Endotheliale Keratopathie bei Pseudoexfoliationssyndrom: Quantitative und qualitative Morphometrie mittels automatisierter Videobildanalyse

Seitz, Berthold; Müller, Elke; Langenbucher, Achim; Kus, Murat M.; Naumann, G. O. H.

doi:10.1055/s-2008-1035363

Cited by 42 publications

(30 citation statements)

References 8 publications

(13 reference statements)

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“…60 years versus those 1 60 years; (5) increased pleomorphism and polymegathism in PEX glaucoma versus PEX cataract eyes. According to the corneal endothelial features described by Seitz et al [9] , the stage of the keratopathies observed in our study may be classified as stage 2-3 in the majority of patients and is probably less advanced compared to recent clinical studies on the topic. Similar data for polymegathism in PEX endothelial cells (85%) as in our study (98.4%) and pleomorphism at 77% compared to our data of 96.8% have been observed [9] .…”

Section: Discussionsupporting

confidence: 45%

In vivo Morphometry of Corneal Endothelial Cells in Pseudoexfoliation Keratopathy with Glaucoma and Cataract

Wali¹,

Bialasiewicz²,

Rizvi

et al. 2009

Ophthalmic Res

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Background: This study was designed to define correlations between in vivo morphometric and demographic data of pseudoexfoliation (PEX) keratopathy patients from Omani Arab origin with cataract and glaucoma. Methods: In a non-randomized controlled comparative case series, 69 adult patients (43 males and 26 females) with 78 cataract and 48 glaucoma eyes with corneal PEX material were assessed by confocal biomicroscopy (Confoscan 2, Nidek) and values compared to normative US and Omani Arab population values. Descriptive statistics. Results: The mean age of glaucoma patients was 60.81 ± 8.33 years, of cataract patients 64.65 ± 6.67 years; 109/126 eyes (74%) were from patients >60 years old (14 glaucoma and 95 cataract eyes). Age-adjusted endothelial cell counts were similar to normative values in 108/126 eyes (85.7%). Polymegathism and pleomorphism were abnormal in 124/126 (98.4%) and 122/126 eyes (96.8%), respectively. The correlation of pleomorphism and polymegathism with males (R² = 0.6378, p = 0.05) was stronger than with females (R² = 0.6024, p = 0.06), and stronger for patients <60 years (R² = 0.7268, p = 0.01) than >60 years old (R² = 0.5805, p = 0.01). Cataracts: Endothelial cell counts were normal (mean 2,483 ± 511.2). Pleomorphism was 33.12 ± 11.44% and different from Omani Arab controls (p < 0.01), polymegathism 58.14 ± 16.58% (p <0.01). Glaucomas: Endothelial cell counts were normal (mean: 2,438 ± 503). Pleomorphism and polymegathism were 37.09 ± 12.43% (p < 0.01) and 59.69 ± 16.79% (p < 0.01), respectively. Pleomorphism and polymegathism were more associated with glaucomas (R² = 0.7652, p = 0.02) than with cataracts (R² = 0.6041, p = 0.06). Conclusions: Endothelial cell polymegathism and pleomorphism in PEX keratopathy with glaucoma is more frequently associated with age <60 years and male gender than with cataract.

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Section: Discussionsupporting

confidence: 45%

In vivo Morphometry of Corneal Endothelial Cells in Pseudoexfoliation Keratopathy with Glaucoma and Cataract

Wali¹,

Bialasiewicz²,

Rizvi

et al. 2009

Ophthalmic Res

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“…The loss of these cells involves an increase in size and a reduction of hexagonicity [31,32]. In our study the mean corneal endothelial cell density per mm 2 was 2239.5 ± 254.33 which was similar to previous reports and showed a statistically significant difference against the normal group 2554.2 ± 164.65 [33][34][35]. The mean percentage of hexagonal cells in PXG eyes in our study was 50.9 ± 2.47 which was in accordance to previous studies as 54.9 ± 10.9 [35], 56.4 ± 7.5 [35], 57.1 ± 7.1 [36].…”

Section: Discussionsupporting

confidence: 90%

Evaluation of Central Corneal Thickness and Corneal Endothelial Cell Parameters in Pseudoexfoliative Glaucoma

Ahmad¹,

Banday²,

Wani³

et al. 2017

J Clin Exp Ophthalmol

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“…Twelve subjects aged between 20 treated results (that is, whether they retraced the cell borders or blocked off illtraced cells). They also did not mention the number of cells counted for the analyses of ttntreated and treated data (see below).…”

Section: Methodsmentioning

confidence: 99%

“…The corneal endothelium is a monolayer, four to five micrometres thick and composed of cells l8 to 20 Endothelial cell analysis Cheung and Cln In this study, we will investigate the accuracy of the Topcon SP-1000 with the IMAGEnet system by comparing results obtained using untreated and blocked data with retraced data (that is, we make the assumption that results from retraced data represent the most accurate results).…”

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confidence: 99%

Endothelial cell analysis using the Topcon SP‐1000 non‐contact specular microscope and IMAGEnet system

Cheung

Cho

1998

Clinical and Experimental Optometry

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Introduction: A healthy corneal endothelium is essential for corneal transparency. The appearance of the corneal endothelium can be assessed quantitatively using the specular microscope combined with computer technology. Methods: Images of the corneal endothelium of 20 eyes from 12 subjects, who had normal ocular health, were captured and analysed using the Topcon SP‐1000, connected to the IMAGEnet system. Three methods of endothelial analysis (untreated, blocking and retracing) were used on each captured image. In the untreated method, the results of the analyses were automatically provided by the computer once the image was captured. For the blocking method, incorrectly traced or ill‐defined cells were blocked out by the operator manually and the endothelial variables were recalculated by the computer. For the retracing method, incorrectly traced cell borders were erased and reconstructed manually and the endothelial variables were recalculated. Results: The results obtained from the three methods of analysis were significantly different from each other (Repeated Measures Analysis of Variance, p < 0.05). Untreated results showed the highest coefficient of variation (mean ± SD: 60.1 ± 9.7 per cent) and endothelial cell density (3424.5 ± 227.7 cells/mm2) and the lowest hexagonality (38.8 ± 6.2 per cent). The results obtained using the retracing method show the lowest CV (30.2 ± 4.1 per cent) and ECD (2893.9 ± 257.2 cells/mm2) and the highest hexagonality (61.3 ± 11.4 per cent). CV. ECD and hexagonality using the blocking method were 34.0 ± 5.2 per cent, 3013.3 ± 240.8 cells/mm2 and 48.5 ± 7.4 per cent, respectively. Conclusion: The method of retracing cell borders was more time‐consuming than when untreated data was used for analysis. Nevertheless, clinicians should consider using the retracing method of analysis since the results using untreated data provided by the IMAGEnet system were significantly different from the results using retraced data, and therefore were less accurate.

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Endotheliale Keratopathie bei Pseudoexfoliationssyndrom: Quantitative und qualitative Morphometrie mittels automatisierter Videobildanalyse

Cited by 42 publications

References 8 publications

In vivo Morphometry of Corneal Endothelial Cells in Pseudoexfoliation Keratopathy with Glaucoma and Cataract

In vivo Morphometry of Corneal Endothelial Cells in Pseudoexfoliation Keratopathy with Glaucoma and Cataract

Evaluation of Central Corneal Thickness and Corneal Endothelial Cell Parameters in Pseudoexfoliative Glaucoma

Endothelial cell analysis using the Topcon SP‐1000 non‐contact specular microscope and IMAGEnet system

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