Endothelial progenitor cells as markers of severity in hypertrophic cardiomyopathy

Kalyva, Athanasia; Marketou, Maria; Parthenakis, Fragiskos I.; Pontikoglou, Charalampos; Kontaraki, Joanna; Maragkoudakis, Spyros; Petousis, Stylianos; Chlouverakis, Gregory; Papadaki, Helen Α.; Vardas, Panos

doi:10.1002/ejhf.436

Cited by 6 publications

(8 citation statements)

References 35 publications

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“…Described mechanisms may also explain the positive relationship between CEPCs and ECG parameters of LVH: LVM as well as LVMI was found in RH patients and confirmed by other authors (Oliveras et al, 2008; Kalyva et al, 2016). This correlation may indicate mobilization of CEPCs from bone morrow rising adequately to organ damage, despite the fact that CEPCs level in the circulation do not elevate proportionally, due to failure mechanisms described above.…”

Section: Discussionsupporting

confidence: 81%

The Potential Role of Circulating Endothelial Cells and Endothelial Progenitor Cells in the Prediction of Left Ventricular Hypertrophy in Hypertensive Patients

et al. 2019

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Background The main aim of present study is to evaluate the potential role of circulating endothelial cells (CECs) and endothelial progenitor cells (CEPCs) – representing specific markers of endothelial damage, in the prediction of left ventricular hypertrophy (LVH) in hypertensive patients categorized into two groups; mild (MH) and resistant hypertension (RH). Materials and Methods Thirty patients with MH and 28 subjects with RH were involved in the study. In both groups, patients were divided into an LVH and non-LVH group. The control group included 33 age and sex-matched normotensive volunteers. Physical examination, laboratory tests and echocardiography were conducted. Results In both the MH and RH group, patients with as well as without LVH demonstrated a higher number of CECs and a lower ratio of CEPCs/CECs as compared to the healthy control. Multiple linear regression analysis showed a positive association of CEPCs with left ventricular mass (LVM) and left ventricular mass index (LVMI), independently of other confounders. Conclusion Our results suggest that endothelial injury observed as an elevated CECs number and its impaired regeneration, reflected by a lowered CEPCs/CECs ratio, precede LVH occurrence and may play a significant role in LVH development regardless of the clinical severity of hypertension. Moreover, independent correlation of CEPCs with echocardiographic (ECG) incidences of LVH suggests their potential use as a screening biomarker to stratify the risk of LVH development.

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Section: Discussionsupporting

confidence: 81%

The Potential Role of Circulating Endothelial Cells and Endothelial Progenitor Cells in the Prediction of Left Ventricular Hypertrophy in Hypertensive Patients

et al. 2019

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“…90 In human patients, HCM was found to be associated with an increase in CD45À/CD34þ/ VEGFR2þ and CD45À/CD34þ/CD133þ circulating endothelial progenitor cells (EPC) which was hypothesized to play a role in angiogenic processes in the myocardium. 41 While we found interstitial cells with strong CD34 transcription and cells with a VEGFR2 mRNA signal, there were none transcribing CD133. Since CD133 is rapidly lost with differentiation of EPCs and immature endothelial cells and is generally expressed in stem cells, 34,78 the absence of cells transcribing CD133 could indicate that the progenitor cells involved in the remodeling processes in fHCM are generally in a more advanced stage of differentiation.…”

Section: Discussionmentioning

confidence: 53%

“…The human literature also suggests that circulating stem cells play a role in the myocardial repair processes that follow ischemic insults such as coronary obstruction, and that subpopulations of macrophages, both resident and blood-derived, might play regulatory or pro-inflammatory roles in the course of an infarction process. 8 , 41 This suggests that blood-derived stem cells could also be relevant to the pathogenesis of fHCM.…”

