Endothelin action on vascular smooth muscle involves inositol trisphosphate and calcium mobilization

Marsden, Philip A.; Danthuluri, N. Raju; Brenner, Barry M.; Ballermann, Barbara J.; Brock, Tommy A.

doi:10.1016/s0006-291x(89)80180-9

Cited by 339 publications

(99 citation statements)

References 20 publications

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“…The Cai" transients following ET-l addition to monolayers were similar to VSMCs and other cells [2,6,9,101, with respect to their dose-response curves and extracellular Ca2' dependency. Although a number of preparations failed to show an increase in Ca2+ in response to ET-I, specific '251-binding to cells was readily demonstrated in all preparations studied.…”

Section: Discussionmentioning

confidence: 63%

“…These findings suggest ET-l related Ca?' transients and activation of the Na+/H+ antiport are receptor mediated, possibly occurring through the phosphoinositide and diacylglycero1 signaling systems as shown in other cells [2,6].…”

Section: Discussionmentioning

confidence: 92%

“…may result from activation of voltage-sensitive Ca2+ channels, as many of the observed responses are dihydropyridinesensitive and dependent on extracellular Ca2+ [1, 3,10,11]. However, in VSMC ET-l also increases inositol phosphates in concert with a rise in Car" [2,5,12,13], indicating Ca2+ mobilization from intracellular stores.…”

Section: Introductionmentioning

confidence: 99%

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Calcium mobilization and Na⁺/H⁺ antiport activation by endothelin in human skin fibroblasts

1989

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 92%

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Calcium mobilization and Na⁺/H⁺ antiport activation by endothelin in human skin fibroblasts

1989

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“…Recent studies have demonstrated that the ET family is comprised of three structurally distinct isopeptides derived from separate genes (Inoue et al, 1989;Martin et al, 1990). ETs have been shown to activate a cell-surface receptor coupled to the second messenger system involving polyphosphoinositide (poly-PI) hydrolysis and an increase in cytosolic free Ca2+ ([Ca*'],) (Araki et al, 1989;Kasuya et al, 1989;Marsden et al, 1989;Lin et al, 19900;Zhanget al, 1990). There is evidence that the increase in [Ca2+Ii is produced both by intracellular mobilization and through influx from an extracellular source (Hamilton et al, 1989;Zhang et al, 1990).…”

mentioning

confidence: 99%

Endothelin‐Mediated Calcium Response and Inositol 1,4,5‐Trisphosphate Release in Neuroblastoma‐Glioma Hybrid Cells (NG108‐15): Cross Talk with ATP and Bradykinin

Chau

Lin

Chang

et al. 1993

Journal of Neurochemistry

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“…Ihara et al (1991b) demonstrated that vascular smooth muscle cells express both ETA and ETB receptors, while Donoso et al (1992) demonstrated marked differences in the ET-1 responses between the epididymal and prostatic segments of the rat vas deferens. Obviously, neither the available techniques nor current knowledge on ET-1 and ATP pharmacodynamics are sufficient to allow resolution of this question (Van Renterghem et al, 1988;Marsden et al, 1989;Highsmith et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

Involvement of ET_A receptors in the facilitation by endothelin‐1 of non‐adrenergic non‐cholinergic transmission in the rat urinary bladder

Donoso

Salas

Sepulveda

et al. 1994

British J Pharmacology

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1 Endothelin-1 (ET-1; 3-10 nM) raised the tone of rat bladders bathed in buffer containing atropine (1 gtM) plus guanethidine (3.4 JAM). In addition, ET-1 potentiated, in a concentration-dependent fashion (1-10 nM), the contractions evoked by both transmural nerve stimulation and applications of exogenous adenosine 5'-triphosphate (ATP). 2 The threshold concentration of ET-1 required to facilitate non-adrenergic non-cholinergic (NANC) transmission and potentiate ATP-induced contractions, was about 10 fold lower than that required to increase the bladder tone (3 nM). 3 The ET-1-induced increase in basal tension reached its maximal effect within 60-90 s. In contrast, the 7.8 JAM ATP-induced contractions increased by 50% within the first minute following incubation with 1O nM ET-1 but required about 5 min to develop the maximal effect. 4 The ET-1-induced potentiation of NANC or ATP responses was long-lasting and persisted in spite of extensive washing. The recovery of the bladder excitability depended on the concentration of ET-1. Following the application of 3 nM ET-1, recovery required 30 min; applications of 10 nM ET-1 required at least 60 min for full recovery. 5The ET-1-induced potentiation of responses was selective for ATP and related structural analogues.ET-1 did not modify the contractions induced by acetylcholine, 5-hydroxytryptamine, prostaglandin F2, or bradykinin. 6 The potency of ET-2 was similar to that of ET-1. ET-3 and ET-C-terminal hexapeptide were inactive up to 100 M. Sarafotoxin S6b was 2 to 3 fold less potent than ET-1 whereas sarafotoxin S6c (100 nM) was inactive. AGETB-9 and AGETB-89, two ETB receptor agonists, were also inactive (up to 100 nM). 7 Removal of one or both disulphide bonds in ET-1 and tryptophan-21 formylation of ET-1, resulted in inactive peptides (up to 100 nM). 8 The ET-1 receptor antagonists, BE-18257B and FR 139317, blocked both the ET-1-induced rise in tone and the potentiation of ATP responses in a concentration-dependent fashion. FR 139317 was at least 30 fold more potent than BE-18257B. Both antagonists blocked at lower concentrations the ET-l increase in bladder tone as compared to the ATP potentiation. The antagonism was slowly reversible. 9 Results are consistent with the presence of ETA receptors in the rat bladder, which mediate both actions of ET-1. The interaction of ET-1 with purinergic mechanisms is discussed.

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Endothelin action on vascular smooth muscle involves inositol trisphosphate and calcium mobilization

Cited by 339 publications

References 20 publications

Calcium mobilization and Na⁺/H⁺ antiport activation by endothelin in human skin fibroblasts

Calcium mobilization and Na⁺/H⁺ antiport activation by endothelin in human skin fibroblasts

Endothelin‐Mediated Calcium Response and Inositol 1,4,5‐Trisphosphate Release in Neuroblastoma‐Glioma Hybrid Cells (NG108‐15): Cross Talk with ATP and Bradykinin

Involvement of ET_A receptors in the facilitation by endothelin‐1 of non‐adrenergic non‐cholinergic transmission in the rat urinary bladder

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Endothelin action on vascular smooth muscle involves inositol trisphosphate and calcium mobilization

Cited by 339 publications

References 20 publications

Calcium mobilization and Na+/H+ antiport activation by endothelin in human skin fibroblasts

Calcium mobilization and Na+/H+ antiport activation by endothelin in human skin fibroblasts

Endothelin‐Mediated Calcium Response and Inositol 1,4,5‐Trisphosphate Release in Neuroblastoma‐Glioma Hybrid Cells (NG108‐15): Cross Talk with ATP and Bradykinin

Involvement of ETA receptors in the facilitation by endothelin‐1 of non‐adrenergic non‐cholinergic transmission in the rat urinary bladder

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Calcium mobilization and Na⁺/H⁺ antiport activation by endothelin in human skin fibroblasts

Calcium mobilization and Na⁺/H⁺ antiport activation by endothelin in human skin fibroblasts

Involvement of ET_A receptors in the facilitation by endothelin‐1 of non‐adrenergic non‐cholinergic transmission in the rat urinary bladder