Endothelial progenitor cells mobilization after maximal exercise according to heart failure severity

Kourek, Christos; Karatzanos, Eleftherios; Psarra, Katherina; Georgiopoulos, Georgios; Delis, Dimitrios; Linardatou, Vasiliki; Gavrielatos, Gerasimos; Papadopoulos, Costas; Nanas, Serafim; Dimopoulos, Stavros

doi:10.4330/wjc.v12.i11.526

Cited by 10 publications

(28 citation statements)

References 34 publications

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“…Fifteen clinical trials examined the acute effects to exercise (Adams et al 2004 ; Shaffer et al 2006 ; Van Craenenbroeck et al 2009 ; Van Craenenbroeck et al 2010a ; Sandri et al 2011 ; Van Craenenbroeck et al 2011 ; Rummens et al 2012 ; Scalone et al 2013 ; Kazmierski et al 2015 ; Rocha et al 2015 ; West et al 2015 ; Lutz et al 2016 ; Waclawovsky et al 2016 ; Gevaert et al 2019 ; Kourek et al 2020b ) (Table 1 ). Thirteen trials included independent groups before and after (Adams et al 2004 ; Shaffer et al 2006 ; Van Craenenbroeck et al 2009 ; Van Craenenbroeck et al 2010a ; Van Craenenbroeck et al 2011 ; Rummens et al 2012 ; Scalone et al 2013 ; Kazmierski et al 2015 ; Rocha et al 2015 ; West et al 2015 ; Lutz et al 2016 ; Gevaert et al 2019 ; Kourek et al 2020b ), one was a single arm trial (Sandri et al 2011 ) and another one a randomised cross over trial (Waclawovsky et al 2016 ). Across the 15 included trials (649 participants), 13 reported percentages of male and female distribution (Van Craenenbroeck et al 2009 ; Van Craenenbroeck et al 2010a ; Sandri et al 2011 ; Van Craenenbroeck et al 2011 ; Rummens et al 2012 ; Scalone et al 2013 ; Kazmierski et al 2015 ; Rocha et al 2015 ; West et al 2015 ; Lutz et al 2016 ; Waclawovsky et al 2016 ; Gevaert et al 2019 ; Kourek et al 2020b ).…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen trials included independent groups before and after (Adams et al 2004 ; Shaffer et al 2006 ; Van Craenenbroeck et al 2009 ; Van Craenenbroeck et al 2010a ; Van Craenenbroeck et al 2011 ; Rummens et al 2012 ; Scalone et al 2013 ; Kazmierski et al 2015 ; Rocha et al 2015 ; West et al 2015 ; Lutz et al 2016 ; Gevaert et al 2019 ; Kourek et al 2020b ), one was a single arm trial (Sandri et al 2011 ) and another one a randomised cross over trial (Waclawovsky et al 2016 ). Across the 15 included trials (649 participants), 13 reported percentages of male and female distribution (Van Craenenbroeck et al 2009 ; Van Craenenbroeck et al 2010a ; Sandri et al 2011 ; Van Craenenbroeck et al 2011 ; Rummens et al 2012 ; Scalone et al 2013 ; Kazmierski et al 2015 ; Rocha et al 2015 ; West et al 2015 ; Lutz et al 2016 ; Waclawovsky et al 2016 ; Gevaert et al 2019 ; Kourek et al 2020b ). Across these 13 trials (573 participants), 435 were males (75.9%) and 138 were females (24.1%).…”

Section: Resultsmentioning

confidence: 99%

“…Lastly, as a secondary outcome four trials measured the number and/ or function of cultured myeloid angiogenic cells (MACs) defined as double positive for acetylated Low-Density Lipoprotein labelled with 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate and lectin (Di-acLDL + / lectin + cells) (Adams et al 2004;. Ten out of the 15 trials (Table 2) predominantly included two blood collection time points for circulating EPCs with the post-exercise time point varying between immediately post-exercise and 24 h post-exercise (Shaffer et al 2006;Van Craenenbroeck et al 2009;Van Craenenbroeck et al 2010a;Rummens et al 2012;Scalone et al 2013;Rocha et al 2015;Lutz et al 2016;Waclawovsky et al 2016;Gevaert et al 2019;Kourek et al 2020b). The most common time point adopted in the majority of trials was 10 min post-exercise.…”

