Endothelin-1 Regulation of Exercise-Induced Changes in Flow: Dynamic Regulation of Vascular Tone

Rapoport, Robert M.; Merkus, Daphne

doi:10.3389/fphar.2017.00517

Cited by 13 publications

(10 citation statements)

References 60 publications

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“…shear forces exerted by blood flow, are also translated by the glycocalyx layer (glycoproteins and proteoglycans) located on the luminal surface of endothelium into a vasodilatory response. This pulsatile flow-induced shear stress and release of nitric oxide induces a dynamic regulation of vascular tone via ET-1 synthesis/release [91], which could also potentiate the nonnutritive route of the blood flow. Vasodilation and additional microvascular units expand the endothelial surface area, thus enabling the delivery of nutrients to the muscle.…”

Section: Muscle-centric Vs Integrative View Of the Impact Of Exercisementioning

confidence: 99%

Exercise and metabolic health: beyond skeletal muscle

2020

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Regular exercise is a formidable regulator of insulin sensitivity and overall systemic metabolism through both acute events driven by each exercise bout and through chronic adaptations. As a result, regular exercise significantly reduces the risks for chronic metabolic disease states, including type 2 diabetes and non-alcoholic fatty liver disease. Many of the metabolic health benefits of exercise depend on skeletal muscle adaptations; however, there is plenty of evidence that exercise exerts many of its metabolic benefit through the liver, adipose tissue, vasculature and pancreas. This review will highlight how exercise reduces metabolic disease risk by activating metabolic changes in non-skeletal-muscle tissues. We provide an overview of exercise-induced adaptations within each tissue and discuss emerging work on the exercise-induced integration of inter-tissue communication by a variety of signalling molecules, hormones and cytokines collectively named 'exerkines'. Overall, the evidence clearly indicates that exercise is a robust modulator of metabolism and a powerful protective agent against metabolic disease, and this is likely to be because it robustly improves metabolic function in multiple organs.

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Section: Muscle-centric Vs Integrative View Of the Impact Of Exercisementioning

confidence: 99%

Exercise and metabolic health: beyond skeletal muscle

2020

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“…In the culture of rat ophthalmic arteries, ET-1 can mediate vasoconstriction ( 21 ). There is substantial evidence that, in numerous pathophysiologies associated with endothelial dysfunction, ET-1 may release potent vasoconstrictors and sustain elevated vascular tone; however, there is considerably less data to support the role of ET-1 in the regulation of vascular tone under physiological conditions ( 22 – 24 ). In addition, ET-1 also serves a role in osteogenesis and bone remodeling.…”

Section: Introductionmentioning

confidence: 99%

Endothelial cells and endothelin‑1 promote the odontogenic differentiation of dental pulp stem cells

Liu

Zhao

et al. 2018

Mol Med Report

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It has been established that dental pulp stem cells (DPSCs) serve an important role in the restoration and regeneration of dental tissues. DPSCs are present in blood vessels and also exist in the vessel microenvironment in vivo and have a close association with endothelial cells (ECs). The present study aimed to evaluate the influence of ECs and their secretory product endothelin-1 (ET-1) on the differentiation of DPSCs. In the present study, cells were divided into four groups: i) a DPSC-only control group; ii) a DPSC with ET-1 administration group; iii) a DPSC and human umbilical vein endothelial cell (HUVEC) direct co-culture group; and iv) a DPSC and HUVEC indirect co-culture group using a Transwell system. Reverse transcription-quantitative polymerase chain reaction was used to detect the expression of the odontoblastic differentiation-associated genes, including dentin sialoprotein (DSP) and dentin matrix acidic phosphoprotein 1 (DMP-1) at days 4, 7, 14 and 21. Alizarin Red S staining, immunofluorescence and western blot analyses were also conducted to assess the differentiation of the DPSCs in each group. The highest expression levels of odontoblastic differentiation-associated genes were observed on day 7 and in the two co-culture groups were increased compared with the DPSC-only and DPSC + ET-1 culture groups at all four time points. However, expression levels in the DPSC + ET-1 group were not downregulated as notably as in the co-culture groups on days 14 and 21. The Transwell group exhibited the greatest ability for odontoblastic differentiation compared with the other groups according to staining with Alizarin Red S, immunofluorescence and western blot analysis results. According to the results of the present study, the culture solution with HUVECs affected the differentiation of DPSCs. In addition, ET-1 may promote the odontoblastic differentiation of DPSCs.

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“…The microarray study also revealed in tPA-treated arteries changes in the expression of four genes related to vascular tone regulation, such as endothelin receptor or angiotensin receptor (Watanabe et al, 2005; Rapoport and Merkus, 2017). One of those genes - corticotrophin releasing factor receptor (U53486) is also involved in nervous system function.…”

Section: Discussionmentioning

confidence: 94%

Oligonucleotide Microarrays Identified Potential Regulatory Genes Related to Early Outward Arterial Remodeling Induced by Tissue Plasminogen Activator

et al. 2019

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Constrictive vascular remodeling limiting blood flow, as well as compensatory outward remodeling, has been observed in many cardiovascular diseases; however, the underlying mechanisms regulating the remodeling response of the vessels remain unclear. Plasminogen activators (PA) are involved in many of the processes of vascular remodeling. We have shown previously that increased levels of tissue-type PA (tPA) contributes to outward vascular remodeling. To elucidate the mechanisms involved in the induction of outward remodeling we characterized changes in the expression profiles of 8799 genes in injured rat carotid arteries 1 and 4 days after recombinant tPA treatment compared to vehicle. Periadventitial tPA significantly increased lumen size and vessel area, encompassed by the external elastic lamina, at both one and 4 days after treatment. Among 41 differentially expressed known genes 1 day after tPA application, five genes were involved in gene transcription, five genes were related to the regulation of vascular tone [for example, thromboxane A2 receptor (D32080) or non-selective-type endothelin receptor (S65355)], and eight genes were identified as participating in vascular innervation [for example, calpain (D14478) or neural cell adhesion molecule L1 (X59149)]. Four days after injury in tPA-treated arteries, four genes, regulating vascular tone, were differentially expressed. Thus, tPA promotes outward arterial remodeling after injury, at least in part, by regulating expression of genes in the vessel wall related to function of the nervous system and vascular tone.

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Endothelin-1 Regulation of Exercise-Induced Changes in Flow: Dynamic Regulation of Vascular Tone

Cited by 13 publications

References 60 publications

Exercise and metabolic health: beyond skeletal muscle

Exercise and metabolic health: beyond skeletal muscle

Endothelial cells and endothelin‑1 promote the odontogenic differentiation of dental pulp stem cells

Oligonucleotide Microarrays Identified Potential Regulatory Genes Related to Early Outward Arterial Remodeling Induced by Tissue Plasminogen Activator

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