho

Wesson

et al. 2011

Comprehensive Physiology

101

136

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Since its discovery in 1988 as an endothelial cell-derived peptide that exerts the most potent vasoconstriction of any known endogenous compound, endothelin (ET) has emerged as an important regulator of renal physiology and pathophysiology. This review focuses on how the ET system impacts renal function in health; it is apparent that ET regulates multiple aspects of kidney function. These include modulation of glomerular filtration rate and renal blood flow, control of renin release, and regulation of transport of sodium, water, protons and bicarbonate. These effects are exerted through ET interactions with almost every cell type in the kidney, including mesangial cells, podocytes, endothelium, vascular smooth muscle, every section of the nephron, and renal nerves. In addition, while not the subject of the current review, ET can also indirectly affect renal function through modulation of extrarenal systems, including the vasculature, nervous system, adrenal gland, circulating hormones and the heart. As will become apparent, these pleiotropic effects of ET are of fundamental physiologic importance in the control of renal function in health. In addition, to help put these effects into perspective, we will also discuss, albeit to a relatively limited extent, how alterations in the ET system can contribute to hypertension and kidney disease.

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“…3). In vitro autoradiography of rat kidney localized ET-1 binding to PTs (383), while ET-1 binds to LLC-PK 1 cells (536). Additionally, numerous studies, as described below, have reported direct modulation of PT function by ET.…”

Section: Endothelin and The Kidneymentioning

confidence: 99%

Regulation of Blood Pressure and Salt Homeostasis by Endothelin

Kohan

Rossi

Inscho

et al. 2011

Physiological Reviews

367

459

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Endothelin (ET) peptides and their receptors are intimately involved in the physiological control of systemic blood pressure and body Na homeostasis, exerting these effects through alterations in a host of circulating and local factors. Hormonal systems affected by ET include natriuretic peptides, aldosterone, catecholamines, and angiotensin. ET also directly regulates cardiac output, central and peripheral nervous system activity, renal Na and water excretion, systemic vascular resistance, and venous capacitance. ET regulation of these systems is often complex, sometimes involving opposing actions depending on which receptor isoform is activated, which cells are affected, and what other prevailing factors exist. A detailed understanding of this system is important; disordered regulation of the ET system is strongly associated with hypertension and dysregulated extracellular fluid volume homeostasis. In addition, ET receptor antagonists are being increasingly used for the treatment of a variety of diseases; while demonstrating benefit, these agents also have adverse effects on fluid retention that may substantially limit their clinical utility. This review provides a detailed analysis of how the ET system is involved in the control of blood pressure and Na homeostasis, focusing primarily on physiological regulation with some discussion of the role of the ET system in hypertension.

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Endothelin receptors in cultured renal epithelial cells

Cited by 20 publications

References 6 publications

Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats.

Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats.

Physiology of Endothelin and the Kidney

Regulation of Blood Pressure and Salt Homeostasis by Endothelin

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