Section: Acute Clinical Trial Characteristics and Intervention Detailsmentioning

confidence: 99%

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The impact of different forms of exercise on circulating endothelial progenitor cells in cardiovascular and metabolic disease

et al. 2022

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Circulating endothelial progenitor cells (EPCs) contribute to vascular repair and their monitoring could have prognostic clinical value. Exercise is often prescribed for the management of cardiometabolic diseases, however, it is not fully understood how it regulates EPCs. Objectives: to systematically examine the acute and chronic effects of different exercise modalities on circulating EPCs in patients with cardiovascular and metabolic disease. Methods: Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed. Results: six electronic databases and reference lists of eligible studies were searched to April 2021. Thirty-six trials met the inclusion criteria including 1731 participants. Acute trials: in chronic heart failure (CHF), EPC mobilisation was acutely increased after high intensity interval or moderate intensity continuous exercise training, while findings were inconclusive after a cardiopulmonary cycling exercise test. Maximal exercise tests acutely increased EPCs in ischaemic or revascularized coronary artery disease (CAD) patients. In peripheral arterial disease (PAD), EPC levels increased up to 24 h post-exercise. In patients with compromised metabolic health, EPC mobilisation was blunted after a single exercise session. Chronic trials: in CHF and acute coronary syndrome, moderate intensity continuous protocols, with or without resistance exercise or calisthenics, increased EPCs irrespective of EPC identification phenotype. Findings were equivocal in CAD regardless of exercise mode, while in severe PAD disease EPCs increased. High intensity interval training increased EPCs in hypertensive metabolic syndrome and heart failure reduced ejection fraction. Conclusion: the clinical condition and exercise modality influence the degree of EPC mobilisation and magnitude of EPC increases in the long term. Graphical abstract

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Acute Clinical Trial Characteristics and Intervention Detailsmentioning

confidence: 99%

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The impact of different forms of exercise on circulating endothelial progenitor cells in cardiovascular and metabolic disease

et al. 2022

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“…No espaço de tempo delimitado para a realização deste estudo (2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018)(2019)(2020) No estudo de Kourek et al (2020), buscaram avaliar quantificar e comparar a mobilização aguda das CPE após exercício máximo em pacientes com insuficiência cardíaca crônica (ICC). Para isso, selecionaram 49 pacientes consecutivos com ICC estável e um fração de ejeção reduzida ou média (EF) que foram submetidos a uma única sessão de teste de exercício cardiopulmonar máximo (CPET).…”

Section: Resultsunclassified

Influência da atividade física e exercício nas células progenitoras endoteliais em pacientes com insuficiência cardíaca: revisão integrativa da literatura

