Endothelin enhances lipopolysaccharide-induced expression of inducible nitric oxide synthase in rat glial cells

Oda, Haruko; Murayama, Toshihiko; Sasaki, Yukio; Okada, Toshikazu; Nomura, Yasuyuki

doi:10.1016/s0014-2999(97)01369-1

Cited by 15 publications

(8 citation statements)

References 33 publications

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“…In rat glial cells, ET-1 via ET B receptors, seems to synergistically enhance lipopolysaccharide-induced expression of NOS-2, while having no effect on its own (Oda et al, 1997). However, our ®ndings using HNPE cells demonstrate that ET-1 is able to induce NOS-2 expression, both mRNA and protein levels, via ET A/B receptor activation.…”

contrasting

confidence: 51%

Endothelin-1 Induces Nitric Oxide Synthase-2 Expression in Human Non-pigmented Ciliary Epithelial Cells

Prasanna

Krishnamoorthy

Hulet

et al. 2000

Experimental Eye Research

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contrasting

confidence: 51%

Endothelin-1 Induces Nitric Oxide Synthase-2 Expression in Human Non-pigmented Ciliary Epithelial Cells

Prasanna

Krishnamoorthy

Hulet

et al. 2000

Experimental Eye Research

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“…Primary astrocyte cultures always contain microglial elements and/or macrophages to a varying but substantial degree. To eliminate the microglial cells, a "shaking" procedure for 1-18 h is generally employed to detach the microglia (Chao et al, 1996;Kim and Tauber, 1996;Oda et al, 1997). Microglial cells in primary cultures attach usually on top of the astrocyte layer, and they float into the medium during the "shaking" procedure.…”

Section: Discussionmentioning

confidence: 99%

Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: In vitro and in vivo studies

Possel

Noack

Putzke

et al. 2000

Glia

167

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“…ET-3, presumably acting at ET B R, induces cyclooxygenase-2 and prostaglandin E 2 expression in cultured astrocytes (Koyama et al, 1999) and potentiates the expression of inducible nitric oxide synthase induced by bacterial lipopolysaccharide (Oda et al, 1997).…”

Section: Peripheral Glia As Transducers Of Nociceptive Informationmentioning

confidence: 99%

Expression and Localization of Endothelin Receptors: Implications for the Involvement of Peripheral Glia in Nociception

et al. 2001

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The endothelins (ETs) are peptides that have a diverse array of functions mediated by two receptor subtypes, the endothelin A receptor (ET A R) and the endothelin B receptor (ET B R). Pharmacological studies have suggested that in peripheral tissues, ET A R expression may play a role in signaling acute or neuropathic pain, whereas ET B R expression may be involved in the transmission of chronic inflammatory pain. To begin to define the mechanisms by which ET can drive nociceptive signaling, autoradiography and immunohistochemistry were used to examine the distribution of ET A R and ET B R in dorsal root ganglia (DRG) and peripheral nerve of the rat, rabbit, and monkey. In DRG and peripheral nerve, ET A R-immunoreactivity was present in a subset of small-sized peptidergic and nonpeptidergic sensory neurons and their axons and to a lesser extent in a subset of medium-sized sensory neurons. However, ET B R-immunoreactivity was not seen in DRG neurons or axons but rather in DRG satellite cells and nonmyelinating ensheathing Schwann cells. Thus, when ETs are released in peripheral tissues, they could act directly on ET A R-expressing sensory neurons and on ET B R-expressing DRG satellite cells or nonmyelinating Schwann cells. These data indicate that ETs can have direct, nociceptive effects on the peripheral sensory nervous system and that peripheral glia may be directly involved in signaling nociceptive events in peripheral tissues.

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Endothelin enhances lipopolysaccharide-induced expression of inducible nitric oxide synthase in rat glial cells

Cited by 15 publications

References 33 publications

Endothelin-1 Induces Nitric Oxide Synthase-2 Expression in Human Non-pigmented Ciliary Epithelial Cells

Endothelin-1 Induces Nitric Oxide Synthase-2 Expression in Human Non-pigmented Ciliary Epithelial Cells

Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: In vitro and in vivo studies

Expression and Localization of Endothelin Receptors: Implications for the Involvement of Peripheral Glia in Nociception

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