Endothelin production by bovine oviduct epithelial cells

Rosselli, Marinella; Imthurn, Bruno; Macas, Ervin; Keller, Paul J.

doi:10.1530/jrf.0.1010027

Cited by 35 publications

(14 citation statements)

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“…Bovine epithelial cells from the ampullar segment of the oviduct were isolated and cultured using the method described previously by Rosselli et al (1994a). Briefly, the lumen of the oviduct was gently perfused with 10 ml HBSS.…”

Section: Epithelial Cell Culturementioning

confidence: 99%

“…The cells were allowed to attach and grow in complete culture medium for 6-7 days and were then used for the immunohistochemical localization of NOS. Epithelial cell purity was ascertained by criteria as previously reported (Rosselli et al, 1994a); characteristic cell morphology, growth pattern and positive immunostaining with anti-cytokeratin antibodies CK1 (Dako, Diagnostic AG, Zug, Switzerland).…”

Section: Epithelial Cell Culturementioning

confidence: 99%

“…Smooth muscle cell contraction and relaxation, cilary beats of the oviduct epithelial cells and regulation of the synthesis of oviduct-derived factors are essentially involved in this process. Recently we reported that endothelin, a potent contracting factor (Yanagisawa et al, 1991), is synthesized by bovine oviduct epithelial cells in vitro (Rosselli et al, 1994a) and is able to induce contraction of bovine oviduct segments (Rosselli et al, 1994b). We also demonstrated that the contractile effects of endothelin-1 on bovine oviducts are enhanced by the presence of TV-monomethyl-L-arginine monoacetate (L-NMMA), an inhibitor of nitric oxide (NO) synthesis.…”

Section: Introductionmentioning

confidence: 99%

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Identification of nitric oxide synthase in human and bovine oviduct

et al. 1996

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Nitric oxide synthase (NOS) is responsible for the biological production of nitric oxide (NO) in several organs. NOS activity has also been localized in the reproductive tract, although direct evidence for its presence in the human or bovine oviduct is still lacking. In the present study, four different techniques were used to identify the presence of NOS activity in human (n = 11) and bovine (n = 9) oviduct: (

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Section: Epithelial Cell Culturementioning

confidence: 99%

Section: Epithelial Cell Culturementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Identification of nitric oxide synthase in human and bovine oviduct

et al. 1996

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“…Rosselli et al (1994) observed ET-1 production by bovine oviduct epithelial cells and hypothesized the possible involvement of ET-1 in the muscular oviduct wall contraction. Moreover, ET-1 acts in bovine oviduct arteries by directly activating a homogenous population of ET-R type A in smooth muscle (Labadia et al 1997).…”

Section: Discussionmentioning

confidence: 98%

In vitro regulation of local secretion and contraction of the bovine oviduct: stimulation by luteinizing hormone, endothelin-1 and prostaglandins, and inhibition by oxytocin

Wijayagunawardane

Miyamoto²,

Taquahashi³

et al. 2001

Journal of Endocrinology

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The precise regulatory mechanisms of cyclic oviductal contraction in the cow are unclear. The purpose of this study was to evaluate the effect of luteinizing hormone (LH), steroids, prostaglandins (PGs) and peptides on the oviductal contraction and secretion of PGs and endothelin (ET-1). In addition, the cyclic expression of mRNA for ET-1 and its receptors (ET-R) was evaluated by reverse transcription-polymerase chain reaction (RT-PCR). In the in vitro microdialysis study, an infusion of LH alone or in combination with progesterone (P 4 ), estradiol-17 (E 2 ) and/or ET-1 stimulated pronounced release of PGE 2 , PGF 2 and ET-1 in the oviducts from cows in the follicular and postovulatory phases. The addition of LH, LH+P 4 +E 2 and/or ET-1 to the medium increased the amplitude of oviductal contraction. However, oxytocin (OT) completely blocked the responses of oviductal secretion and contraction. In contrast, these substances did not show any effect in the oviducts from cows in the mid luteal phase. Similar expression patterns of mRNA encoding for ET-R type A and type B were found, which were highest during the postovulatory phase, lower during the luteal phase, with the lowest expression during the follicular phase. We suggest that the preovulatory LH surge, together with increasing E 2 levels from the Graafian follicle and a basal P 4 from regressing corpora lutea (CL), stimulates maximum oviductal production of PG and ET-1, resulting in oviductal contraction for a rapid transport of gametes. OT released from the newly-formed CL may block these mechanisms, and slow contractions for transport of the embryo to the uterus.

