Endothelialization of microporous polytetrafluoroethylene grafts in the infrarenal aorta and caval vein of the rat

Zdanowski, Zbigniew; Ribbe, Else; Bengmark, S

doi:10.1002/micr.1920130517

Cited by 8 publications

(4 citation statements)

References 19 publications

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“…As a consequence, far too short grafts of 10-to 15-mm length were implanted. [19][20][21][22][23][24][25] If one conservatively extrapolates the transanastomotic outgrowth rates in rats, 22,25,26 it is highly likely that these experimental grafts were all transanastomotically fully endothelialized within less than 10 weeks. Given the individual variability of transanastomotic outgrowth, transanastomotic confluence needs to be assumed even earlier.…”

Section: Discussionmentioning

confidence: 99%

Differentiating transmural from transanastomotic prosthetic graft endothelialization through an isolation loop-graft model

Pennel

Zilla

Bezuidenhout

2013

Journal of Vascular Surgery

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Although the mode of graft deployment has changed over the years, the problem of an absent surface endothelium remains, whether small- to medium-diameter grafts are surgically implanted or placed endovascularly as “covered stents.” In contrast to humans, most animal models experience progressive transanastomotic endothelial outgrowth. Together with graft lengths that were too short, the clinically irrelevant transanastomotic endothelialization inadvertently led to early endothelial confluence in the vast majority of experimental vascular graft studies pre-empting or concealing alternative modes of endothelialization. The isolation loop-graft model we propose allows the long-term differentiation of the different modes of endothelialization in a small animal screening model.

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Section: Discussionmentioning

confidence: 99%

Differentiating transmural from transanastomotic prosthetic graft endothelialization through an isolation loop-graft model

Pennel

Zilla

Bezuidenhout

2013

Journal of Vascular Surgery

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“…We previously reported that the endothelialization of PTFE grafts of 5 mm length was more rapid in the caval vein than in the aorta of the rat, prob- ably due to a more efficient formation of mural thrombus (26). At the venous side, slow blood flow and low blood pressure may obviously facilitate formation of mural thrombus, which in turn may enhance endothelialization.…”

Section: Discussionmentioning

confidence: 99%

Reduced Susceptibility of Polytetrafluoroethylene Vascular Prostheses to Colonization by Staphylococcus aureus Following In Situ Endothelialization

Zdanowski¹,

Hallberg²,

Schalén³

et al. 1994

Artificial Organs

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The impact of endothelialization of polytetrafluoroethylene (PTFE) grafts on susceptibility to experimental colonization by Staphylococcus aureus was studied in a rat model. One hundred and eight grafts (2 mm inner diameter, 5 mm length) were implanted into the infrarenal aorta (54 rats) or the infrarenal caval vein (54 rats). The progress of endothelialization following graft implantation was evaluated by SEM at 1, 3, 7, and 14 days on 6 grafts from each group. We found that the endothelialization was more rapid in caval vein than in aorta: The caval vein grafts were completely endothelialized 2 weeks following implantation compared with endothelialization of approximately 0.5 mm of aorta grafts, measured from each anastomosis. During this time, the resistance to standardized intravenous challenge with 10(8) colony-forming units of S. aureus increased gradually in both groups, and all caval vein grafts tested at 2 weeks were sterile. However, all aorta grafts challenged at 2 weeks were colonized, although to a somewhat lower degree than at earlier challenge. Resistance of PTFE grafts to colonization with S. aureus thus correlated to the degree of endothelialization.

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“…Zdanowski et al5 reported endothelialization after placement of a PTFE graft (2 mm inner diameter; 5 mm long) in the caval vein of rats. Fourteen days after implantation, endothelialization of the inner surface of the graft was found to have been completed.…”

Section: Discussionmentioning

confidence: 99%

Nine-year patency of a vascular prosthesis used for portal vein reconstruction during pancreatoduodenectomy

Takasaki

Yamamoto

Tsugita

et al. 1997

J Hep Bil Pancr Surg

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We report a patient in whom a polytetrafluoroethylene (PTFE) graft used for reconstruction of the portal vein was confirmed to be patent 9 years after pancreatoduodenectomy (which was performed when he was aged 51 years). The patient had advanced cancer of the head of the pancreas. Pancreatoduodenectomy was performed, and 6cm of the portal vein was resected. The portal vein was reconstructed with a PTFE graft (internal diameter 9ram; length about 6cm). The graft was demonstrated to be patent on angiography 3 years after the operation. A computed tomographic (CT) scan performed 9 years after the operation showed that the portal graft was still patent. About 2 years after the operation, the patient had been able to resume physical labor, similar to the work he performed before the operation.

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Endothelialization of microporous polytetrafluoroethylene grafts in the infrarenal aorta and caval vein of the rat

Cited by 8 publications

References 19 publications

Differentiating transmural from transanastomotic prosthetic graft endothelialization through an isolation loop-graft model

Differentiating transmural from transanastomotic prosthetic graft endothelialization through an isolation loop-graft model

Reduced Susceptibility of Polytetrafluoroethylene Vascular Prostheses to Colonization by Staphylococcus aureus Following In Situ Endothelialization

Nine-year patency of a vascular prosthesis used for portal vein reconstruction during pancreatoduodenectomy

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