Endothelial Progenitors in the Tumor Microenvironment

Testa, Ugo; Castelli, Germana

doi:10.1007/978-3-030-44518-8_7

Cited by 17 publications

(14 citation statements)

References 188 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, the large variation in the optical properties within the same category (up to 33%) hindered further differentiation between tumor types in this cohort. This is particularly true for gliomas as they are known to have different histological properties (degree of necrosis, endothelial proliferation and genetic atypia) even within the same tumor grade . The limited capability of discriminating between tumor types based solely on tissue optical properties has also been reported elsewhere , where in vivo, frozen and fixed brain tissue samples were examined.…”

Section: Discussionmentioning

confidence: 89%

“…Brain tumors, such as gliomas, comprise of solid tumor foci with possible necrotic portions at the core and infiltrative regions at the periphery, where tumor cells often travel along the white matter tracks reaching the contralateral side . The genetic expression of each region differs, resulting in unique histopathological properties that manifest as varying degrees of nuclear abnormalities, endothelial proliferation, increased cell density, and vascularity . Consequently, the accuracy of brain tumor diagnosis following needle biopsy and standard histopathological assessment is limited leading to a misdiagnosis in 10% to 30% of the cases .…”

Section: Introductionmentioning

confidence: 89%

See 1 more Smart Citation

Comparison of optically‐derived biomarkers in healthy and brain tumor tissue under one‐ and two‐photon excitation

Sibai

Mehidine

Moawad

et al. 2019

Journal of Biophotonics

View full text Add to dashboard Cite

The surgical outcome of brain tumor resection and needle biopsy is significantly correlated to the patient's prognosis. Brain tumor surgery is limited to resecting the solid portion of the tumor as current intraoperative imaging modalities are incapable of delineating infiltrative regions. For accurate delineation, in situ tissue interrogation at the submicron scale is warranted. Additionally, multimodal detection is required to remediate the genetically and molecularly heterogeneous nature of brain tumors, notably, that of gliomas, meningioma and brain metastasis. Multimodal detection, such as spectrally‐ and temporally‐resolved fluorescence under one‐ and two‐photon excitation, enables characterizing tissue based on several endogenous optical contrasts. In order to assign the optically‐derived parameters to different tissue types, construction of an optical database obtained from biopsied tissue is warranted. This report showcases the different quantitative and semi‐quantitative optical markers that may comprise the tissue discrimination database. These include: the optical index ratio, the optical redox ratio, the relative collagen density, spectrally‐resolved fluorescence lifetime parameters, two‐photon fluorescence imaging and second harmonic generation imaging.

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 89%

Comparison of optically‐derived biomarkers in healthy and brain tumor tissue under one‐ and two‐photon excitation

Sibai

Mehidine

Moawad

et al. 2019

Journal of Biophotonics

View full text Add to dashboard Cite

show abstract

“…Specific proteins such as VEGF and FGF are secreted by cancer cells to stimulate the proliferation of capillary endothelial cells leading to the sprout and branching of them through the ECM (109). Recent evidence suggests that in tumors resistant to different anti-angiogenic drugs, in addition to angiogenesis, other processes that contribute to tumoral vascularization occur, namely vasculogenesis and vascular mimicry (110,111). Interestingly, human EVT and invasive cancer cells have similar patterns of integrins expression (Table 1), which allows the EVT to adopt a vascular phenotype capable of invading maternal spiral arterioles, a process similar to what occurs in endothelial cells when they migrate towards the tumor (5).…”

