Endothelin and atrial natriuretic peptide levels following radiocontrast exposure in humans

Clark, Barbara A.; Kim, Ducksoo; Epstein, Franklin H.

doi:10.1016/s0272-6386(97)90568-0

Cited by 66 publications

(50 citation statements)

References 32 publications

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“…After injection of contrast media, a transient increase is followed by a more prolonged decrease in renal blood flow in animals and humans [11]. Endothelin-1 has been implicated as the most likely causative agent in a number of studies [12,13]. The vasoactive effect of adenosine in different organs is dependent on the ratio of adenosine A 1 and A 2 receptors.…”

Section: Pathogenesis Of Cinmentioning

confidence: 99%

Contrast‐induced nephropathy

Pučelíková

Dangas

Mehran

2007

Cathet Cardio Intervent

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Contrast induced nephropathy (CIN) is an iatrogenic disorder, resulting from exposure to contrast media. Contrast-induced hemodynamic and direct cytotoxic effects on renal structures are highly evident in its pathogenesis, whereas other mechanisms are still poorly understood. CIN is typically defined as an increase in serum creatinine by either 0.5 mg/dl or by 25% from baseline within the first 2-3 days after contrast administration. Although rare in the general population, CIN has a high incidence in patients with an underlying renal disorder, in diabetics, and the elderly. The risk factors are synergistic in their ability to produce CIN. The best way to prevent CIN is to identify the patients at risk and to provide adequate peri-procedural hydration. The role of various drugs in prevention of CIN is still controversial and warrants future studies. Despite remaining uncertainty regarding the degree of nephrotoxicity produced by various contrast agents, in current practice non-ionic low-osmolar contrast media are preferred over the high-osmolar contrast media in patients with renal impairment.

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Section: Pathogenesis Of Cinmentioning

confidence: 99%

Contrast‐induced nephropathy

Pučelíková

Dangas

Mehran

2007

Cathet Cardio Intervent

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“…Intravascular administration of contrast medium induces exacerbated release of urinary endothelin in patients with impaired renal function. Human studies show no significant increase in plasma endothelin levels until a volume of contrast media administered is greater than 150 mL (Clark et al, 1997). However, in diabetic patients or in patients with renal insufficiency, significant endothelin levels are detected when less than 100 mL of contrast medium are administered intraarterially.…”

Section: Mechanisms Of Contrast-induced Nephropathy In Patients With mentioning

confidence: 97%

Contrast-Induced Nephropathy in Patients with Type 2 Diabetes Mellitus and Coronary Artery Disease: Update and Practical Clinical Applications

Katholi¹,

Katholi²

2011

Advances in the Diagnosis of Coronary Atherosclerosis

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“…The injection of RCM significantly increases plasma level of ANP in patients with or without renal insufficiency or diabetes mellitus (69,79)…”

Section: Anpmentioning

confidence: 99%

Clinical and Experimental Evidence for Prevention of Acute Renal Failure Induced by Radiographic Contrast Media

et al. 2005

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Abstract. Acute renal failure still occurs as a complication after radiographic examination using iodinated radiocontrast medium. The incidence rate of radiocontrast medium-induced nephropathy (radiocontrast nephropathy) is low (2 -3%) in general. However, the rate is remarkably elevated in patients with pre-existing renal insufficiency. Radiocontrast nephropathy is associated with increased morbidity and mortality, particularly in patients with percutaneous coronary interventions. Although the reduction in renal blood flow and direct toxic action on renal tubular cells are considered to be involved, little is known about the etiology of radiocontrast nephropathy. A number of agents that improve renal circulation have been clinically tested for prevention of radiocontrast nephropathy, but none of them has succeeded. Protection of renal tubular cells against oxidative stress is another approach to avoid radiocontrast nephropathy. Prophylactic effects of antioxidants such as N-acetylcysteine and ascorbic acid have been reported by several investigators, although the effectiveness of these compounds is still a matter of debate. At present, hydration is regarded as the only effective, though incomplete, prophylactic regimen for radiocontrast nephropathy. Recently, we have shown that caspasedependent apoptosis is an important factor in the pathogenesis of radiocontrast nephropathy and clarified cellular mechanisms underlying the radiocontrast media-induced apoptosis. This review summarizes clinical and experimental evidence for the etiology and prevention of radiocontrast nephropathy.

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Endothelin and atrial natriuretic peptide levels following radiocontrast exposure in humans

Cited by 66 publications

References 32 publications

Contrast‐induced nephropathy

Contrast‐induced nephropathy

Contrast-Induced Nephropathy in Patients with Type 2 Diabetes Mellitus and Coronary Artery Disease: Update and Practical Clinical Applications

Clinical and Experimental Evidence for Prevention of Acute Renal Failure Induced by Radiographic Contrast Media

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