Abstract:Objective: Systemic lupus erythematosus is a chronic rheumatic disorder. Endothelin-1, a vasoconstrictor, belongs to the endothelin family. To date, association between ET-1 and pathogenesis of SLE remains unclear.
Method: This case-control study was carried out by 314 SLE, 252 other inflammatory autoimmune diseases patients and 500 healthy controls. Serum ET-1, CCN3, IL-28B levels were detected by ELISA, and ET-1 gene polymorphisms (rs5369, rs5370, rs1476046, rs2070699, rs2071942, rs2071943, rs3087459, rs4145… Show more
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