Section: Vasculogenic Capacitymentioning

confidence: 99%

Autophagy Process in Trophoblast Cells Invasion and Differentiation: Similitude and Differences With Cancer Cells

et al. 2021

View full text Add to dashboard Cite

Early human placental development begins with blastocyst implantation, then the trophoblast differentiates and originates the cells required for a proper fetal nutrition and placental implantation. Among them, extravillous trophoblast corresponds to a non-proliferating trophoblast highly invasive that allows the vascular remodeling which is essential for appropriate placental perfusion and to maintain the adequate fetal growth. This process involves different placental cell types as well as molecules that allow cell growth, cellular adhesion, tissular remodeling, and immune tolerance. Remarkably, some of the cellular processes required for proper placentation are common between placental and cancer cells to finally support tumor growth. Indeed, as in placentation trophoblasts invade and migrate, cancer cells invade and migrate to promote tumor metastasis. However, while these processes respond to a controlled program in trophoblasts, in cancer cells this regulation is lost. Interestingly, it has been shown that autophagy, a process responsible for the degradation of damaged proteins and organelles to maintain cellular homeostasis, is required for invasion of trophoblast cells and for vascular remodeling during placentation. In cancer cells, autophagy has a dual role, as it has been shown both as tumor promoter and inhibitor, depending on the stage and tumor considered. In this review, we summarized the similarities and differences between trophoblast cell invasion and cancer cell metastasis specifically evaluating the role of autophagy in both processes.

show abstract

“…Meanwhile, as results of univariate and multivariate Cox regression analyses suggested, occupation, US-LNM, US-BIRADS, clinical T stage, clinical N stage, clinical TNM stage, tumor size, pathological T stage, postoperative endocrine therapy, postoperative targeted therapy, and lymph vessel invasion were significant prognostic factors in predicting patients' improved DFS and OS. Lymph vessel invasion is thought to play an important role in tumor metastasis, and acts as the modulation of antitumor immune responses (David Nathanson et al, 2020;Testa et al, 2020;Wang et al, 2020). The tumor angiogenesis and its indicative vascular density are closely related to the prognosis of breast cancer (Huang et al, 2020;Koch et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Significance of Anisomycin-Activated Phospho-c-Jun NH2-Terminal Kinase (p-JNK) in Predicting Breast Cancer Patients’ Survival Time

Chen

Kong

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

This study aims to investigate the prognostic significance of p-JNK in breast cancer patients receiving neoadjuvant chemotherapy (NACT) and analyze the relationship between anisomycin, p-JNK. A total of 104 breast cancer patients had NACT were enrolled in this study. The western blot and immunohistochemistry assays were used to determine the protein expressions of p-JNK in human breast cancer cell lines and patients’ cancer tissues. The chi-square test and Fisher’s exact test were adopted to gauge the associations between breast cancer and clinicopathological variables by p-JNK expression, whereas the univariate and multivariate Cox proportional hazards regression models were used to analyze the prognostic value of p-JNK expression. The Kaplan-Meier plots and the log-rank test were adopted to determine patients’ disease-free survival (DFS) and overall survival (OS). Findings indicated that the p-JNK expression had prognostic significance in univariate and multivariate Cox regression survival analyses. Results of log-rank methods showed that: (1) the mean DFS and OS times in patients with high p-JNK expression were significantly longer than those in patients with low p-JNK expression (χ2 = 5.908, P = 0.015 and χ2 = 6.593, P = 0.010, respectively). p-JNK expression is a significant prognostic factor that can effectively predict the survival in breast cancer patients receiving NACT. Treatment with the JNK agonist anisomycin can induce apoptosis, lead to increased p-JNK expression and decreased p-STAT3 expression. Moreover, the p-JNK expression was inversely correlated with p-STAT3 expression.

show abstract

Endothelial Progenitors in the Tumor Microenvironment

Cited by 17 publications

References 188 publications

Comparison of optically‐derived biomarkers in healthy and brain tumor tissue under one‐ and two‐photon excitation

Comparison of optically‐derived biomarkers in healthy and brain tumor tissue under one‐ and two‐photon excitation

Autophagy Process in Trophoblast Cells Invasion and Differentiation: Similitude and Differences With Cancer Cells

The Prognostic Significance of Anisomycin-Activated Phospho-c-Jun NH2-Terminal Kinase (p-JNK) in Predicting Breast Cancer Patients’ Survival Time

Contact Info

Product

Resources

About