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confidence: 99%

Feline hypertrophic cardiomyopathy: reduced microvascular density and involvement of CD34+ interstitial cells

et al. 2021

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The sequence of pathological events in feline hypertrophic cardiomyopathy (fHCM) is still largely unknown, although we know that fHCM is characterized by interstitial remodeling in a macrophage-driven pro-inflammatory environment and that myocardial ischemia might contribute to its progression. This study aimed to gain further insights into the structural changes associated with interstitial remodeling in fHCM with special focus on the myocardial microvasculature and the phenotype of the interstitial cells. Twenty-eight hearts (16 hearts with fHCM and 12 without cardiac disease) were evaluated in the current study, with immunohistochemistry, RNA-in situ hybridization, and transmission electron microscopy. Morphometrical evaluations revealed a statistically significant lower microvascular density in fHCM. This was associated with structural alterations in capillaries that go along with a widening of the interstitium due to the accumulation of edema fluid, collagen fibers, and mononuclear cells that also proliferated locally. The interstitial cells were mainly of fibroblastic or vascular phenotype, with a substantial contribution of predominantly resident macrophages. A large proportion expressed CD34 mRNA, which suggests a progenitor cell potential. Our results indicate that microvascular alterations are key events in the pathogenesis of fHCM and that myocardial interstitial cell populations with CD34+ phenotype play a role in the pathogenesis of the disease.

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“…Endothelial progenitor cells (EPCs) play an important role in vasculogenesis and endothelial homeostasis 7 . Different mobilization of EPCs has been described in patients with dilated, hypertrophic and peripartum cardiomyopathy compared with healthy individuals 8‐11 . No published data exists on endothelial function biomarkers in post TCM patients.…”

Section: Introductionmentioning

confidence: 99%

“…7 Different mobilization of EPCs has been described in patients with dilated, hypertrophic and peripartum cardiomyopathy compared with healthy individuals. [8][9][10][11] No published data exists on endothelial function biomarkers in post TCM patients.…”

Section: Introductionmentioning

confidence: 99%

Residual alterations of cardiac and endothelial function in patients who recovered from Takotsubo cardiomyopathy

Zilberman

Zalik

Fugenfirov

et al. 2021

Clinical Cardiology

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Introduction Takotsubo cardiomyopathy (TCM) is characterized by transient left ventricle dysfunction. Hypothesis A residual cardiac and endothelial dysfunction is present in patients who recovered from TCM. Methods In this single‐center prospective study, patients with prior TCM were included and followed for 6.4 ± 1.6 years. All underwent comprehensive cardiac function assessment, including tissue Doppler imaging (TDI) and 2‐dimensional strain (2DS) echocardiography at their first visit. The number of circulating endothelial progenitor cells and levels of proangiogenic vascular endothelial growth factor (VEGF) and its receptor (VEGF‐R) were measured. All measurements were compared with healthy controls. Results Forty‐two women (age 58. ±8.6 years, LVEF 58.1 ± 6.1%) comprised the TCM group. Patients post‐TCM had significantly lower early velocities E′ (6 (5.0–8.0) vs. 9 (7.0–11.0) cm/s, p = .001) by TDI and higher E/E′ ratio (p = .002), lower LV global average longitudinal strain (LGS) (−18.9 ± 3.5% vs. −21.7 ± 2.3%, p = .002) and RV LGS (−20.1 ± 3.9% vs. −23.4 ± 2.8%, p = .003) were evident. There was a trend toward a higher VEGF‐R (p = .09) along with decreased VEGF/VEGF‐R ratio representing inadequate VEGF production. In‐hospital mortality was not reported and only two non‐cardiac deaths occurred at long‐term follow‐up. Conclusions Altered TDI and 2DS indices suggest residual biventricular myocardial injury in post‐TCM patients with the apparent LV function recovery. Inappropriate production of VEGF and VEGF‐R were observed, suggesting a possible underlying endothelial dysfunction in these patients.

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Endothelial progenitor cells as markers of severity in hypertrophic cardiomyopathy

Cited by 6 publications

References 35 publications

The Potential Role of Circulating Endothelial Cells and Endothelial Progenitor Cells in the Prediction of Left Ventricular Hypertrophy in Hypertensive Patients

The Potential Role of Circulating Endothelial Cells and Endothelial Progenitor Cells in the Prediction of Left Ventricular Hypertrophy in Hypertensive Patients

Feline hypertrophic cardiomyopathy: reduced microvascular density and involvement of CD34+ interstitial cells

Residual alterations of cardiac and endothelial function in patients who recovered from Takotsubo cardiomyopathy

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