Endothelin Abnormalities in Patients With Pulmonary Embolism

Miceli, Sofia; Faraone, Stanislao; Alifano, Marco; Micco, Assunta; Albisinni, Rosina; Maniscalco, Mauro; Minno, Giovanni Di

doi:10.1378/chest.111.3.544

Cited by 34 publications

(18 citation statements)

References 23 publications

(3 reference statements)

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“…20,21 crease in renal ET production during acute exAs previously reported, 5 we found that urine exacerbation which occurs in the absence of significant cretion resulted increased in COPD during exchanges of ET circulating levels correlating both to acerbation. Currently, we think that this abnormality changes in GFR and impairment of respiratory funccould be related to an increased renal ET production tion.…”

supporting

confidence: 81%

Abnormalities of Renal Endothelin during Acute Exacerbation in Chronic Obstructive Pulmonary Disease

Miceli

Maniscalco

Celentano³

et al. 2001

Pulmonary Pharmacology & Therapeutics

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supporting

confidence: 81%

Abnormalities of Renal Endothelin during Acute Exacerbation in Chronic Obstructive Pulmonary Disease

Miceli

Maniscalco

Celentano³

et al. 2001

Pulmonary Pharmacology & Therapeutics

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“…As we observed in rat with APAE, mRNA expression of ET A -Rs is up-regulated in PH and ET-1 plasma levels were increased. Elevated circulating plasma levels of ET-1 has also been reported in a number of pathological conditions, especially in disorders associated with primary and secondary PH in both patient and animal models, and in patients with acute PE [8].…”

Section: Discussionmentioning

confidence: 93%

“…Blockade of the ET system by ET A -R antagonists has been shown to attenuate the development of PH in monocrotaline-and hypoxic-rats [6,7]. Other studies have demonstrated abnormalities of the ET system in patients with PE [8]. Additional non-clinical studies assessing the implication of the ETs in rabbit, canine and porcine models of PE using either selective or non-selective ET-R antagonists [9][10][11][12][13][14][15] have provided further support.…”

Section: Introductionmentioning

confidence: 94%

Effects of a selective endothelin A receptor antagonist, ABT-627, in healthy normotensive anaesthetized rats developing acute pulmonary air embolism

et al. 2002

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Acute pulmonary air embolism (APAE) injures the vascular endothelium in the lung and results in pulmonary hypertension (PH). Endothelins (ETs), a family of potent vasoactive peptides, are known to be associated with PH of various aetiologies. We evaluated the effects of ABT-627, a selective ET(A) receptor (ET(A)-R) antagonist in a rat model of APAE over 3 h. APAE rats developed a higher right ventricular systolic pressure (RVSP), lower mean arterial blood pressure (MABP), and had lower PaO(2). At 3 h, arterial plasma levels of ET-1 were increased. ABT-627-treated controls showed no effects. However, ABT-627 significantly lowered RVSP during APAE, abolished the short recovery phase (within 10-25 min) of MABP without affecting the subsequent lowering of MABP, and improved oxygen saturation in APAE rats. These results show that ET(A)-R subtype is involved in the pathogenesis of APAE since a blockade of this receptor subtype attenuated the cardiopulmonary deterioration and improved blood gas exchanges in rats with this disease.

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“…Elevated levels of anticardiolipin antibodies [11] , endothelial factor VIII [12,13] , monocyte chemoattractant protein 1 [14] , and endothelins [15,16] have been found to be elevated in PTE. In a study that included 38 patients with PTE and 38 age-and gender-matched healthy subjects without risk factors for pulmonary embolism, levels of asymmetric dimethylarginine, TNF-α, total antioxidant status, total oxidant status, and oxidative stress index showed a significant difference between the patient and control groups [17] .…”

Section: Discussionmentioning

confidence: 99%

Subclinical Atherosclerosis in Patients with Prior Pulmonary Thromboembolism

Buyukterzi

Kurtipek³

et al. 2017

Med Princ Pract

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Objective: Recent studies have indicated that endothelial dysfunction is common in patients with a prior history of pulmonary thromboembolism (PTE). Based on the established relationship between endothelial dysfunction and atherosclerosis, we aimed to investigate carotid intima-media thickness (cIMT) as a marker of subclinical atherosclerosis in patients who have a prior history of PTE. Subjects and Methods: Medical records belonging to patients with a history of PTE and age- and gender-matched control subjects among those who underwent transthoracic echocardiography in Konya Training and Research Hospital were reviewed. Echocardiographic findings and cIMT measurements were recorded. cIMT measurements were compared between patient and control groups, and then independent correlates of cIMT were investigated using appropriate statistical methods. Results: A total of 110 patients (64.02 ± 12.67 years, males: n = 79 [71.81%]; females: n = 31 [28.19%]) were found to be eligible for assessment. Of these patients, 55 (50.00%) had a history of PTE. Patients with a history of PTE had significantly greater cIMT (p = 0.040). In this group of patients, cIMT positively and significantly correlated with basal right ventricular (RV) diameter (r = 0.271, p = 0.022), RV diastolic area (r = 0.376, p = 0.002), and systolic pulmonary artery pressure (r = 0.248, p = 0.037). In the multivariate linear regression analysis, only RV diastolic area was independently associated with cIMT in patients with PTE (p = 0.010). Conclusion: Patients with a history of PTE have increased cIMT when compared to healthy subjects, and cIMT, which is a marker of subclinical atherosclerosis, is independently associated with RV diameter in these patients.

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Endothelin Abnormalities in Patients With Pulmonary Embolism

Cited by 34 publications

References 23 publications

Abnormalities of Renal Endothelin during Acute Exacerbation in Chronic Obstructive Pulmonary Disease

Abnormalities of Renal Endothelin during Acute Exacerbation in Chronic Obstructive Pulmonary Disease

Effects of a selective endothelin A receptor antagonist, ABT-627, in healthy normotensive anaesthetized rats developing acute pulmonary air embolism

Subclinical Atherosclerosis in Patients with Prior Pulmonary Thromboembolism

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