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“…Additionally, ET-1 is produced by bovine OECs and is involved in oviduct muscle contractility [35]. We recently reported that PGE2, PGF2α, ET-1 and Ang II directly increase the amplitude of muscular contractions in the bovine oviduct in vitro [6,11].…”

Section: Discussionmentioning

confidence: 98%

Angiotensin II Secretion by the Bovine Oviduct is Stimulated by Luteinizing Hormone and Ovarian Steroids

Wijayagunawardane

Kodithuwakku

Silva

et al. 2009

Journal of Reproduction and Development

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Abstract. Angiotensin II (Ang II), a vasoactive peptide, is secreted by the bovine oviduct and is involved in modulation of local oviductal contraction. Ang II biosynthesis and release during the normal estrous cycle and the effects of luteinizing hormone (LH) and ovarian steroids on biosynthesis and secretion of Ang II were investigated. During the preovulatory period, increases in mRNA expression for Angiotensin converting enzyme 1 (ACE-1) and release of Ang II peptide were detected. Microdialysis of oviductal segments in vitro showed that LH alone significantly increased Ang II release, and combined infusion of LH+E2+P4 caused an increase in Ang II release. In cultured oviductal epithelial cells, LH increased Ang II release and ACE-1 mRNA expression, and E2+P4 enhanced stimulatory effect of LH on Ang II release and ACE-1 mRNA expression. Thus, it can be concluded that the oviductal Ang II system is upregulated by LH and ovarian steroids during the periovulatory period and may enhance local oviductal contraction. These events could stimulate transport of gametes to the fertilization site. Key words: Angiotensin II (Ang II), Angiotensin converting enzyme 1 (ACE-1), Fallopian tube, Luteinizing hormone (LH), Ovarian steroids, Uterine tube (J. Reprod. Dev. 55: [570][571][572][573][574][575] 2009) he oviduct controls simultaneous opposite movements of gametes to the fertilization site and passage of the embryo into the uterus at a precise developmental stage. Estrous cycle-dependent oviductal contractile patterns appear to be attributed to these timely movements of gametes and embryos. Studies of spontaneous oviductal contractile patterns in the cow have revealed that the amplitude and frequency of contractions are low during the luteal phase [1], and a gradual increase in contractile amplitude and frequency ouccrs concomitant with a rapid decrease in the progesterone (P4) level [2]. Both contractile amplitude and frequency reach their maximal values during estrus, and the values quickly diminish over the next 3 days [1,2].Angiotensin (Ang) II, the major bioactive peptide of the reninangiotensin system, is involved in autocrine/paracrine regulation of the oviduct [3]. It is a vasoactive peptide that is converted from Ang I by angiotensin-converting enzyme-1 (ACE-1). Ang I is produced from the precursor angiotensinogen by the enzymatic activity of renin. Expression of Ang II and Ang II receptor (Ang II-R) in the human fallopian tube has been demonstrated [4], and Ang II plays a role in regulating the composition of fallopian tube secretions [5]. We recently reported that Ang II is secreted by the bovine oviduct and stimulates oviductal contractions [6][7][8]. Indeed, in the bovine oviduct, Ang II stimulates release of prostaglandin E2 (PGE2), prostaglandin F2α (PGF2α), and endothelin-1 (ET-1), which are the predominant inducers of contractions [9][10][11]. Moreover, luteinizing hormone (LH) stimulates e production and release of these hormones by the bovine oviduct during this period, and estradiol-17β (E2) exert...

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Endothelin production by bovine oviduct epithelial cells

Abstract: SwitzerlandThe production of immunoreactive-endothelin by bovine

Cited by 35 publications

References 6 publications

Identification of nitric oxide synthase in human and bovine oviduct

Identification of nitric oxide synthase in human and bovine oviduct

In vitro regulation of local secretion and contraction of the bovine oviduct: stimulation by luteinizing hormone, endothelin-1 and prostaglandins, and inhibition by oxytocin

Angiotensin II Secretion by the Bovine Oviduct is Stimulated by Luteinizing Hormone and Ovarian Steroids

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