Endothelial Progenitor Cells May Be Related to Major Amputation after Angioplasty in Patients with Critical Limb Ischemia

Santillán-Cortez, Daniel; Vera-Gómez, Eduardo; Hernández-Patricio, Alejandro; Ruíz-Hernández, Atzin Suá; Gutiérrez-Buendía, Juan Ariel; Vega-Moreno, Karen De la; Rizo-García, Yasser Alberto; Lomán-Zúñiga, Oscar Antonio; Escotto-Sánchez, Ignacio; Rodríguez-Trejo, Juan Miguel; Téllez-González, Mario Antonio; Toledo-Lozano, Christian Gabriel; Ortega-Rosas, Tania; García, Silvia; Mondragón-Terán, Paul; Suárez‐Cuenca, Juan Antonio

doi:10.3390/cells12040584

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…The study by Santillán-Cortez et al investigates the correlation between endothelial progenitor cells (EPCs) and major amputation after angioplasty in critical limb ischemia patients [26]. Considering this cellular aspect enriches our understanding of the disease process.…”

Section: Discussionmentioning

confidence: 99%

Histological Changes in the Popliteal Artery Wall in Patients with Critical Limb Ischemia

Andercou,

Andrei,

Gheban

et al. 2024

Diagnostics

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Introduction: This prospective study aims to illustrate the histopathological arterial changes in the popliteal artery in peripheral arterial disease of the lower limbs. Material and method: A total of 60 popliteal artery segments taken from patients who had undergone lower limb amputation were examined between April and June 2023. The degree of arterial stenosis, medial calcinosis, and the vasa vasorum changes in the arterial adventitia were quantified. The presence of risk factors for atherosclerosis was also observed. Results: Atherosclerotic plaque was found in all of the examined segments. Medial calcinosis was observed in 40 (66.6%) of the arterial segments. A positive association between the degree of arterial stenosis and the vasa vasorum changes in the arterial adventitia was also found (p = 0.025). The level of blood sugar and cholesterol were predictive factors for the severity of atherosclerosis. Conclusions: Atherosclerosis and medial calcinosis are significant in patients who underwent lower limb amputation. Medial calcinosis causes damage to the arterial wall and leads to a reduction in responsiveness to dilator stimuli.

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Section: Discussionmentioning

confidence: 99%

Histological Changes in the Popliteal Artery Wall in Patients with Critical Limb Ischemia

Andercou,

Andrei,

Gheban

et al. 2024

Diagnostics

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“… 35 , 36 , 37 , 38 An additional explanation for the increased incidence of HF after amputation is an increased prevalence of traditional cardiovascular disease risk factors, including increased insulin resistance, 24 , 25 arterial stiffness, 35 , 39 and endothelial dysfunction. 40 …”

Section: Discussionmentioning

confidence: 99%

Risk of Heart Disease in Patients With Amputation: A Nationwide Cohort Study in South Korea

Choi,

Yoo,

Kim

et al. 2024

JAHA

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Background Amputation confers disabilities upon patients and is linked to substantial morbidity and death attributed to heart disease. While some studies have focused on traumatic amputees in veterans, few studies have focused on traumatic amputees within the general population. Therefore, the present study aimed to assess the risk of heart disease in patients with traumatic amputation with disability within the general population using a large‐scale nationwide population‐based cohort. Methods and Results We used data from the Korean National Health Insurance System. A total of 22 950 participants with amputation were selected with 1:3 age, sex‐matched controls between 2010 and 2018. We used Cox proportional hazard models to calculate the risk of myocardial infarction, heart failure, and atrial fibrillation among amputees. Participants with amputation had a higher risk of myocardial infarction (adjusted hazard ratio [aHR], 1.30 [95% CI, 1.14–1.47]), heart failure (aHR, 1.27 [95% CI, 1.17–1.38]), and atrial fibrillation (aHR, 1.17 [95% CI, 1.03–1.33]). The risks of myocardial infarction and heart failure were further increased by the presence of disability (aHR, 1.43 [95% CI, 1.04–1.95]; and aHR, 1.38 [95% CI, 1.13–1.67], respectively). Conclusions We demonstrate an increased risk of myocardial infarction, heart failure, and atrial fibrillation among individuals with amputation, and the risk further increased in those with disabilities. Clinicians should pay attention to the increased risk for heart disease in patients with amputation.

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“…In various research, improved parameters of EPC biology (e.g., increased EPC blood count quantified by flow cytometry or improved EPC function in cultures) could be correlated with improved flow-mediated dilation, brachial ankle index, or intima media thickness [18][19][20]. Furthermore, EPC biology was found to correlate with clinical outcomes like limb amputation, stroke, myocardial infarction, or death [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Modern Anti-Diabetic Treatment on Endothelial Progenitor Cells

Altabas,

Marinković Radošević,

Špoljarec

et al. 2023

Biomedicines

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Diabetes is one of the leading chronic diseases globally with a significant impact on mortality. This condition is associated with chronic microvascular and macrovascular complications caused by vascular damage. Recently, endothelial progenitor cells (EPCs) raised interest due to their regenerative properties. EPCs are mononuclear cells that are derived from different tissues. Circulating EPCs contribute to regenerating the vessel’s intima and restoring vascular function. The ability of EPCs to repair vascular damage depends on their number and functionality. Diabetic patients have a decreased circulating EPC count and impaired EPC function. This may at least partially explain the increased risk of diabetic complications, including the increased cardiovascular risk in these patients. Recent studies have confirmed that many currently available drugs with proven cardiovascular benefits have beneficial effects on EPC count and function. Among these drugs are also medications used to treat different types of diabetes. This manuscript aims to critically review currently available evidence about the ways anti-diabetic treatment affects EPC biology and to provide a broader context considering cardiovascular complications. The therapies that will be discussed include lifestyle adjustments, metformin, sulphonylureas, gut glucosidase inhibitors, thiazolidinediones, dipeptidyl peptidase 4 inhibitors, glucagon-like peptide 1 receptor analogs, sodium-glucose transporter 2 inhibitors, and insulin.

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Endothelial Progenitor Cells May Be Related to Major Amputation after Angioplasty in Patients with Critical Limb Ischemia

Cited by 4 publications

References 38 publications

Histological Changes in the Popliteal Artery Wall in Patients with Critical Limb Ischemia

Histological Changes in the Popliteal Artery Wall in Patients with Critical Limb Ischemia

Risk of Heart Disease in Patients With Amputation: A Nationwide Cohort Study in South Korea

The Impact of Modern Anti-Diabetic Treatment on Endothelial Progenitor Cells

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