Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease

Aragona, Caterina Oriana; Imbalzano, Egidio; Mamone, F.; Cairo, V.; Gullo, Alberto Lo; D’Ascola, Angela; Sardo, M.A.; Scuruchi, Michele; Basile, Giorgio; Saitta, Antonino; Mandraffino, Giuseppe

doi:10.1155/2016/8043792

Cited by 64 publications

(45 citation statements)

References 114 publications

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“…It is becoming a global health burden and is still the number one cause of morbidity and mortality worldwide [19, 20]. Many risk factors could individually or combinedly trigger CVD, such as family history, ethnicity, age, tobacco exposure, high blood pressure, high cholesterol, obesity, physical inactivity, diabetes, unhealthy diets, and harmful use of alcohol.…”

Section: Introductionmentioning

confidence: 99%

Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases

Wang

Liu

et al. 2017

CPD

195

125

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Salvia miltiorrhiza Bunge, also known as Danshen in Chinese, has been widely used to treat cardiovascular diseases (CVD) in China and other Asia countries. Here, we summarize literatures of the historical traditional Chinese medicine (TCM) interpretation of the action of Salvia miltiorrhiza, its use in current clinical trials, its main phytochemical constituents and its pharmacological findings by consulting Pubmed, China Knowledge Resource Integrated, China Science and Technology Journal, and the Web of Science Databases. Since 2000, 39 clinical trials have been identified that used S. miltiorrhiza in TCM prescriptions alone or with other herbs for the treatment of patients with CVD. More than 200 individual compounds have been isolated and characterized from S. miltiorrhiza, which exhibited various pharmacological activities targeting different pathways for the treatment of CVD in various animal and cell models. The isolated compounds may provide new perspectives in alternative treatment regimes and reveal novel chemical scaffolds for the development of anti-CVD drugs. Meanwhile, there are also some rising concerns of the potential side effects and drug-drug interactions of this plant. The insights gained from this study will help us to better understanding of the actions of this herb for management of cardiovascular disorders. As an herb of red root, S. miltiorrhiza will act as a potential red light to prevent the development of CVD.

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Section: Introductionmentioning

confidence: 99%

Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases

Wang

Liu

et al. 2017

CPD

195

125

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“…The idea of liquid biopsy is not restricted to oncology but applicable to prenatal diagnostics [1], cardiovascular diseases [2] or atherosclerosis [3]. Liquid biopsy of blood samples in oncology includes intact cells, cell-free nucleic acids or other components, e.g.…”

Section: Introductionmentioning

confidence: 99%

Liquid Biopsy: Current Status and Future Perspectives

Mader¹,

Pantel²

2017

Oncol Res Treat

201

145

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Cancer patients usually receive therapies according to their primary tumor's molecular traits. These characteristics may change during the molecular evolution of distant metastases as the leading cause of cancer deaths. Primary tumor tissue, if accessible at all, does not always provide enough information to stratify individual patients to the most promising therapy. Re-analysis of metastatic lesions by needle biopsy is possible but invasive, and limited by the known intra-patient heterogeneity of individual lesions. These hurdles might be overcome by analyzing tumor cells or tumor cell products in blood samples (liquid biopsy), which in principle might reflect all subclones present at that specific time point and allow sequential monitoring of disease evolution. Liquid biopsies inform on circulating tumor cells as well as tumor-derived cell-free nucleic acids, exosomes and platelets. Here, we introduce the different approaches of blood-based liquid biopsies and discuss the clinical applications in oncology.

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“…Encouraged by the recent findings of Aragona et al (2016) who reported that there is a close connection between the regeneration ability and the capabilities of endothelial progenitor cells, we hypothesise that many health issues of high producing Holstein Friesian cows are an effect of altered angiogenesis or vasculogenesis. Consequently the objective of this pilot study was to investigate blood vessel development in the corpus luteum of HPC (specifically high milk-producing Holstein Friesian dairy cows) and to compare this with that of beef and dual purpose cattle (non high-producing breeds [NHPC]).…”

mentioning

confidence: 95%

Corpus luteal angiogenesis in a high milk production dairy breed differs from that of cattle with lower milk production levels

Kaessmeyer¹,

Huenigen²,

Masri³

et al. 2016

Vet. Med. - Czech

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Globally, high producing, young dairy cows often have health and fertility problems such as ovarian, uterine and placental dysfunction, mastitis and impaired wound healing. These health issues can result in a shortened average lifespan of fewer than three lactations. We hypothesise that many of these health issues may be an effect of altered angiogenesis. Hence, the aim of this pilot study was to investigate the status of vascularisation in the corpus luteum of a high milk-producing cattle breed (Holstein Friesian) compared with that of low milk producing beef cattle (Limousin) and of dual purpose cattle (Fleckvieh, Rotbunt). The corpus luteum was chosen because as a transient endocrine gland it is one of the few tissues with physiological angiogenesis in the adult. Blood vessels were labelled in paraffin sections of corpora lutea with the lectin Bandeiraea simplicifolia agglutinin I and the following angiogenesis parameters were analysed morphometrically using image analysis: (a) number of blood capillaries per mm 2 , (b) intercapillary distance, (c) percentage area occupied by blood vessels and (d) area of blood vessel lumina (μm 2 ). This analysis revealed that the extent of corpus luteal vascularisation is greater in high milk-producing cattle than in beef and dual purpose cattle as shown by a significantly higher number of blood capillaries per mm², significantly shorter intercapillary distances and a higher percentage of the corpus luteum area covered by blood vessels (non-significant). Only the average value of the luminal area of the luteal blood capillaries in the high milk-producing cattle is smaller than that measured in the low producing cattle.

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Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease

Cited by 64 publications

References 114 publications

Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases

Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases

Liquid Biopsy: Current Status and Future Perspectives

Corpus luteal angiogenesis in a high milk production dairy breed differs from that of cattle with lower milk production levels

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