Endothelin-1 as a therapeutic target in autosomal dominant polycystic kidney disease

Raina, Rupesh; Chauvin, Abigail; Vajapey, Ramya; Khare, Anshika; Krishnappa, Vinod

doi:10.5414/cn109598

Cited by 2 publications

(3 citation statements)

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“…ET-1 is an endothelial-derived systemic and intraglomerular mediator of blood flow. 68 It acts as a vasoconstrictor in the renal cortex and a vasodilator in the renal medulla, and its actions are mediated by NO. 69 Focal ischemia, hypoxia, and increased angiotensin II caused by cyst growth are strong stimulators of ET-1.…”

Section: Hypertensionmentioning

confidence: 99%

“… 69 , 70 It is speculated that ET-1 has a compensatory role in early ADPKD to maintain blood flow to medullary areas obstructed by cysts and to maintain sodium balance in the setting of tubular loss; however, this role becomes pathogenic as disease progresses, contributing to elevated BP and sodium retention, particularly in the setting of reduced NO mediation. 68 , 69 , 70 , 71 …”

Section: Hypertensionmentioning

confidence: 99%

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Cardiovascular Manifestations and Management in ADPKD

Sagar

Rangan

2023

Kidney International Reports

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Section: Hypertensionmentioning

confidence: 99%

Section: Hypertensionmentioning

confidence: 99%

Cardiovascular Manifestations and Management in ADPKD

Sagar

Rangan

2023

Kidney International Reports

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“…Данные об экспрессии ET-2 менее обширны, но, по крайней мере на уровне мРНК, ET-2, по-видимому, присутствует в почках большинства видов. Высвобождение эндотелинов из поляризованных клеток происходит аблюминально [6], что подчеркивает важность этой системы как паракринного/ аутокринного модулятора функции почек.…”

Section: The Role Of Endothelin Receptors In the Regulation Of Kidney...unclassified

The Role of Endothelin Receptors in the Regulation of Kidney Function and Blood Pressure

Chaulin¹,

Grigoreva²,

Suvorova³

2022

НО БН (SR BS)

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Recently, the endothelin system consisting of three main peptides (ET-1, ET-2, ET-3) and two types of receptors (ETA and ETB) has been considered as one of the key regulators of kidney function and blood pressure, the maintenance of which has a vital role for the human body. Understanding the exact role and regulatory mechanisms of the endothelin system is the foundation for improving diagnostic and therapeutic approaches in the management of patients suffering from hypertension and renal pathologies. The purpose of this article is to systematize information about the role of endothelin receptors in the regulation of kidney function and blood pressure. To achieve this goal, the analysis of foreign literature on Embase and Pubmed databases was carried out. According to the results of the literature analysis, it was revealed that the endothelin system plays an important role in the regulation of kidney function and blood pressure, controlling the body's water-salt homeostasis and the tone (diameter of the lumen) of arterial vessels. Violation of the regulatory effects of the endothelin system contribute to the development of arterial hypertension. In addition, the endothelin system is involved in the pathogenesis of renal diseases. Further studies are needed to confirm and clarify the molecular mechanisms of regulation of kidney function and blood pressure, which will help to develop new groups of drugs for the treatment of kidney diseases and hypertension.

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Endothelin-1 as a therapeutic target in autosomal dominant polycystic kidney disease

Cited by 2 publications

References 0 publications

Cardiovascular Manifestations and Management in ADPKD

Cardiovascular Manifestations and Management in ADPKD

The Role of Endothelin Receptors in the Regulation of Kidney Function and Blood Pressure

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