Espir

Pardini

Costa

et al. 2021

RSD

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A Insuficiência Cardíaca é a deficiência do sistema cardiovascular de suprir as necessidades metabólicas dos tecidos corpóreos. Tal condição é agravada pela disfunção endotelial, em que há desequilíbrio na produção endotelial de mediadores que regulam a homeostase vascular. Desta Forma o objetivo dest estudo foi revisar na literatura as evidências acerca da influência da atividade física na função endotelial e na indução de progenitores endoteliais em indivíduos com IC. Revisão Integrativa da literatura na base de dados PubMed das produções dos últimos 10 anos. Os descritores utilizados foram: “Insuficiência Cardíaca”, “Exercícios”, “Atividade Física” e “Células Progenitoras Endoteliais”, os quais foram conjugados para delimitação da busca. Foram selecionados 9 artigos ao final das etapas de busca. Sendo o ano de 2010 o mais prevalente com 33,3% das publicações, seguido pelo ano de 2013 com 22,2% das publicações. Em relação ao país de origem dos estudos, 66,6% foram conduzidos na Alemanha, Bélgica e Taiwan (22,2% em cada um dos países citados), seguidos pelos estudos realizados na Itália, Grécia e Reino Unido, cada país com 11,1%. Foram encontradas evidências que mostram a efetividade do exercício físico na reparação endotelial e na produção de mediadores vasculares, com ênfase nas células progenitoras endoteliais (CPE). Em pacientes com insuficiência cardíaca de graus variados, constata-se um aumento da neovascularização muscular e uma melhora da função cardíaca após a realização de atividades físicas, induzidas pelas CPE. Desta forma, em conjunto com as terapias medicamentosas, a adoção de mudanças no estilo de vida e a realização de exercícios físicos em indivíduos com insuficiência cardíaca e com disfunções endoteliais são recomendados. Evidências também mostram que há um aumento na mobilização de outros mediadores que contribuem para tais melhorias, como CD34+ e VEGF. Com relação à melhora da função endotelial e à indução de progenitores endoteliais, em média, os estudos analisados demonstraram resultados satisfatórios que esclarecem a importância do exercício físico na qualidade de vida e sobrevida dos portadores de IC.

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“…We extended previous findings by showing that a single bout of maximal exercise, as well as many bouts organized as an exercise training program, stimulates the mobilization of EPCs and CECs from the bone marrow in patients with chronic HF[ 8 , 10 ]. This beneficial effect of exercise seems to be similar in chronic HF patients of different severity[ 9 ].…”

Section: The Effect Of Exercise Training In the Cardiomyocytes Vascular Endothelial Function And Skeletal Musclesmentioning

confidence: 99%

Exercise training in heart transplantation

Kourek¹,

Karatzanos²,

Nanas³

et al. 2021

WJT

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Heart transplantation remains the gold standard in the treatment of end-stage heart failure (HF). Heart transplantation patients present lower exercise capacity due to cardiovascular and musculoskeletal alterations leading thus to poor quality of life and reduction in the ability of daily self-service. Impaired vascular function and diastolic dysfunction cause lower cardiac output while decreased skeletal muscle oxidative fibers, enzymes and capillarity cause arteriovenous oxygen difference, leading thus to decreased peak oxygen uptake in heart transplant recipients. Exercise training improves exercise capacity, cardiac and vascular endothelial function in heart transplant recipients. Pre-rehabilitation regular aerobic or combined exercise is beneficial for patients with end-stage HF awaiting heart transplantation in order to maintain a higher fitness level and reduce complications afterwards like intensive care unit acquired weakness or cardiac cachexia. All hospitalized patients after heart transplantation should be referred to early mobilization of skeletal muscles through kinesiotherapy of the upper and lower limbs and respiratory physiotherapy in order to prevent infections of the respiratory system prior to hospital discharge. Moreover, all heart transplant recipients after hospital discharge who have not already participated in an early cardiac rehabilitation program should be referred to a rehabilitation center by their health care provider. Although high intensity interval training seems to have more benefits than moderate intensity continuous training, especially in stable transplant patients, individualized training based on the abilities and needs of each patient still remains the most appropriate approach. Cardiac rehabilitation appears to be safe in heart transplant patients. However, long-term follow-up data is incomplete and, therefore, further high quality and adequately-powered studies are needed to demonstrate the long-term benefits of exercise training in this population.

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Endothelial progenitor cells mobilization after maximal exercise according to heart failure severity

Cited by 10 publications

References 34 publications

The impact of different forms of exercise on circulating endothelial progenitor cells in cardiovascular and metabolic disease

The impact of different forms of exercise on circulating endothelial progenitor cells in cardiovascular and metabolic disease

Influência da atividade física e exercício nas células progenitoras endoteliais em pacientes com insuficiência cardíaca: revisão integrativa da literatura

Exercise training in heart transplantation

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