Endothelin-1 in patients with complicated and uncomplicated myocardial infarction

Abstract

Endothelin-1 concentrations were measured in peripheral venous blood samples from 42 patients with acute myocardial infarction. In patients with ischemic or hemodynamic complications (n = 11), endothelin-1 concentrations were significantly higher already on admission (P = 0.008) and remained significantly higher until day 6 after admission compared to patients with uncomplicated infarctions (n = 31; P = 0.035). There were no close correlations between peak concentrations of endothelin-1 and creatine kinase or creatine kinase isoenzyme MB mass in either group. Only in complicated patients did left ventricular ejection fraction correlate closely and inversely with peak endothelin-1 concentrations (r = -0.71; P = 0.03). Therefore, plasma endothelin-1 concentrations in patients with acute myocardial infarction patients may reflect states of markedly depressed cardiac performance and recurrent myocardial ischemia.

A novel peptide of endothelin family, 31 amino-acid length endothelin in patients with acute myocardial infarction

“…Miyauchi et al (14) and others (12,16,(28)(29)(30) has been reported that plasma concentration of ET-1(1-21) in patients with acute myocardial infarction significantly rose after an attack and gradually decreased, and returned to the normal level in approximately two weeks. Furthermore, plasma concentrations of ET-1(1-21) rose after laparotomy and thoracotomy (31), coronary artery bypass grafting (32), and PTCA (33,34), and these values were gradually normalized after surgery.…”

Relationship between serum endothelin-1 level and spontaneous reperfusion in patients with acute myocardial infarction

“…It has been reported that circulating ET-1 increases in the early hours after AMI [18,19], peaks within the first 24 h, and remains elevated after 48 h [18]. It has been reported that circulating ET-1 increases in the early hours after AMI [18,19], peaks within the first 24 h, and remains elevated after 48 h [18].…”

Endothelin in cardiovascular control: The role of endothelin antagonists

“…Interestingly, ET(B) receptors are upregulated in atherosclerotic human coronary arteries, although their functional role is unclear [66]. In patients with complicated acute myocardial infarction, ET-1 plasma levels are increased; the persistence of this increase depends on the severity of myocardial infarction [67,68]. In human atherosclerosis and experimental hypercholesterolemia, elevated plasma levels for ET hav been described [56].…”